Chad A. Dickey, PhD

Where You Are:
Chad A. Dickey, PhD

Office  (813) 974-9577

Education And Training
  • Postdoctoral Fellow, Mayo Clinic, 2005 - Neuroscience
  • PhD, University of South Florida, 2004 - Biomedical Sciences
  • BS, University of South Florida, 1998 - Microbiology

We are also exploring the involvement of classical signaling cascades on chaperone-mediated signaling. The roles of the chaperones CHIP (carboxy-terminus of Hsc70-interacting protein) and Hsp90 (heat shock protein 90) are highly conserved throughout species and both proteins are critical for quality control and stress recovery systems in most cell types. CHIP is an ubiquitin ligase that is essential for mitigating stress-related proteins after a cellular stress response (1, 2) and has anti-apoptotic properties. Hsp90 has the unique ability to maintain mutated proteins in a folded and partially active state at the expense of ATP, permitting proteins that would otherwise be immediately targeted for degradation to persist within the cell. These proteins, referred to as clients, include a number of oncogenic and neurodegenerative associated proteins, such as ErbB2, mutant p53 and the tau protein, as well as critical components of breast cancer-related signaling pathways such as Akt. Small molecules aptly named Hsp90 inhibitors have been generated and functionally force these clients to be degraded through the proteasome (3-5). CHIP is a critical component for this degradation, and since it binds with both Hsp70 and Hsp90, it has an opportunity to interact with and ubiquitinate a number of proteins via their scaffold. Conversely, other chaperones and/or co-chaperones that are part of the complex at the time of the client/Hsp90 interaction can facilitate the ATPase activity of Hsp90, preserving the client substrate (6, 7). For example, tau and Akt degradation was prevented by deleting CHIP or Hsp90 (8), but tau degradation was enhanced by deleting prostaglandin E synthase 3 (P23), a co-chaperone that promotes re-folding or maintenance of Hsp90 clients. Therefore, we would like to investigate whether other co-chaperones may be involved with Akt and tau degradation. Perhaps identifying proteins that can facilitate the degradation of these proteins would provide novel targets to develop drugs that would reduce their levels rather than activity.

  • Blair LJ, Baker JD, Sabbagh JJ, Dickey CA. The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease. J Neurochem. 2015 Apr;133(1):1-13. Pubmedid: 25628064. Pmcid: PMC4361273.
  • Fontaine SN, Sabbagh JJ, Baker J, Martinez-Licha CR, Darling A, Dickey CA. Cellular factors modulating the mechanism of tau protein aggregation. Cell Mol Life Sci. 2015 Feb. Pubmedid: 25666877.
  • Martin MD, Calcul L, Smith C, Jinwal UK, Fontaine SN, Darling A, Seeley K, Wojtas L, Narayan M, Gestwicki JE, Smith GR, Reitz AB, Baker BJ, Dickey CA. Synthesis, Stereochemical Analysis, and Derivatization of Myricanol Provide New Probes That Promote Autophagic Tau Clearance. Acs Chem Biol. 2015 Jan. Pubmedid: 25588114.
  • Stothert AR, Suntharalingam A, Huard DJ, Fontaine S, Crowley V, Mishra S, Blagg B, Lieberman RL, Dickey CA. Exploiting the interaction between Grp94 and aggregated myocilin to treat glaucoma. Hum Mol Genet. 2014 Dec;23(24):6470-6480. Pubmedid: 25027323. Pmcid: PMC4240202.
  • Blair LJ, Sabbagh JJ, Dickey CA. Targeting Hsp90 and its co-chaperones to treat Alzheimer's disease. Expert Opin Ther Targets. 2014 Oct;18(10):1219-1232. Pubmedid: 25069659.
  • Selenica ML, Davtyan H, Housley SB, Blair LJ, Gillies A, Nordhues BA, Zhang B, Liu J, Gestwicki JE, Lee DC, Gordon MN, Morgan D, Dickey CA. Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis. J Neuroinflamm. 2014 Sep;11:152. Pubmedid: 25183004. Pmcid: PMC4167523.
  • Karagöz GE, Duarte AM, Akoury E, Ippel H, Biernat J, Morán Luengo T, Radli M, Didenko T, Nordhues BA, Veprintsev DB, Dickey CA, Mandelkow E, Zweckstetter M, Boelens R, Madl T, Rüdiger SG. Hsp90-Tau complex reveals molecular basis for specificity in chaperone action. Cell. 2014 Feb;156(5):963-974. Pubmedid: 24581495. Pmcid: PMC4263503.
