Clement K. Gwede, PhD, MPH, RN

Despite major advances in cancer screening, early detection and care, there are marked and persistent disparities in outcomes for African-Americans/Blacks and other medically underserved populations.  As such, over the past few years Dr. Gwede's research has spanned the continuum of cancer care with the following broad goals: reducing cancer disparities through community-based interventions to promote informed decision making and early detection for prostate and colorectal cancer; increasing participation of racial-ethnic minorities in clinical research; and symptom management interventions to improve quality of life during and after cancer treatment. Supported by grants from the ACS and NCI, current research by Dr. Gwede and colleagues uses community-based participatory research methods and community-academic partnerships to develop and implement culturally targeted, linguistically and literacy relevant interventions to increase colorectal cancer screening among diverse medically underserved populations in community health clinics and other community settings.  In the area of symptom management and quality of life, Dr. Gwede seeks to prevent or ameliorate the burden of debilitating chemoradiation-induced symptoms in national or multinational cooperative clinical trials.

• Gwede CK, Ashley AA, McGinnis K, Montiel-Ishino FA, Standifer M, Baldwin J, Williams C, Sneed KB, Wathington D, Dash-Pitts L, Green BL. Designing a community-based lay health advisor training curriculum to address cancer health disparities. Health Promot Pract. 2013 May;14(3):415-424. Pubmedid: 22982709. Pmcid: PMC3619005.
• Koskan A, Arevalo M, Gwede CK, Quinn GP, Noel-Thomas SA, Luque JS, Wells KJ, Meade CD. Ethics of clear health communication: applying the CLEAN Look approach to communicate biobanking information for cancer research. J Health Care Poor Underserved. 2012 Nov;23(4 Suppl):58-66. Pubmedid: 23124500.
• Gwede CK, Castro E, Brandon TH, McIntyre J, Meade CD, Munoz-Antonia T, Simmons VN, Vadaparampil ST, Jimenez J, Quinn GP. Developing Strategies for Reducing Cancer Disparities via Cross-Institutional Collaboration: Outreach Efforts for the Partnership Between the Ponce School of Medicine and the Moffitt Cancer Center. Health Promot Pract. 2012 Nov;13(6):807-815. Pubmedid: 22167362.
• Siddiqui F, Gwede CK. Head and neck cancer in the elderly population. Semin Radiat Oncol. 2012 Oct;22(4):321-333. Pubmedid: 22985815.
• Rivers BM, August EM, Quinn GP, Gwede CK, Pow-Sang JM, Green BL, Jacobsen PB. Understanding the Psychosocial Issues of African American Couples Surviving Prostate Cancer. J Cancer Educ. 2012 Apr. Pubmedid: 22544536.
• Luque JS, Quinn GP, Montel-Ishino FA, Arevalo M, Bynum SA, Noel-Thomas S, Wells KJ, Gwede CK, Meade CD. Formative research on perceptions of biobanking: what community members think. J Cancer Educ. 2012 Mar;27(1):91-99. Pubmedid: 21927867.
• Quinn GP, Vadaparampil ST, Gwede CK, Reinecke JD, Mason TM, Silva C. Developing a referral system for fertility preservation among patients with newly diagnosed cancer. J Natl Compr Canc Netw. 2011 Nov;9(11):1219-1225. Pubmedid: 22056654.
• Meade CD, Menard JM, Luque JS, Martinez-Tyson D, Gwede CK. Creating community-academic partnerships for cancer disparities research and health promotion. Health Promot Pract. 2011 Aug;12(3):456-462. Pubmedid: 19822724. Pmcid: PMC3653573.
• Gwede CK, Jean-Francois E, Quinn GP, Wilson S, Tarver WL, Thomas KB, Vadaparampil ST, Meade CD. Perceptions of colorectal cancer among three ethnic subgroups of US blacks: a qualitative study. J Natl Med Assoc. 2011 Aug;103(8):669-680. Pubmedid: 22046844.
• Quinn GP, Jimenez J, Meade CD, Muñoz-Antonia T, Gwede CK, Castro E, Vadaparampil ST, Simmons VN, McIntyre J, Crocker TT, Brandon TH. Enhancing Oncology Health Care Provider's Sensitivity to Cultural Communication to Reduce Cancer Disparities: A Pilot Study. J Cancer Educ. 2011 Jun;26(2):322-325. Pubmedid: 21479572.
• Simmons VN, Jiménez JC, Castro E, Litvin EB, Gwede CK, Vadaparampil ST, Mclntyre J, Meade CD, Brandon TH, Quinn GP. Initial efforts in community engagement with health care providers: perceptions of barriers to care for cancer patients in Puerto Rico. P R Health Sci J. 2011 Mar;30(1):28-34. Pubmedid: 21449495.
• Luque JS, Rivers BM, Gwede CK, Kambon M, Green BL, Meade CD. Barbershop communications on prostate cancer screening using barber health advisers. Am J Mens Health. 2011 Mar;5(2):129-139. Pubmedid: 20413392.
