Ariosto S. Silva, PhD

Where You Are:
Ariosto S. Silva, PhD

Assistant Member

Office  (813) 745-8205

Education And Training
  • Postdoctoral Fellow, Moffitt Cancer Center, 2010
  • PhD, Universidade Estadual Campinas- Unicamp, Brazil, 2008 - Genetics and Molecular Biology
  • BS, Tecnologico de Aeronautica - ITA, Brazil, 2000 - Computer Engineering

Evolution of tumor invasiveness and adaptive tumor microenvironment particularly in multiple myeloma; cancer metabolism

  • Tavares J, Silva I, Silva AS, Infante da Càmara M, Mendes J. Best impression materials in oral rehabilitation-study protolocol. Bull Group Int Rech Sci Stomatol Odontol. 2014 Dec;51(2):e09. Pubmedid: 25460785.
  • Petersen PA, Silva AS, Gonçalves MB, Lapolli AL, Ferreira AM, Carbonari AW, Petrilli HM. Cd hyperfine interactions in DNA bases and DNA of mouse strains infected with Trypanosoma cruzi investigated by perturbed angular correlation spectroscopy and ab initio calculations. Biochemistry-Us. 2014 Jun;53(21):3446-3456. Pubmedid: 24801145.
  • Khin ZP, Ribeiro ML, Jacobson T, Hazlehurst L, Perez L, Baz R, Shain K, Silva AS. A preclinical assay for chemosensitivity in multiple myeloma. Cancer Res. 2014 Jan;74(1):56-67. Pubmedid: 24310398. Pmcid: PMC3915502.
  • Carvalho MG, Tsuneto LT, Moita Neto JM, Sousa LC, Sales Filho HL, Macêdo MB, Barroso JR, Pereira EM, Araújo AS, Silva AS, Monte SJ. HLA-A, HLA-B and HLA-DRB1 haplotype frequencies in Piauí's volunteer bone marrow donors enrolled at the Brazilian registry. Hum Immunol. 2013 Dec;74(12):1598-1602. Pubmedid: 23994585.
  • Tafreshi NK, Silva A, Estrella VC, McCardle TW, Chen T, Jeune-Smith Y, Lloyd MC, Enkemann SA, Smalley KS, Sondak VK, Vagner J, Morse DL. In vivo and in silico pharmacokinetics and biodistribution of a melanocortin receptor 1 targeted agent in preclinical models of melanoma. Mol Pharm. 2013 Aug;10(8):3175-3185. Pubmedid: 23763620. Pmcid: PMC3785103.
  • Silva AS, Kam Y, Khin ZP, Minton SE, Gillies RJ, Gatenby RA. Evolutionary approaches to prolong progression-free survival in breast cancer. Cancer Res. 2012 Dec;72(24):6362-6370. Pubmedid: 23066036. Pmcid: PMC3525750.
  • Ribeiro MdLC, Silva AS, Bailey KM, Kumar NB, Sellers TA, Gatenby RA, Arig IH, Gillies RJ. Buffer therapy for cancer. J Nutr Food Sci. 2012 Jan;1-7.
  • Silva AS, Gatenby RA. Adaptation to survival in germinal center is the initial step in onset of indolent stage of multiple myeloma. Mol Pharm. 2011 Dec;8(6):2012-2020. Pubmedid: 21958215. Pmcid: PMC3437606.
  • Lee HO, Silva AS, Concilio S, Li YS, Slifker M, Gatenby RA, Cheng JD. Evolution of tumor invasiveness: the adaptive tumor microenvironment landscape model. Cancer Res. 2011 Oct;71(20):6327-6337. Pubmedid: 21859828. Pmcid: PMC3197231.
  • Silva A, Anderson AR, Gatenby R. A multiscale model of the bone marrow and hematopoiesis. Math Biosci Eng. 2011 Apr;8(2):643-658. Pubmedid: 21631151. Pmcid: PMC3754791.
  • Assumpção JG, Ganazza MA, de Araújo M, Silva AS, Scrideli CA, Brandalise SR, Yunes JA. Detection of clonal immunoglobulin and T-cell receptor gene rearrangements in childhood acute lymphoblastic leukemia using a low-cost PCR strategy. Pediatr Blood Cancer. 2010 Dec;55(7):1278-1286. Pubmedid: 20730889.
  • Silva AS, Gatenby RA. A theoretical quantitative model for evolution of cancer chemotherapy resistance. Biol Direct. 2010 Jul;5:25. Pubmedid: 20406443. Pmcid: PMC2868834.
  • Silva AS, Gatenby RA, Gillies RJ, Yunes JA. A quantitative theoretical model for the development of malignancy in ductal carcinoma in situ. J Theor Biol. 2010 Feb;262(4):601-613. Pubmedid: 19887072.
  • Gatenby RA, Silva AS, Gillies RJ, Frieden BR. Adaptive therapy. Cancer Res. 2009 Jun;69(11):4894-4903. Pubmedid: 19487300. Pmcid: PMC3728826.
  • Silva AS, Yunes JA, Gillies RJ, Gatenby RA. The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion. Cancer Res. 2009 May;69(6):2677-2684. Pubmedid: 19276380. Pmcid: PMC3718046.
  • Silva AS, Yunes JA. Conservation of glycolytic oscillations in Saccharomyces cerevisiae and human pancreatic beta-cells: a study of metabolic robustness. Genet Mol Res. 2007 Apr;5(3):525-535. Pubmedid: 17117368.
  • Rodrigues AS, Matos CB, Silva F, Fonseca I, Nogueira C, Santos J, Silva AS, Cabrita A. Long-term peritoneal dialysis experience in Portugal. Int J Artif Organs. 2006 Dec;29(12):1109-1116. Pubmedid: 17219350.
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