Richard C. Karl, MD

Where You Are:

Richard C. Karl, MD


For Consultation Requests or Referrals: (813) 745-8459


          •  Surgery

          •  Washington University School of Medicine - Pharmacology

          •  Washington University School of Medicine - Surgery

          •  Cornell University Medical College - MD

  • Shridhar R, Freilich J, Hoffe SE, Almhanna K, Fulp WJ, Yue B, Karl RC, Meredith K. Single-institution retrospective comparison of preoperative versus definitive chemoradiotherapy for adenocarcinoma of the esophagus. Ann Surg Oncol. 2014 Nov;21(12):3744-3750. Pubmedid: 24854492.

  • Pimiento JM, Weber J, Hoffe SE, Shridhar R, Almhanna K, Vignesh S, Karl RC, Meredith KL. Outcomes associated with surgery for T4 esophageal cancer. Ann Surg Oncol. 2013 Aug;20(8):2706-2712. Pubmedid: 23504118.

  • Wong J, Weber J, Almhanna K, Hoffe S, Shridhar R, Karl R, Meredith KL. Extent of lymphadenectomy does not predict survival in patients treated with primary esophagectomy. J Gastrointest Surg. 2013 Jul;17(9):1562-1569. Pubmedid: 23818125.

  • Shridhar R, Weber J, Hoffe SE, Almhanna K, Karl R, Meredith K. Adjuvant Radiation Therapy and Lymphadenectomy in Esophageal Cancer: A SEER Database Analysis. J Gastrointest Surg. 2013 Jun;17(8):1339-1345. Pubmedid: 23749498.

  • Melis M, Weber J, Shridhar R, Hoffe S, Almhanna K, Karl RC, Meredith KL. Body mass index and perioperative complications after oesophagectomy for adenocarcinoma: a systematic database review. BMJ Open. 2013 May;3(5). Pubmedid: 23645908. Pmcid: PMC3646172.

  • Hernandez JM, Dimou F, Weber J, Almhanna K, Hoffe S, Shridhar R, Karl R, Meredith K. Defining the Learning Curve for Robotic-assisted Esophagogastrectomy. J Gastrointest Surg. 2013 May;17(8):1346-1351. Pubmedid: 23690208.

  • Wong JY, Shridhar R, Almhanna K, Hoffe SE, Karl RC, Meredith KL. The impact of body mass index on esophageal cancer. Cancer Control. 2013 Apr;20(2):138-143. Pubmedid: 23571704.

  • Shridhar R, Hoffe SE, Almhanna K, Weber JM, Chuong MD, Karl RC, Meredith K. Lymph node harvest in esophageal cancer after neoadjuvant chemoradiotherapy. Ann Surg Oncol. 2013 Apr;20(9):3038-3043. Pubmedid: 23625142.

  • Yamamoto M, Weber JM, Karl RC, Meredith KL. Minimally invasive surgery for esophageal cancer: review of the literature and institutional experience. Cancer Control. 2013 Apr;20(2):130-137. Pubmedid: 23571703.

  • de la Fuente SG, Weber J, Hoffe SE, Shridhar R, Karl R, Meredith KL. Initial experience from a large referral center with robotic-assisted Ivor Lewis esophagogastrectomy for oncologic purposes. Surg Endosc. 2013 Apr;27(9):3339-3347. Pubmedid: 23549761.

  • Shridhar R, Hayman T, Hoffe SE, Weber J, Almhanna K, Chuong M, Karl RC, Meredith KL. Body mass index and survival in esophageal adenocarcinoma treated with chemoradiotherapy followed by esophagectomy. J Gastrointest Surg. 2012 Jul;16(7):1296-1302. Pubmedid: 22399271.

  • Dittrick GW, Weber JM, Shridhar R, Hoffe S, Melis M, Almhanna K, Barthel J, McLoughlin J, Karl RC, Meredith KL. Pathologic Nonresponders after Neoadjuvant Chemoradiation for Esophageal Cancer Demonstrate no Survival Benefit Compared with Patients Treated with Primary Esophagectomy. Ann Surg Oncol. 2012 May;19(5):1678-1684. Pubmedid: 22045465.

  • Karl R, Karl MC. Adverse events: root causes and latent factors. Surg Clin North Am. 2012 Feb;92(1):89-100. Pubmedid: 22269263.

  • Melis M, Weber JM, McLoughlin JM, Siegel EM, Hoffe S, Shridhar R, Turaga KK, Dittrick G, Dean EM, Karl RC, Meredith KL. An elevated body mass index does not reduce survival after esophagectomy for cancer. Ann Surg Oncol. 2011 Mar;18(3):824-831. Pubmedid: 20865331.

