Dr. Cogle's research focus is on the hemangioblast potential of normal and malignant hematopoietic stem/progenitor cells. Using unique mouse models of neovaculogenesis he discovered that adult human hematopoietic stem and progenitor cells generate both blood and blood vessels- adult hemangioblast activity. He has translated this discovery into novel therapies for cariovascular disease. His lab servces as an NIH Core Lab which assays bone marrow function in subject enrolled in cell therapy trials after myocardial infarction.
In addition, using animals models of cancer neovessel formation, he defined the role of the hematopoietic stem cell contributing to new blood vessels within cancers. Dr. Cogle is identifying critical pathways in how cancers co-opt the bone marrow for neovessell formation.
Dr. Cogle's lab also studies the co-dependent relationship between leukemia and blood vessels. Using xenotransplant modles of human leukemia, he tests novel anti-vascular strategies for the treatment of hematologic malignancies like acute myelogenous leukemia and myelodysplastic syndromes.