Barbara A. Centeno, MD

Where You Are:
Barbara A. Centeno, MD

Senior Member

Office  (813) 745-2451

Education And Training
  • Fellow, Massachusetts General Hospital, Boston, MA, 1993 - Cytopathology
  • Resident, Massachusetts General Hospital, Boston, MA, 1992 - Anatomic Pathology
  • MD, Johns Hopkins University School of Medicine, Baltimore, Maryland, 1988
  • BA, University of Miami, Coral Gables, Florida, 1984

One of Dr. Centeno's research interests is the study of the molecular progression of pancreatic cancer, which could lead to the identification of targets for early detection and directed therapy. Dr. Centeno is also working on the development of a tumor classifier using gene expression profiling for carcinoma of unknown primary in the liver. Her goal is to expand the application of novel markers and tumor classifiers to the limited cellular samples obtained with fine needle aspiration samples.

  • Permuth-Wey J, Chen YA, Fisher K, McCarthy S, Qu X, Lloyd MC, Kasprzak A, Fournier M, Williams VL, Ghia KM, Yoder SJ, Hall L, Georgeades C, Olaoye F, Husain K, Springett GM, Chen DT, Yeatman T, Centeno BA, Klapman J, Coppola D, Malafa M. A genome-wide investigation of microRNA expression identifies biologically-meaningful microRNAs that distinguish between high-risk and low-risk intraductal papillary mucinous neoplasms of the pancreas. PLoS One. 2015 Jan;10(1):e0116869. Pubmedid: 25607660. Pmcid: PMC4301643.
  • Pimiento JM, Chen DT, Centeno BA, Davis-Yadley AH, Husain K, Fulp WJ, Wang C, Zhang A, Malafa MP. Annexin A8 Is a Prognostic Marker and Potential Therapeutic Target for Pancreatic Cancer. Pancreas. 2015 Jan;44(1):122-127. Pubmedid: 25268673. Pmcid: PMC4262713.
  • Wong J, Fulp WJ, Strosberg JR, Kvols LK, Centeno BA, Hodul PJ. Predictors of lymph node metastases and impact on survival in resected pancreatic neuroendocrine tumors: a single-center experience. Am J Surg. 2014 Nov;208(5):775-780. Pubmedid: 24997491.
  • Morse B, Centeno B, Vignesh S. Autoimmune pancreatitis: updated concepts of a challenging diagnosis. Am J Med. 2014 Oct;127(10):1010.e1-1010.e9. Pubmedid: 24835039.
  • Brand RE, Adai AT, Centeno BA, Lee LS, Rateb G, Vignesh S, Menard C, Wiechowska-Kozlowska A, Boldys H, Hartleb M, Sanders MK, Munding JB, Tannapfel A, Hahn SA, Stefańczyk L, Tsongalis GJ, Whitcomb DC, Conwell DL, Morisset JA, Gardner TB, Gordon SR, Suriawinata AA, Lloyd MB, Wylie D, Labourier E, Andruss BF, Szafranska-Schwarzbach AE. A MicroRNA-Based Test Improves Endoscopic Ultrasound-Guided Cytologic Diagnosis of Pancreatic Cancer. Clin Gastroenterol H. 2014 Oct;12(10):1717-1723. Pubmedid: 24662333.
  • Pitman MB, Centeno BA, Ali SZ, Genevay M, Stelow E, Mino-Kenudson M, Castillo CF, Schmidt CM, Brugge WR, Layfield LJ. Standardized terminology and nomenclature for pancreatobiliary cytology: The Papanicolaou Society of Cytopathology Guidelines. Cytojournal. 2014 SEP;11(Suppl 1):3. Pubmedid: 25191517. Pmcid: PMC4153338.
  • Pitman MB, Centeno BA, Ali SZ, Genevay M, Stelow E, Mino-Kenudson M, Fernandez-Del Castillo C, Max Schmidt C, Brugge W, Layfield L. Standardized terminology and nomenclature for pancreatobiliary cytology: The Papanicolaou Society of Cytopathology guidelines. Diagn Cytopathol. 2014 Apr;42(4):338-350. Pubmedid: 24554455.