  • Orwig SD, Chi PV, Du Y, Hill SE, Cavitt MA, Suntharalingam A, Turnage KC, Dickey CA, France S, Fu H, Lieberman RL. Ligands for glaucoma-associated myocilin discovered by a generic binding assay. Acs Chem Biol. 2014 Feb;9(2):517-525. Pubmedid: 24279319. Pmcid: PMC3944078.
  • O'Leary JC, Zhang B, Koren J, Blair L, Dickey CA. The role of FKBP5 in mood disorders: action of FKBP5 on steroid hormone receptors leads to questions about its evolutionary importance. CNS Neurol Disord Drug Targets. 2013 Dec;12(8):1157-1162. Pubmedid: 24040820. Pmcid: PMC4236834.
  • Selenica ML, Brownlow M, Jimenez JP, Lee DC, Pena G, Dickey CA, Gordon MN, Morgan D. Amyloid oligomers exacerbate tau pathology in a mouse model of tauopathy. Neurodegener Dis. 2013 Nov;11(4):165-181. Pubmedid: 22796753. Pmcid: PMC3739054.
  • Blair LJ, Nordhues BA, Hill SE, Scaglione KM, O'Leary JC, Fontaine SN, Breydo L, Zhang B, Li P, Wang L, Cotman C, Paulson HL, Muschol M, Uversky VN, Klengel T, Binder EB, Kayed R, Golde TE, Berchtold N, Dickey CA. Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. J Clin Invest. 2013 Oct;123(10):4158-4169. Pubmedid: 23999428. Pmcid: PMC3784538.
  • Smith MC, Scaglione KM, Assimon VA, Patury S, Thompson AD, Dickey CA, Southworth DR, Paulson HL, Gestwicki JE, Zuiderweg ER. The E3 ubiquitin ligase CHIP and the molecular chaperone Hsc70 form a dynamic, tethered complex. Biochemistry-Us. 2013 Aug;52(32):5354-5364. Pubmedid: 23865999. Pmcid: PMC3856692.
  • Miyata Y, Li X, Lee HF, Jinwal UK, Srinivasan SR, Seguin SP, Young ZT, Brodsky JL, Dickey CA, Sun D, Gestwicki JE. Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels. ACS Chem Neurosci. 2013 Jun;4(6):930-939. Pubmedid: 23472668. Pmcid: PMC3689201.
  • Lee DC, Ruiz CR, Lebson L, Selenica ML, Rizer J, Hunt JB, Rojiani R, Reid P, Kammath S, Nash K, Dickey CA, Gordon M, Morgan D. Aging enhances classical activation but mitigates alternative activation in the central nervous system. Neurobiol Aging. 2013 Jun;34(6):1610-1620. Pubmedid: 23481567. Pmcid: PMC3652232.
  • Abisambra JF, Jinwal UK, Blair LJ, O'Leary JC, Li Q, Brady S, Wang L, Guidi CE, Zhang B, Nordhues BA, Cockman M, Suntharalingham A, Li P, Jin Y, Atkins CA, Dickey CA. Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation. J Neurosci. 2013 May;33(22):9498-9507. Pubmedid: 23719816. Pmcid: PMC3733249.
  • Jinwal UK, Akoury E, Abisambra JF, O'Leary JC, Thompson AD, Blair LJ, Jin Y, Bacon J, Nordhues BA, Cockman M, Zhang J, Li P, Zhang B, Borysov S, Uversky VN, Biernat J, Mandelkow E, Gestwicki JE, Zweckstetter M, Dickey CA. Imbalance of Hsp70 family variants fosters tau accumulation. Faseb J. 2013 Apr;27(4):1450-1459. Pubmedid: 23271055. Pmcid: PMC3606536.
  • Braswell K, Dickey CA, Jinwal UK. A commentary on: Modulating molecular chaperones improves sensory fiber recovery and mitochondrial function in diabetic peripheral neuropathy. Exp Neurol. 2013 Mar;241:122-124. Pubmedid: 23298520.
  • Jinwal UK, Koren J, Dickey CA. Reconstructing the Hsp90/Tau Machine. Curr Enzym Inhib. 2013 Jan;9(1):41-45. Pubmedid: 23798910.
  • Chiosis G, Dickey CA, Johnson JL. A global view of Hsp90 functions. Nat Struct Mol Biol. 2013 Jan;20(1):1-4. Pubmedid: 23288357. Pmcid: PMC4004347.