  • Melis M, Karl RC, Wong SL, Brennan MF, Matthews JB, Roggin KK. Evidence-based surgical practice in academic medical centers: consistently anecdotal?. J Gastrointest Surg. 2010 May;14(5):904-909. Pubmedid: 20213210.

  • Meredith KL, Weber JM, Turaga KK, Siegel EM, McLoughlin J, Hoffe S, Marcovalerio M, Shah N, Kelley S, Karl R. Pathologic response after neoadjuvant therapy is the major determinant of survival in patients with esophageal cancer. Ann Surg Oncol. 2010 Apr;17(4):1159-1167. Pubmedid: 20140529.

  • Karl R. Briefings, checklists, geese, and surgical safety. Ann Surg Oncol. 2010 Jan;17(1):8-11. Pubmedid: 19902307.

  • Melis M, McLoughlin JM, Dean EM, Siegel EM, Weber JM, Shah N, Kelley ST, Karl RC. Correlations between neoadjuvant treatment, anemia, and perioperative complications in patients undergoing esophagectomy for cancer. J Surg Res. 2009 May;153(1):114-120. Pubmedid: 19201421.

  • Karl R. Aviation. J Gastrointest Surg. 2009 Apr;13(1):6-8. Pubmedid: 18972171.

  • Kuruba R, Jawad M, Karl RC, Murr MM. Technique of resection of esophageal adenocarcinoma after Roux-en-Y gastric bypass and literature review of esophagogastric tumors after bariatric procedures. Surg Obes Relat Dis. 2009 Mar;5(5):576-581. Pubmedid: 19640802.

  • Helm J, Centeno B, Coppola D, Druta M, Park J, Chen D, Hodul P, Kvols LK, Yeatman T, Carey L, Karl R, Malafa M. Outcomes following resection of pancreatic adenocarcinoma: 20-year experience at a single institution. Cancer Control. 2008 Oct;15(4):288-294. Pubmedid: 18813196.

  • McLoughlin J, Melis M, Siegel E, Dean E, Weber J, Chern J, Elliott M, Kelley S, Karl R. Are patients with esophageal cancer who become PET negative after neoadjuvantchemoradiation free of cancer. J Am Coll Surg. 2008 May;206(5):879-886. Pubmedid: 18471715.

  • Goldin SB, Wahi MM, Farooq OS, Borgman HA, Carpenter HL, Wiegand LR, Nixon LL, Paidas C, Rosemurgy AS, Karl RC. Student quality-of-life declines during third year surgical clerkship. J Surg Res. 2007 Nov;143(1):151-157. Pubmedid: 17950086.

  • Newman M, Misiuta I, Willing A, Zigova T, Karl R, Borlongan C, Sanberg PR. Tumorigenicity issues of embryonic carcinoma-derived stem cells: relevance to surgical trials using NT2 and hNT neural cells. Stem Cells Dev. 2005 Feb;14(1):29-43. Pubmedid: 15725742.

  • Kelley S, Bloomston M, Serafini F, Carey L, Karl R, Zervos E, Goldin S, Rosemurgy P, Rosemurgy A. Cholangiocarcinoma: advocate an aggressive operative approach with adjuvant chemotherapy. Am Surg. 2004 Sep;70(9):743-748. Pubmedid: 15481288.

  • Hakam A, Fang Q, Karl R, Coppola D. Coexpression of IGF-1R and c-Src proteins in human pancreatic ductal adenocarcinoma. Digest Dis Sci. 2003 Oct;48(10):1972-1978. Pubmedid: 14627343.

  • Iravani S, Zhang HQ, Yuan ZQ, Cheng JQ, Karl RC, Jove R, Coppola D. Modification of insulin-like growth factor 1 receptor, c-Src, and Bcl-XL protein expression during the progression of Barrett's neoplasia. Hum Pathol. 2003 Oct;34(10):975-982. Pubmedid: 14608530.

  • Naidu K, Karl R, Naidu K, Coppola D. Antiproliferative and proapoptotic effect of ascorbyl stearate in human pancreatic cancer cells: association with decreased expression of insulin-like growth factor 1 receptor. Digest Dis Sci. 2003 Jan;48(1):230-237. Pubmedid: 12645815.

  • Marcet JE, Karl RC. Local excision of rectal tumors. Adv Surg. 2002;36:259-274. Pubmedid: 12465554.