  • Pitman MB, Centeno BA, Daglilar ES, Brugge WR, Mino-Kenudson M. Cytological criteria of high-grade epithelial atypia in the cyst fluid of pancreatic intraductal papillary mucinous neoplasms. Cancer Cytopathol. 2014 Jan;122(1):40-47. Pubmedid: 23939829.
  • Trevino JG, Verma M, Singh S, Pillai S, Zhang D, Pernazza D, Sebti SM, Lawrence NJ, Centeno BA, Chellappan SP. Selective disruption of rb-raf-1 kinase interaction inhibits pancreatic adenocarcinoma growth irrespective of gemcitabine sensitivity. Mol Cancer Ther. 2013 Dec;12(12):2722-2734. Pubmedid: 24107447. Pmcid: PMC3858536.
  • Pitman MB, Centeno BA, Genevay M, Fonseca R, Mino-Kenudson M. Grading epithelial atypia in endoscopic ultrasound-guided fine-needle aspiration of intraductal papillary mucinous neoplasms: an international interobserver concordance study. Cancer Cytopathol. 2013 Dec;121(12):729-736. Pubmedid: 23881863.
  • Saranga-Perry V, Morse B, Centeno B, Kvols L, Strosberg J. Treatment of Metastatic Neuroendocrine Tumors of the Thymus with Capecitabine and Temozolomide: A Case Series. Neuroendocrinology. 2013 Jan. Pubmedid: 23296364.
  • Wong J, Weber J, A Centeno B, Vignesh S, Harris CL, Klapman JB, Hodul P. High-Grade Dysplasia and Adenocarcinoma Are Frequent in Side-Branch Intraductal Papillary Mucinous Neoplasm Measuring Less than 3 cm on Endoscopic Ultrasound. J Gastrointest Surg. 2013 Jan;17(1):78-85. Pubmedid: 22948841.
  • House JC, Henderson-Jackson EB, Johnson JO, Lloyd MC, Dhillon J, Ahmad N, Hakam A, Khalbuss WE, Leon ME, Chhieng D, Zhang X, Centeno BA, Bui MM. Diagnostic digital cytopathology: Are we ready yet?. J Pathol Inform. 2013;4:28. Pubmedid: 24392242. Pmcid: PMC3869956.
  • Trevino JG, Pillai S, Kunigal S, Singh S, Fulp WJ, Centeno BA, Chellappan SP. Nicotine induces inhibitor of differentiation-1 in a Src-dependent pathway promoting metastasis and chemoresistance in pancreatic adenocarcinoma. Neoplasia. 2012 Dec;14(12):1102-1114. Pubmedid: 23308043. Pmcid: PMC3540937.
  • Helm J, Coppola D, Ganapathy V, Lloyd M, Centeno BA, Chen DT, Malafa MP, Park JY. SLC5A8 Nuclear Translocation and Loss of Expression are Associated With Poor Outcome in Pancreatic Ductal Adenocarcinoma. Pancreas. 2012 Aug;41(6):904-909. Pubmedid: 22450368.
  • Kucera S, Centeno BA, Springett G, Malafa MP, Chen YA, Weber J, Klapman J. Cyst Fluid Carcinoembryonic Antigen Level Is not Predictive of Invasive Cancer in Patients with Intraductal Papillary Mucinous Neoplasm of the Pancreas. JOP. 2012 Jul;13(4):409-413. Pubmedid: 22797397.
  • Mathew BM, Daas AY, Centeno BA, Hoffe S, Valone T, Patel M, Springett GM. Lessons learned from a complete remission of advanced metastatic pancreatic ductal adenocarcinoma. Clin Adv Hematol Oncol. 2012 May;10(5):340-343. Pubmedid: 22706548.
  • Patel M, Hoffe S, Malafa M, Hodul P, Klapman J, Centeno B, Kim J, Helm J, Valone T, Springett G. Neoadjuvant GTX chemotherapy and IMRT-based chemoradiation for borderline resectable pancreatic cancer. J Surg Oncol. 2011 Aug;104(2):155-161. Pubmedid: 21520097. Pmcid: PMC3347705.
  • Centeno BA, Bloom G, Chen DT, Chen Z, Gruidl M, Nasir A, Yeatman TY. Hybrid model integrating immunohistochemistry and expression profiling for the classification of carcinomas of unknown primary site. J Mol Diagn. 2010 Jul;12(4):476-486. Pubmedid: 20558571. Pmcid: PMC2893632.