  • Blair LJ, Zhang B, Dickey CA. Potential synergy between tau aggregation inhibitors and tau chaperone modulators. Alzheimers Res Ther. 2013;5(5):41. Pubmedid: 24041111. Pmcid: PMC3979086.
  • Miyata Y, Rauch JN, Jinwal UK, Thompson AD, Srinivasan S, Dickey CA, Gestwicki JE. Cysteine reactivity distinguishes redox sensing by the heat-inducible and constitutive forms of heat shock protein 70. Chem Biol. 2012 Nov;19(11):1391-1399. Pubmedid: 23177194. Pmcid: PMC3508472.
  • Suntharalingam A, Abisambra JF, O'Leary JC, Koren J, Zhang B, Joe MK, Blair LJ, Hill SE, Jinwal UK, Cockman M, Duerfeldt AS, Tomarev S, Blagg BS, Lieberman RL, Dickey CA. Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism. J Biol Chem. 2012 Nov;287(48):40661-40669. Pubmedid: 23035116. Pmcid: PMC3504779.
  • Thompson AD, Scaglione KM, Prensner J, Gillies AT, Chinnaiyan A, Paulson HL, Jinwal UK, Dickey CA, Gestwicki JE. Analysis of the tau-associated proteome reveals that exchange of hsp70 for hsp90 is involved in tau degradation. ACS Chem Biol. 2012 Oct;7(10):1677-1686. Pubmedid: 22769591.
  • Koren J, Miyata Y, Kiray J, O'Leary JC, Nguyen L, Guo J, Blair LJ, Li X, Jinwal UK, Cheng JQ, Gestwicki JE, Dickey CA. Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance. PLoS One. 2012 Sep;7(4):e35566. Pubmedid: 22563386. Pmcid: PMC3338522.
  • Calcul L, Zhang B, Jinwal UK, Dickey CA, Baker BJ. Natural products as a rich source of tau-targeting drugs for Alzheimer's disease. Future Med Chem. 2012 Sep;4(13):1751-1761. Pubmedid: 22924511. Pmcid: PMC3575183.
  • Abisambra JF, Jinwal UK, Suntharalingam A, Arulselvam K, Brady S, Cockman M, Jin Y, Zhang B, Dickey CA. DnaJA1 antagonizes constitutive Hsp70-mediated stabilization of tau. J Mol Biol. 2012 Aug;421(4-5):653-661. Pubmedid: 22343013. Pmcid: PMC3371317.
  • Jinwal UK, Abisambra JF, Zhang J, Dharia S, O'Leary JC, Patel T, Braswell K, Jani T, Gestwicki JE, Dickey CA. Cdc37/Hsp90 protein complex disruption triggers an autophagic clearance cascade for TDP-43 protein. J Biol Chem. 2012 Jul;287(29):24814-24820. Pubmedid: 22674575. Pmcid: PMC3397908.
  • Congdon EE, Wu JW, Myeku N, Figueroa YH, Herman M, Marinec PS, Gestwicki JE, Dickey CA, Yu WH, Duff KE. Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo. Autophagy. 2012 Apr;8(4):609-622. Pubmedid: 22361619. Pmcid: PMC3405840.
  • Daily JL, Nash K, Jinwal U, Golde T, Rogers J, Peters MM, Burdine RD, Dickey C, Banko JL, Weeber EJ. Adeno-associated virus-mediated rescue of the cognitive defects in a mouse model for Angelman syndrome. PLoS One. 2012 Apr;6(12):e27221. Pubmedid: 22174738. Pmcid: PMC3235088.
  • O'Leary JC, Dharia S, Blair LJ, Brady S, Johnson AG, Peters M, Cheung-Flynn J, Cox MB, de Erausquin G, Weeber EJ, Jinwal UK, Dickey CA. A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51. PLoS One. 2012 Feb;6(9):e24840. Pubmedid: 21935478. Pmcid: PMC3174203.
  • Koren J, Miyata Y, Kiray J, O'Leary JC, Nguyen L, Guo J, Blair LJ, Li X, Jinwal UK, Cheng JQ, Gestwicki JE, Dickey CA. Correction: Rhodacyanine Derivative Selectively Targets Cancer Cells and Overcomes Tamoxifen Resistance. PLoS One. 2012;7(7). Pubmedid: 22815661.
  • Storer CL, Dickey CA, Galigniana MD, Rein T, Cox MB. FKBP51 and FKBP52 in signaling and disease. Trends Endocrinol Metab. 2011 Dec;22(12):481-490. Pubmedid: 21889356. Pmcid: PMC3229651.