  • Dessureault S, Coppola D, Weitzner M, Powers P, Karl R. Barrett's esophagus and squamous cell carcinoma in a patient with psychogenic vomiting. Int J Gastrointest Cancer. 2002;32(1):57-61. Pubmedid: 12630772.

  • Kim C, Yeatman T, Coppola D, Trotti A, Williams B, Barthel J, Dinwoodie W, Karl R, Marcet J. Local excision of T2 and T3 rectal cancers after downstaging chemoradiation. Ann Surg. 2001 Sep;234(3):352-358. Pubmedid: 11524588. Pmcid: PMC1422026.

  • Kocab M, Coppola D, Hiotis S, Karl R, Barthel J. Captopril-associated cholestasis complicating the management of pancreatic cancer. Surg Endosc. 2000 Jul;14(7):681. Pubmedid: 11265073.

  • Karl R, Schreiber R, Boulware D, Baker S, Coppola D. Factors affecting morbidity, mortality, and survival in patients undergoing Ivor Lewis esophagogastrectomy. Ann Surg. 2000 May;231(5):635-643. Pubmedid: 10767784. Pmcid: PMC1421050.

  • Karl R. Managing esophageal cancer. Cancer Control. 1999;6(1):3-4. Pubmedid: 10758530.

  • Teng S, Karl R. Surgical approaches to esophageal cancer. Cancer Control. 1999;6(1):36-42. Pubmedid: 10758533.

  • Hyacinthe M, Jaroszeski M, Dang V, Coppola D, Karl R, Gilbert R, Heller R. Electrically enhanced drug delivery for the treatment of soft tissue sarcoma. Cancer. 1999;85:409-417. Pubmedid: 10023709.

  • Hakam A, Yeatman T, Lu L, Mora L, Marcet J, Nicosia S, Karl R, Coppola D. Expression of insulin-like growth factor-1 receptor in human colorectal cancer. Hum Pathol. 1999;30(10):1128-1133. Pubmedid: 10534157.

  • Coppola D, Schreiber R, Mora L, Dalton W, Karl R. Significance of FAS and RB protein expression during the progression of Barrett's metaplasia to adenocarcinoma. Ann Surg. 1999;6(3):298-304. Pubmedid: 10340890.

  • Coppola D, Karl R. Barrett's esophagus and Barrett's associated neoplasia: etiology and pathologic features. Cancer Control. 1999;6(1):21-27. Pubmedid: 10758531.

  • Irby R, Mao W, Coppola D, Kang J, Trudeau W, Loubeau J, Karl R, Fujita D, Jove R, Yeatman T. Identification of an activating c-Src mutation with transforming and metastatic properties in human colon cancer. Nat Genet. 1999;21(2):187-190. Pubmedid: 9988270.

  • Iravani S, Mao W, Fu L, Karl R, Yeatman T, Jove R, Coppola D. Elevated c-Src protein expression is an early event in colonic neoplasia. Lab Invest. 1998 Mar;78(3):365-371. Pubmedid: 9520949 .

  • Coppola D, Lu L, Fruehauf J, Kyshtoobayeva A, Karl R, Nocosia S, Yeatman T. Analysis of p53, p21WAF1 and TFG-beta1 in human ductal adenocarcinoma of the pancreas: TFG-beta1 protein. Am J Clin Pathol. 1998;110(1):16-23. Pubmedid: 9661918.

  • Iravani S, Mao W, Fu I, Jove R, Yeatman T, Karl R, Coppola D. Elevated c-Src protein expression is an early event in colonic neoplasia. Lab Invest. 1998;78(3):365-371. Pubmedid: 9520949.

  • Coppola D, Hyacinthe M, Fu L, Cantor A, Karl R, Marcet J, Cooper D, Nicosia S, Cooper H. CD44V6 expression in human colorectal carcinoma. Hum Pathol. 1998;29(6):627-635. Pubmedid: 9635685.

  • Hyacinthe M, Karl R, Coppola D, Goodgene T, Redwood W, Goldenfarb P, Ohiri N, Marcet J. Squamous-cell carcinoma of the pelvis in a giant candyloma accumination: use of neoadjuvant chemoradiation and surgical resection. Dis Colon Rectum. 1998;41:1450-1453. Pubmedid: 9823814.

  • Yeatman T, Mao W, Karl R. Biliary glycoprotein is overexpressed in liVer-metastatic human colon cancer cells. J Gastro Surg. 1997;1(3):292-298. Pubmedid: 9834361.