• Rivers BM, August EM, Gwede CK, Hart A, Donovan KA, Pow-Sang JM, Quinn GP. Psychosocial issues related to sexual functioning among African-American prostate cancer survivors and their spouses. Psychooncology. 2011 Jan;20(1):106-110. Pubmedid: 20187071.
• Mhaskar AR, Quinn G, Vadaparampil S, Djulbegovic B, Gwede CK, Kumar A. Timing of first-line cancer treatments - early versus late - a systematic review of phase III randomized trials. Cancer Treat Rev. 2010 Dec;36(8):621-628. Pubmedid: 20444550.
• Gwede CK, Menard JM, Martinez-Tyson D, Lee JH, Vadaparampil ST, Padhya TA, Meade CD. Strategies for assessing community challenges and strengths for cancer disparities participatory research and outreach. Health Promot Pract. 2010 Nov;11(6):876-887. Pubmedid: 19515858. Pmcid: PMC2888920.
• Gwede CK, William CM, Thomas KB, Tarver WL, Quinn GP, Vadaparampil ST, Kim J, Lee JH, Meade CD. Exploring disparities and variability in perceptions and self-reported colorectal cancer screening among three ethnic subgroups of U. S. Blacks. Oncol Nurs Forum. 2010 Sep;37(5):581-591. Pubmedid: 20797950. Pmcid: PMC2946332.
• Ulrich CM, James JL, Walker EM, Stine SH, Gore E, Prestidge B, Michalski J, Gwede CK, Chamberlain R, Bruner DW. RTOG physician and research associate attitudes, beliefs and practices regarding clinical trials: implications for improving patient recruitment. Contemp Clin Trials. 2010 May;31(3):221-228. Pubmedid: 20215046.
• Zachariah B, Gwede CK, James J, Ajani J, Chin LJ, Donath D, Rosenthal SA, Kane BL, Rotman M, Berk L, Kachnic LA. Octreotide acetate in prevention of chemoradiation-induced diarrhea in anorectal cancer: randomized RTOG trial 0315. J Natl Cancer Inst. 2010 Apr;102(8):547-556. Pubmedid: 20339140. Pmcid: PMC2857801.
• Thomas KB, Simpson SL, Tarver WL, Gwede CK. Is social support from family associated with PSA testing? An exploratory analysis using the Health Information National Trends Survey (HINTS) 2005. Am J Mens Health. 2010 Mar;4(1):50-59. Pubmedid: 19477731.
• Vadaparampil ST, Quinn GP, Small BJ, McIntyre J, Loi CA, Closser Z, Gwede CK. A pilot study of hereditary breast and ovarian knowledge among a multiethnic group of Hispanic women with a personal or family history of cancer. Genet Test Mol Biomarkers. 2010 Feb;14(1):99-106. Pubmedid: 19929403. Pmcid: PMC2935838.
• Gwede CK, Ward BG, Luque JS, Vadaparampil ST, Rivers D, Martinez-Tyson D, Noel-Thomas S, Meade CD. Application of Geographic Information Systems and Asset Mapping to Facilitate Identification of Colorectal Cancer Screening Resources. Online J Public Health Inform. 2010 Jan;2(1):2893. Pubmedid: 20976019.
• Gwede CK, Ward BG, Luque JS, Vadaparampil ST, Rivers D, Martinez-Tyson D, Noel-Thomas S, Meade CD. Application of geographic information systems and asset mapping to facilitate identification of colorectal cancer screening resources. Online J Public Health Inform. 2010;2(1). Pubmedid: 23569578. Pmcid: PMC3615755.
• Murphy BA, Beaumont JL, Isitt J, Garden AS, Gwede CK, Trotti AM, Meredith RF, Epstein JB, Le QT, Brizel DM, Bellm LA, Wells N, Cella D. Mucositis-related morbidity and resource utilization in head and neck cancer patients receiving radiation therapy with or without chemotherapy. J Pain Symptom Manage. 2009 Oct;38(4):522-532. Pubmedid: 19608377.
• Gwede CK, Small BJ, Munster PN, Andrykowski MA, Jacobsen PB. Exploring the differential experience of breast cancer treatment-related symptoms: a cluster analytic approach. Support Care Cancer. 2008 Aug;16(8):925-933. Pubmedid: 18043948. Pmcid: PMC2892385.
• King L, Quinn G, Vadaparampil S, Gwede C, Miree C, Wilson C, Clayton H, Perrin K. Oncology nurses' perceptions of barriers to discussion of fertility preservation with patients with cancer. Clin J Oncol Nurs. 2008 Jun;12(3):467-476. Pubmedid: 18515245.
• Quinn G, Vadaparampil S, Bell-Ellison B, Gwede C, Albrecht T. Patient-physician communication barriers regarding fertility preservation among newly diagnosed cancer patients. Soc Sci Med. 2008 Feb;66(3):781-789. Pubmedid: 18023955.
• Trotti A, Pajak T, Gwede C, Paulus R, Cooper J, Forastiere A, Ridge J, Watkins-Bruner D, Garden A, Ang K, Curran W. TAME: development of a new method for summarising adverse events of cancer treatment by the Radiation Therapy Oncology Group. Lancet Oncol. 2007 Jul;8(7):613-624. Pubmedid: 17543584.