  • Abisambra JF, Jinwal UK, Jones JR, Blair LJ, Koren J, Dickey CA. Exploiting the diversity of the heat-shock protein family for primary and secondary tauopathy therapeutics. Curr Neuropharmacol. 2011 Dec;9(4):623-631. Pubmedid: 22654720. Pmcid: PMC3263456.
  • O'Leary JC, Koren J, Dickey CA. Neuronal life span versus health span: principles of natural selection at work in the degenerating brain. J Mol Neurosci. 2011 Nov;45(3):467-472. Pubmedid: 21559875. Pmcid: PMC4235992.
  • Voss K, Koren J, Dickey CA. The earliest tau dysfunction in Alzheimer's disease? Tau phosphorylated at s422 as a toxic seed. Am J Pathol. 2011 Nov;179(5):2148-2151. Pubmedid: 21964186. Pmcid: PMC3204013.
  • Trotter JH, Klein M, Jinwal UK, Abisambra JF, Dickey CA, Tharkur J, Masiulis I, Ding J, Locke KG, Rickman CB, Birch DG, Weeber EJ, Herz J. ApoER2 function in the establishment and maintenance of retinal synaptic connectivity. J Neurosci. 2011 Oct;31(40):14413-14423. Pubmedid: 21976526. Pmcid: PMC3224795.
  • Miyata Y, Koren J, Kiray J, Dickey CA, Gestwicki JE. Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies. Future Med Chem. 2011 Sep;3(12):1523-1537. Pubmedid: 21882945. Pmcid: PMC3190966.
  • Koren J, Jinwal UK, Davey Z, Kiray J, Arulselvam K, Dickey CA. Bending tau into shape: the emerging role of peptidyl-prolyl isomerases in tauopathies. Mol Neurobiol. 2011 Aug;44(1):65-70. Pubmedid: 21523562. Pmcid: PMC3260650.
  • Rousaki A, Miyata Y, Jinwal UK, Dickey CA, Gestwicki JE, Zuiderweg ER. Allosteric drugs: the interaction of antitumor compound MKT-077 with human Hsp70 chaperones. J Mol Biol. 2011 Aug;411(3):614-632. Pubmedid: 21708173. Pmcid: PMC3146629.
  • O'Leary JC, Li Q, Marinec P, Blair LJ, Congdon EE, Johnson AG, Jinwal UK, Koren J, Jones JR, Kraft C, Peters M, Abisambra JF, Duff KE, Weeber EJ, Gestwicki JE, Dickey CA. Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden. Mol Neurodegener. 2011 Jul;5:45. Pubmedid: 21040568. Pmcid: PMC2989315.
  • Jinwal UK, Trotter JH, Abisambra JF, Koren J, Lawson LY, Vestal GD, O'Leary JC, Johnson AG, Jin Y, Jones JR, Li Q, Weeber EJ, Dickey CA. The Hsp90 kinase co-chaperone Cdc37 regulates tau stability and phosphorylation dynamics. J Biol Chem. 2011 May;286(19):16976-16983. Pubmedid: 21367866. Pmcid: PMC3089541.
  • Jones JR, Lebar MD, Jinwal UK, Abisambra JF, Koren J, Blair L, O'Leary JC, Davey Z, Trotter J, Johnson AG, Weeber E, Eckman CB, Baker BJ, Dickey CA. The diarylheptanoid (+)-aR,11S-myricanol and two flavones from bayberry (Myrica cerifera) destabilize the microtubule-associated protein tau. J Nat Prod. 2011 Jan;74(1):38-44. Pubmedid: 21141876. Pmcid: PMC3070757.
  • Evans CG, Jinwal UK, Makley LN, Dickey CA, Gestwicki JE. Identification of dihydropyridines that reduce cellular tau levels. Chem Commun (Camb). 2011 Jan;47(1):529-531. Pubmedid: 21082080. Pmcid: PMC3251959.
  • Jinwal UK, Dickey CA. Cell-based assays for regulators of tau biology. Methods Mol Biol. 2011;670:93-108. Pubmedid: 20967586.
  • Carty N, Lee D, Dickey C, Ceballos-Diaz C, Jansen-West K, Golde TE, Gordon MN, Morgan D, Nash K. Convection-enhanced delivery and systemic mannitol increase gene product distribution of AAV vectors 5, 8, and 9 and increase gene product in the adult mouse brain. J Neurosci Meth. 2010 Dec;194(1):144-153. Pubmedid: 20951738. Pmcid: PMC2995441.
