Bill J. Baker, PhD

Where You Are:
Bill J. Baker, PhD

Office  (813) 745-1967

Education And Training
  • Fellow, Stanford University, 1990 - Chemistry, Biosynthesis
  • Fellow, Rice University, 1989 - Chemistry, Biosynthesis
  • PhD, University of Hawaii at Manoa, 1986 - Chemistry

Analysis of secondary metobolites from marine invertebrates, macroalgae and microorganisms, including chomatographic and spectroscopic characterization; drug discovery, including anti-infective and anti-cancer disease areas and multi-drug resistance; marine biotechnology; chemical ecology of marine organisms; generation of chemical diversity; biosynthesis of marine natural products; synthesis of marine natural products; agrochemical applications of marine natural products.

  • Young RM, Burkett-Cadena ND, McGaha TW, Rodriguez-Perez MA, Toé LD, Adeleke MA, Sanfo M, Soungalo T, Katholi CR, Noblet R, Fadamiro H, Torres-Estrada JL, Salinas-Carmona MC, Baker B, Unnasch TR, Cupp EW. Identification of human semiochemicals attractive to the major vectors of onchocerciasis. PLoS Negl Trop Dis. 2015 Jan;9(1):e3450. Pubmedid: 25569240. Pmcid: PMC4287528.
  • McGaha TW, Young RM, Burkett-Cadena ND, Iburg JP, Beau JM, Hassan S, Katholi CR, Cupp EW, Baker BJ, Unnasch TR, Noblet R. Identification of Communal Oviposition Pheromones from the Black Fly Simulium vittatum. PLoS One. 2015;10(3):e0118904. Pubmedid: 25786206. Pmcid: PMC4364695.
  • Waterman C, Calcul L, Beau J, Ma WS, Lebar MD, von Salm JL, Harter C, Mutka T, Morton LC, Maignan P, Barisic B, von Olphen A, Kyle DE, Vrijmoed L, Pang KL, Pearce CJ, Baker BJ. Miniaturized Cultivation of Microbiota for Antimalarial Drug Discovery. Med Res Rev. 2014 Dec. Pubmedid: 25545963.
  • von Salm JL, Wilson NG, Vesely BA, Kyle DE, Cuce J, Baker BJ. Shagenes A and B, new tricyclic sesquiterpenes produced by an undescribed Antarctic octocoral. Org Lett. 2014 May;16(10):2630-2633. Pubmedid: 24779517. Pmcid: PMC4127331.
  • Young RM, von Salm JL, Amsler MO, Lopez-Bautista J, Amsler CD, McClintock JB, Baker BJ. Site-specific variability in the chemical diversity of the Antarctic red alga Plocamium cartilagineum. Mar Drugs. 2013 Jun;11(6):2126-2139. Pubmedid: 23771046. Pmcid: PMC3721224.
  • Wilson NG, Maschek JA, Baker BJ. A species flock driven by predation? Secondary metabolites support diversification of slugs in antarctica. PLoS One. 2013;8(11):e80277. Pubmedid: 24303002. Pmcid: PMC3841181.
  • Calcul L, Zhang B, Jinwal UK, Dickey CA, Baker BJ. Natural products as a rich source of tau-targeting drugs for Alzheimer's disease. Future Med Chem. 2012 Sep;4(13):1751-1761. Pubmedid: 22924511. Pmcid: PMC3575183.
  • Noguez JH, Diyabalanage TK, Miyata Y, Xie XS, Valeriote FA, Amsler CD, McClintock JB, Baker BJ. Palmerolide macrolides from the Antarctic tunicate Synoicum adareanum. Bioorg Med Chem. 2011 Nov;19(22):6608-6614. Pubmedid: 21737286.
  • Jones JR, Lebar MD, Jinwal UK, Abisambra JF, Koren J, Blair L, O'Leary JC, Davey Z, Trotter J, Johnson AG, Weeber E, Eckman CB, Baker BJ, Dickey CA. The diarylheptanoid (+)-aR,11S-myricanol and two flavones from bayberry (Myrica cerifera) destabilize the microtubule-associated protein tau. J Nat Prod. 2011 Jan;74(1):38-44. Pubmedid: 21141876. Pmcid: PMC3070757.
  • McClintock JB, Amsler CD, Moran AL, Woods HA, Baker BJ. Introduction to the symposium: advances in antarctic marine biology. Integr Comp Biol. 2010 Dec;50(6):948-949. Pubmedid: 21558251.