• Quinn GP, Vadaparampil ST, Gwede CK, Miree C, King LM, Clayton HB, Wilson C, Munster P. Discussion of fertility preservation with newly diagnosed patients: oncologists' views. J Cancer Surviv. 2007 Jun;1(2):146-155. Pubmedid: 18648955.
• Quinn G, Vadaparampil S, Gwede C, Miree C, King L, Clayton H, Wilson C, Munster P. Discussion of fertility preservation with newly diagnosed patients: oncologists' views. J Cancer Surviv. 2007 May;30(1):146-155.
• Xiao H, Gwede CK, Kiros G, Milla K. Analysis of prostate cancer incidence using geographic information system and multilevel modeling. J Natl Med Assoc. 2007 Mar;99(3):218-225. Pubmedid: 17393945. Pmcid: PMC2569639.
• Heysek R, Gwede C, Torres-Roca J, Cantor A, Kelley S, Saini A, Pow-Sang J. A dosimetric analysis of unstranded seeds versus customized stranded seeds in transperineal interstitial permanent prostate seed brachytherapy. Brachytherapy. 2006 Oct;5(4):244-250. Pubmedid: 17118318.
• Gwede C, Johnson D, Roberts C, Cantor A. Burnout in clinical research coordinators in the United States. Oncol Nurs Forum. 2005 Nov;32(5):1123-1130. Pubmedid: 16270108.
• Gwede C, Pow-Sang J, Seigne J, Heysek R, Helal M, Shade K, Cantor A, Jacobsen P. Treatment decision-making strategies and influences in patients with localized prostate carcinoma. Cancer. 2005 Oct;104(7):1381-1390. Pubmedid: 16080181.
• Soares HP, Kumar A, Daniels S, Swann S, Cantor A, Hozo I, Clark M, Serdarevic F, Gwede C, Trotti A, Djulbegovic B. Evaluation of new treatments in radiation oncology: are they better than standard treatments?. JAMA. 2005 Feb;293(8):970-978. Pubmedid: 15728168. Pmcid: PMC1779758.
• Gwede C. Overview of radiation- and chemoradiation-induced diarrhea. Semin Oncol Nurs. 2003;19:6-10. Pubmedid: 14702927.
• Trotti A, Bellm L, Epstein J, Frame D, Fuchs H, Gwede C, Komaroff E, Nalysnyk L, Zilberberg M. Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: a systematic literature review. Radiother Oncol. 2003;66(3):253-262. Pubmedid: 12742264.
• Gwede C, Johnson D, Daniels S, Trotti A. Assessment of toxicity in cooperative oncology clinical trials: the long and short of it. J Oncol Manag. 2002;11(2):15-21. Pubmedid: 11989815.
• Rose-Ped A, Bellm L, Epstein J, Trotti A, Gwede C, Fuch H. Complications of radiation therapy for head and neck cancer. The patient's perspective. Cancer Nurs. 2002;25(6):461-467. Pubmedid: 12464838.
• Gwede C, Forthofer M, McDermott R. Awareness of prostate cancer screening tests among African American men in underserved neighborhoods. J Oncol Manag. 2002;11(5):36-41. Pubmedid: 12382697.
• Zachariah B, Jacob S, Gwede C, Cantor A, Patil J, Casey L, Zachariah A. Effect of fractionated regional external beam radiotherapy on peripheral blood cell count. Int J Radiat Oncol Biol Phys. 2001;50(2):465-472. Pubmedid: 11380235.
• Smith M, Casey L, Johnson D, Gwede C, Riggin O. Music as a therapeutic intervention for anxiety in patients receiving radiation therapy. Oncol Nurs Forum. 2001;28(5):855-862. Pubmedid: 11421145.
• Trotti A, Byhardt R, Stetz J, Gwede C, Corn B, Fu K, Gunderson L, McCormic B, Morris M, Rich T, Shipley W, Curran W. Common toxicity criteria: version 2.0. an improved reference for grading the acute effects of cancer treatment: impact on radiotherapy. Int J Radiat Oncol Biol Phys. 2000;47(1):13-47. Pubmedid: 10758303.
• Trotti A, Johnson D, Gwede C, Casey L, Sauder B, Cantor A. Development of a head and neck companion module for the quality of life-radiation therapy instrument (QOL-RTI). Int J Radiat Oncol Biol Phys. 1998;42(2):257-261. Pubmedid: 9788402.
• Futran N, Trotti, III A, Gwede C. Pentoxifylline in the treatment of radiation-related soft tissue injury: preliminary observations. Lancet. 1997;107(3):391-395. Pubmedid: 9121320.
• Johnson D, Casey L, Gwede C, Friedland J, Trotti, III A. 1996;850-851.
• Gwede C, Friedland J, Johnson D, Casey L, Cantor A, Sauder B, Beres K. Validation of the quality of life-radiation therapy instrument (QOL-RTI) in patients receiving definitive radiation therapy for locally advanced prostate cancer. Int J Radiat Oncol Biol Phys. 1996;361(1):269-269.