  • Lee DC, Rizer J, Selenica ML, Reid P, Kraft C, Johnson A, Blair L, Gordon MN, Dickey CA, Morgan D. LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice. J Neuroinflamm. 2010 Dec;7:56. Pubmedid: 20846376. Pmcid: PMC2949628.
  • Abisambra JF, Blair LJ, Hill SE, Jones JR, Kraft C, Rogers J, Koren J, Jinwal UK, Lawson L, Johnson AG, Wilcock D, O'Leary JC, Jansen-West K, Muschol M, Golde TE, Weeber EJ, Banko J, Dickey CA. Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice. J Neurosci. 2010 Nov;30(46):15374-15382. Pubmedid: 21084594. Pmcid: PMC3073547.
  • Lebson L, Nash K, Kamath S, Herber D, Carty N, Lee DC, Li Q, Szekeres K, Jinwal U, Koren J, Dickey CA, Gottschall PE, Morgan D, Gordon MN. Trafficking CD11b-positive blood cells deliver therapeutic genes to the brain of amyloid-depositing transgenic mice. J Neurosci. 2010 Jul;30(29):9651-9658. Pubmedid: 20660248. Pmcid: PMC2929651.
  • Jinwal UK, O'Leary JC, Borysov SI, Jones JR, Li Q, Koren J, Abisambra JF, Vestal GD, Lawson LY, Johnson AG, Blair LJ, Jin Y, Miyata Y, Gestwicki JE, Dickey CA. Hsc70 rapidly engages tau after microtubule destabilization. J Biol Chem. 2010 May;285(22):16798-16805. Pubmedid: 20308058. Pmcid: PMC2878041.
  • Heal MR, Dickey CA, Heal KV, Stidson RT, Matucha M, Cape JN. The production and degradation of trichloroacetic acid in soil: results from in situ soil column experiments. Chemosphere. 2010 Apr;79(4):401-407. Pubmedid: 20172585.
  • Jinwal UK, Koren J, O'Leary JC, Jones JR, Abisambra JF, Dickey CA. Hsp70 ATPase Modulators as Therapeutics for Alzheimer's and other Neurodegenerative Diseases. Mol Cell Pharmacol. 2010 Jan;2(2):43-46. Pubmedid: 20523917. Pmcid: PMC2879647.
  • Jinwal UK, Koren J, Borysov SI, Schmid AB, Abisambra JF, Blair LJ, Johnson AG, Jones JR, Shults CL, O'Leary JC, Jin Y, Buchner J, Cox MB, Dickey CA. The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules. J Neurosci. 2010 Jan;30(2):591-599. Pubmedid: 20071522. Pmcid: PMC2830818.
  • Koren J, Jinwal UK, Jin Y, O'Leary J, Jones JR, Johnson AG, Blair LJ, Abisambra JF, Chang L, Miyata Y, Cheng AM, Guo J, Cheng JQ, Gestwicki JE, Dickey CA. Facilitating Akt clearance via manipulation of Hsp70 activity and levels. J Biol Chem. 2010 Jan;285(4):2498-2505. Pubmedid: 19889640. Pmcid: PMC2807306.
  • Jinwal UK, Miyata Y, Koren J, Jones JR, Trotter JH, Chang L, O'Leary J, Morgan D, Lee DC, Shults CL, Rousaki A, Weeber EJ, Zuiderweg ER, Gestwicki JE, Dickey CA. Chemical manipulation of hsp70 ATPase activity regulates tau stability. J Neurosci. 2009 Sep;29(39):12079-12088. Pubmedid: 19793966. Pmcid: PMC2775811.
  • Koren J, Jinwal UK, Lee DC, Jones JR, Shults CL, Johnson AG, Anderson LJ, Dickey CA. Chaperone signalling complexes in Alzheimer's disease. J Cell Mol Med. 2009 Apr;13(4):619-630. Pubmedid: 19449461. Pmcid: PMC2749087.
  • Dickey C, Kraft C, Jinwal U, Koren J, Johnson A, Anderson L, Lebson L, Lee D, Dickson D, de Silva R, Binder LI, Morgan D, Lewis J. Aging analysis reveals slowed tau turnover and enhanced stress response in a mouse model of tauopathy. Am J Pathol. 2009 Feb;174(1):228-238. Pubmedid: 19074615. Pmcid: PMC2631335.