  • McClintock JB, Amsler CD, Baker BJ. Overview of the Chemical Ecology of Benthic Marine Invertebrates along the Western Antarctic Peninsula. Integr Comp Biol. 2010 Dec;50(6):967-980. Pubmedid: 21558253.
  • Diyabalanage T, Iken KB, McClintock JB, Amsler CD, Baker BJ. Palmadorins A--C, diterpene glycerides from the antarctic nudibranch Austrodoris kerguelenensis. J Nat Prod. 2010 Mar;73(3):416-421. Pubmedid: 20121160.
  • Ma WS, Mutka T, Vesley B, Amsler MO, McClintock JB, Amsler CD, Perman JA, Singh MP, Maiese WM, Zaworotko MJ, Kyle DE, Baker BJ. Norselic acids A-E, highly oxidized anti-infective steroids that deter mesograzer predation, from the Antarctic Sponge Crella sp. J Nat Prod. 2009 Oct;72(10):1842-1846. Pubmedid: 19848433.
  • Miyata Y, Diyabalanage T, Amsler C, McClintock J, Valeriote F, Baker B. Ecdysteroids from the Antarctic Tunicate Synoicum adareanum. J Nat Prod. 2007 Dec;70(12):1859-1864. Pubmedid: 18039009.
  • Lebar MF, Heimbegner JL, Baker BJ. Cold-water marine natural products. Nat Prod Rep. 2007 Aug;24(4):774-797. Pubmedid: 17653359.
  • Baker B. Instant insight: in from the cold. Dalton Trans. 2007 Jun;(23):C47-C47. Pubmedid: 17844655.
  • Baker B. In from the cold. Chem Commun (Camb). 2007 Jun;(23):C47-C47. Pubmedid: 17844734.
  • Diyabalanage T, Amsler C, McClintock J, Baker B. Palmerolide a, a cytotoxic macrolide from the antarctic tunicate synoicumadareanum. 2006 May;128(17):5630-5631. Pubmedid: 16637618.
  • Ankisetty S, Nandiraju S, Win H, Park YC, Amsler CD, McClintock JB, Baker JA, Diyabalanage TK, Pasaribu A, Singh MP, Maiese WM, Walsh RD, Zaworotko MJ, Baker BJ. Chemical investigation of predator-deterred macroalgae from the Antarctic peninsula. J Nat Prod. 2004 Aug;67(8):1295-1302. Pubmedid: 15332845.
  • Ankisetty S, Amsler C, McClintock J, Baker B. Further membranolide diterpenes from the antarctic sponge dendrilla membranosa. J Nat Prod. 2004;67(7):1172-1174. Pubmedid: 15270575.
  • Iken K, Baker B. Ainigmaptilones, sesquiterpenes from the Antarctic gorgonian coral Ainigmaptilon antarcticus. J Nat Prod. 2003;66(6):888-890. Pubmedid: 12828486.
  • MacGregor BJ, Moser DP, Baker BJ, Alm EW, Maurer M, Nealson KH, Stahl DA. Seasonal and spatial variability in Lake Michigan sediment small-subunit rRNA concentrations. Appl Environ Microbiol. 2001 Sep;67(9):3908-3922. Pubmedid: 11525985. Pmcid: PMC93109.
  • Dinesh-Kumar SP, Tham WH, Baker BJ. Structure-function analysis of the tobacco mosaic virus resistance gene N. Proc Natl Acad Sci U S A. 2000 Dec;97(26):14789-14794. Pubmedid: 11121079. Pmcid: PMC18997.
  • Dinesh-Kumar SP, Baker BJ. Alternatively spliced N resistance gene transcripts: their possible role in tobacco mosaic virus resistance. Proc Natl Acad Sci U S A. 2000 Feb;97(4):1908-1913. Pubmedid: 10660679. Pmcid: PMC26535.
  • Erickson FL, Dinesh-Kumar SP, Holzberg S, Ustach CV, Dutton M, Handley V, Corr C, Baker BJ. Interactions between tobacco mosaic virus and the tobacco N gene. Philos Trans R Soc Lond B Biol Sci. 1999 Mar;354(1383):653-658. Pubmedid: 10212945. Pmcid: PMC1692539.
  • Honma MA, Baker BJ, Waddell CS. High-frequency germinal transposition of DsALS in Arabidopsis. Proc Natl Acad Sci U S A. 1993 Jul;90(13):6242-6246. Pubmedid: 8392193. Pmcid: PMC46904.
  • Czernilofsky AP, Hain R, Herrera-Estrella L, Lörz H, Goyvaerts E, Baker BJ, Schell J. Fate of selectable marker DNA integrated into the genome of Nicotiana tabacum. DNA. 1986 Apr;5(2):101-113. Pubmedid: 3519133.
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