  • Helm J, Centeno BA, Coppola D, Melis M, Lloyd M, Park JY, Chen DT, Malafa MP. Histologic characteristics enhance predictive value of American Joint Committee on Cancer staging in resectable pancreas cancer. Cancer. 2009 Sep;115(18):4080-4089. Pubmedid: 19626671.
  • Munster P, Marchion D, Bicaku E, Lacevic M, Kim J, Centeno B, Daud A, Neuger A, Minton S, Sullivan D. Clinical and biological effects of valproic acid as a histone deacetylase inhibitor on tumor and surrogate tissues: phase I/II trial of valproic acid and epirubicin/FEC. Clin Cancer Res. 2009 Apr;15(7):2488-2496. Pubmedid: 19318486.
  • Helm J, Centeno B, Coppola D, Druta M, Park J, Chen D, Hodul P, Kvols LK, Yeatman T, Carey L, Karl R, Malafa M. Outcomes following resection of pancreatic adenocarcinoma: 20-year experience at a single institution. Cancer Control. 2008 Oct;15(4):288-294. Pubmedid: 18813196.
  • Nair R, Barthel J, Centeno B, Choi J, Klapman J, Malafa M. Interdisciplinary management of an intraductal papillary mucinous neoplasm of the pancreas. Cancer Control. 2008 Oct;15(4):322-333. Pubmedid: 18813200.
  • Cangiano J, Centeno BA, Garrett CR, Caceres W, de Jesus A, Lee JH, Pavia O, Jove R, Baez L, Sullivan DM, Muro-Cacho CA, Munoz-Antonia T. Signal transduction proteins in tumors from Puerto Rican and Caucasian gastric adenocarcinoma patients: expression differences with potential for specific targeted therapies. Digest Dis Sci. 2008 Aug;53(8):2090-2100. Pubmedid: 18224443.
  • Park J, Helm J, Zheng W, Ly Q, Hodul P, Centeno B, Malafa M. Silencing of the candidate tumor suppressor gene solute carrier family 5 member 8 (SLC5A8) in human pancreatic cancer. Pancreas. 2008 May;36(4):e32-e39. Pubmedid: 18437076.
  • Ma C, Rong Y, Radiloff DR, Datto MB, Centeno B, Bao S, Cheng AW, Lin F, Jiang S, Yeatman TJ, Wang XF. Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation. Gene Dev. 2008 Feb;22(3):308-321. Pubmedid: 18245446. Pmcid: PMC2216691.
  • Hernandez J, Centeno B, Kelley S. Solid pseudopapillary tumors of the pancreas: case presentation and review of the literature. Am Surg. 2007 Mar;73(3):290-293. Pubmedid: 17375791.
  • Yendluri V, Centeno B, Springett G. Pancreatic cancer presenting as a Sister Mary Joseph's nodule: case report and update of the literature. Pancreas. 2007 Jan;34(1):161-164. Pubmedid: 17198200.
  • Yan P, Venkataramu C, Ibrahim A, Liu J, Shen R, Diaz N, Centeno B, Weber F, Leu Y, Shapiro C, Eng C, Yeatman T, Huang T. Mapping geographic zones of cancer risk with epigenetic biomarkers in normal breast tissue. Clin Cancer Res. 2006 Nov;12(22):6626-6636. Pubmedid: 17121881.
  • Centeno B. Pathology of liver metastases. Cancer Control. 2006 Jan;13(1):13-26. Pubmedid: 16508622.
  • Nasir A, Stridsberg M, Strosberg J, Su P, Livingston S, Malik H, Kelley ST, Centeno B, Coppola D, Malafa M, Yeatman T, Kvols L. Somatostatin receptor profiling in hepatic metastases from small intestinal and pancreatic neuroendocrine neoplasms: immunohistochemical approach with potential clinical utility. Cancer Control. 2006 Jan;13(1):52-60. Pubmedid: 16508627.
  • Daud A, Valkov N, Centeno B, Derderian J, Sullivan P, Munster P, Urbas P, Deconti R, Berghorn E, Liu Z, Hausheer F, Sullivan D. Phase II trial of karenitecin in patients with malignant melanoma: clinical and translational study. Clin Cancer Res. 2005 Apr;11(8):3009-3016. Pubmedid: 15837755.