  • Dickey CA, Koren J, Zhang YJ, Xu YF, Jinwal UK, Birnbaum MJ, Monks B, Sun M, Cheng JQ, Patterson C, Bailey RM, Dunmore J, Soresh S, Leon C, Morgan D, Petrucelli L. Akt and CHIP coregulate tau degradation through coordinated interactions. Proc Natl Acad Sci U S A. 2008 Mar;105(9):3622-3627. Pubmedid: 18292230. Pmcid: PMC2265134.
  • Zhang YJ, Xu YF, Dickey CA, Buratti E, Baralle F, Bailey R, Pickering-Brown S, Dickson D, Petrucelli L. Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43. J Neurosci. 2007 Sep;27(39):10530-10534. Pubmedid: 17898224.
  • Karlnoski R, Wilcock D, Dickey C, Ronan V, Gordon MN, Zhang W, Morgan D, Taglialatela G. Up-regulation of Bcl-2 in APP transgenic mice is associated with neuroprotection. Neurobiol Dis. 2007 Jan;25(1):179-188. Pubmedid: 17067805. Pmcid: PMC1885419.
  • Dickey CA, Yue M, Lin WL, Dickson DW, Dunmore JH, Lee WC, Zehr C, West G, Cao S, Clark AM, Caldwell GA, Caldwell KA, Eckman C, Patterson C, Hutton M, Petrucelli L. Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species. J Neurosci. 2006 Jun;26(26):6985-6996. Pubmedid: 16807328.
  • Dickey CA, Dunmore J, Lu B, Wang JW, Lee WC, Kamal A, Burrows F, Eckman C, Hutton M, Petrucelli L. HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites. FASEB J. 2006 Apr;20(6):753-755. Pubmedid: 16464956.
  • Dickey CA, Gordon MN, Wilcock DM, Herber DL, Freeman MJ, Morgan D. Dysregulation of Na+/K+ ATPase by amyloid in APP+PS1 transgenic mice. BMC Neurosci. 2006 Apr;6:7. Pubmedid: 15689237. Pmcid: PMC549198.
  • Lee WC, Courtenay A, Troendle FJ, Stallings-Mann ML, Dickey CA, DeLucia MW, Dickson DW, Eckman CB. Enzyme replacement therapy results in substantial improvements in early clinical phenotype in a mouse model of globoid cell leukodystrophy. FASEB J. 2005 Sep;19(11):1549-1551. Pubmedid: 15987783.
  • Garcia M, Gordon M, Hutton M, Lewis J, McGowan E, Dickey C, Morgan D, Arendash G. The retinal degeneration (rd) gene seriously impairs spatial cognitive performance in normal and Alzheimer's transgenic mice. Neuroreport. 2004;15(1):73-77. Pubmedid: 15106834.
  • Dickey C, De Mesquita D, Morgan D, Pennypacker K. Induction of memory-associated immediate early genes by nerve growth factor in rat primary cortical neurons and differentiated mouse Neuro2A cells. Neurosci Lett. 2004;366(1):10-14. Pubmedid: 15265580.
  • Dickey C, Gordon M, Mason J, Wilson N, Diamond D, Guzowski J, Morgan D. Amyloid suppresses induction of genes critical for memory consolidation in APP + PS1 transgenic mice. J Neurochem. 2004;88(2):434-442. Pubmedid: 14690531.
  • Dickey CA, Morgan DG, Kudchodkar S, Weiner DB, Bai Y, Cao C, Gordon MN, Ugen KE. Duration and specificity of humoral immune responses in mice vaccinated with the Alzheimer's disease-associated beta-amyloid 1-42 peptide. DNA Cell Biol. 2001 Nov;20(11):723-729. Pubmedid: 11788050.
  • Wilcock D, Gordon M, Ugen K, Gottschall P, DiCarlo G, Dickey C, BoyettKW, Jantzen P, Connor K, Melachrino J, Hardy J, Morgan D. Number of Abeta inoculations in APP+PS1 transgenic mice influences antibody titers, microglial activation, and congophilic plaque levels. Dna Cell Biol. 2001;20(11):731-736. Pubmedid: 11788051.
  • Morgan D, Diamond D, Gottschall P, Ugen K, Dickey C, Hardy J, Duff K, Jantzen P, DiCarlo G, Wilcock D, Connor K, Hatcher J, Hope C, Gordon M, Arendash GW. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature. 2000;408(6815):982-985. Pubmedid: 11140686.
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