  • Centeno B, Enkemann S, Coppola D, Huntsman S, Bloom G, Yeatman T. Classification of human tumors using gene expression profiles obtained after microarray analysis of fine-needle aspiration biopsy samples. Cancer. 2005 Apr;105(2):101-109. Pubmedid: 15643601.
  • Cox C, Centeno B, Dickson D, Clark J, Nicosia S, Dupont E, Greenberg H, Stowell N, White L, Patel J, Furman B, Cantor A, Hakam A, Ahmad N, Diaz N, King J. Accuracy of intraoperative imprint cytology for sentinel lymph node evaluation in the treatment of breast carcinoma. Cancer. 2005 Feb;105(1):13-20. Pubmedid: 15605359.
  • Diaz N, Vrcel V, Centeno B, Muro-Cacho C. Modes of benign mechanical transport of breast epithelial cells to axillary lymph nodes. Adv Anat Pathol. 2005 Jan;12(1):7-9. Pubmedid: 15614159.
  • Weinberg ES, Dickson D, White L, Ahmad N, Patel J, Hakam A, Nicosia S, Dupont E, Furman B, Centeno B, Cox C. Cytokeratin staining for intraoperative evaluation of sentinel lymph nodes in patients with invasive lobular carcinoma. Am J Surg. 2004 Oct;188(4):419-422. Pubmedid: 15474439.
  • Pirog E, Erroll M, Harigopal M, Centeno B. Comparison of human papillomavirus DNA prevalence in atypical squamous cells of undetermined significance subcategories as defined by the original Bethesda 1991 and the new Bethesda 2001 Systems. Arch Pathol Lab Med. 2004 May;128(5):527-532. Pubmedid: 15086283.
  • Weinberg E, Cox C, Dupont E, White L, Ebert M, Greenberg H, Diaz N, Vercel V, Centeno B, Cantor A, Nicosia S. Local recurrence in lumpectomy patients after imprint cytology margin evaluation. Am J Surg. 2004;188(4):349-354. Pubmedid: 15474425.
  • Brugge W, Lewandrowski K, Lee-Lewandrowski E, Centeno B, Szydlo T, ReganS, del Castillo C, Warshaw A. Diagnosis of pancreatic cystic neoplasms: a report of the cooperative pancreatic cyst study. Gastroenterology. 2004;126(5):1330-1336. Pubmedid: 15131794.
  • Diaz N, Cox C, Ebert M, Clark J, Vrcel V, Stowell N, Sharma A, Jakub J, Cantor A, Centeno B, Dupont E, Muro-Cacho C, Nicosia S. Benign Mechanical Transport of Breast Epithelial Cells to Sentinel Lymph Nodes. Am J Surg Pathol. 2004;28(12):1641-1645. Pubmedid: 15577685.
  • Mallery JS, Centeno BA, Hahn PF, Chang Y, Warshaw AL, Brugge WR. Pancreatic tissue sampling guided by EUS, CT/US, and surgery: a comparison of sensitivity and specificity. Gastrointest Endosc. 2002 Aug;56(2):218-224. Pubmedid: 12145600.
  • Centeno B. Role of cytology in the diagnosis of cystic and intradcutal papillary mucinous neoplasms. Gastrointest Endosc Clin N Am. 2002;12(4):697-708. Pubmedid: 12607780.
  • Rocha C, Centeno B. Update on pancreatic cancer. Curr Opin Oncol. 2002;14(4):424-430. Pubmedid: 12130928.
  • Husain K, Centeno BA, Chen DT, Hingorani S, Sebti SM, Malafa MP. Vitamin E δ-tocotrienol prolongs survival in the LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) transgenic mouse model of pancreatic cancer. Cancer Prev Res (Phila). 2013 Oct;6(10):1074-1083. Pubmedid: 23963802. Pmcid: PMC4165552.
  • Husain K, Centeno BA, Chen DT, Fulp WJ, Perez M, Zhang Lee G, Luetteke N, Hingorani SR, Sebti SM, Malafa MP. Prolonged survival and delayed progression of pancreatic intraepithelial neoplasia in LSL-KrasG12D/+;Pdx-1-Cre mice by vitamin E δ-tocotrienol. Carcinogenesis. 2013 Apr;34(4):858-863. Pubmedid: 23302291. Pmcid: PMC3616675.
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