  • Coppola D, Karl R. Pathology of early colonic neoplasia: clinical and pathologic features of precursor lesions and minimal carcinomas. Cancer Control. 1997;4(2):60-66. Pubmedid: 10763014.

  • Karl R, Choi J, Yeatman T, Clark R. Role of computed tomographic arterial portography (CTAP) and intraoperative ultrasound (IOUS) in the evaluation of patients for resectability of hepatic lesions. J Gastro Surg. 1997;1(2):152-158. Pubmedid: 9834342.

  • Coppola D, Karl R. Brunner's Gland Hamartoma: Is It Just a Morphologic Curiosity. Cancer Control. 1997;4(4):359-363. Pubmedid: 10763043.

  • Mao W, Yeatman T, Karl R, Jove R. c-Src activation by epidermal growth factor through receptor family kinases may potentiate human colon cancer liver metastasis. Surg Forum. 1996;67:507-510.

  • Foster J, Greene J, Sandin R, Sinnott J, Hitchock C, Spoto V, Karl R, Vincent A. Bowel perforation in patients with AIDS: two case reports and a review of the literature. Infect Med. 1996;4:294-297.

  • Yeatman T, Duan C, Mao W, Karl R, Djeu J. Augmentation of carcinoembryonic antigen release from intact, viable tumor cells by a factor in human serum. Ann Surg Oncol. 1995 Jul;2(4):336-342. Pubmedid: 7552624.

  • Yeatman T, Karl R. Molecular basis for chemoprevention of colorectal carcinogenesis. J Fla Med Assoc. 1995;82(5):360-363. Pubmedid: 7602310.

  • Karl R, Smith S, Fabri P. Validity of major cancer operations in elderly patients. Ann Surg Oncol. 1995;2(2):107-113. Pubmedid: 7728563.

  • Yeatman T, Mao W, Karl R, Djeu J. Phospholipase C-gamma is present on the surface of human colorectal cancer cells. Biochem Biophys Res Commun. 1994;201(2):1043-1049.

  • Balducci L, Cox C, Greenberg H, Lyman G, Miguel R, Karl R, Fabri P. Management of cancer in the older aged person. Cancer Control. 1994;1(2):132-137.

  • Yeatman T, Mao W, Karl R, Djeu J. Phospholiase C-gamma is present on the surface of human colerectal cancer cells. Biochem Biophys Res Commun. 1994;201(2):1043-1049.

  • Albrink M, McAllister E, Rosemurgy II A, Karl R, Carey L. Laparoscopic management of cystic disease of the liver. Am Surg. 1994;60(4):262-266.

  • Karl RC, Morse SS, Halpert RD, Clark RA. Preoperative evaluation of patients for liver resection. Appropriate CT imaging. Ann Surg. 1993 Mar;217(3):226-232. Pubmedid: 8452400. Pmcid: PMC1242773.

  • O'Kelly K, Helal M, Norman Jr. J, Karl R, Sanford E. Urologic aspects of hemicorpectomy. Br J Urol. 1993;72:915-917.

  • Stankard CE, Cruse C, Wells K, Karl R. Chronic pressure ulcer carcinomas. Ann Plast Surg. 1993;30(3):274-277.

  • Karl R, Carey L. Impact of staging on treatment of pancreatic and ampullary cancer. Endoscopy. 1993;25:69-74.

  • Karl R, Morse S, Halpert R, Clark R. Pre-operative evaluation of patients for liver resection: appropriate CT imaging. Ann Surg. 1993;217(3):226-232.

  • Feldman E, Karl R. Diagnosis and treatment of Ogilvie's syndrome after lumbar spinal surgery. J Neurosurg. 1992;76:1012-1016.

  • Stankard C, Karl R. The treatment of isolated metastases from renal cell carcinoma: a surgical review. Am J Gastroenterol. 1992;87:1658-1660.

  • Shepard KV, Levin B, Karl RC, Faintuch J, DuBrow RA, Hagle M, Cooper RM, Beschorner J, Stablein D. Therapy for metastatic colorectal cancer with hepatic artery infusion chemotherapy using a subcutaneous implanted pump. J Clin Oncol. 1985 Feb;3(2):161-169. Pubmedid: 3155793.

  • Balducci L, Cox C, Greenberg H, Lyman G, Miguel R, Karl R, Fabri P. Management of cancer in the older person. In: Balducci L, Lyman G, Erschler W, et al, eds. Comprehensive Geriatric Oncology. 2 ed. London. Harwood Academic Publishers; 1998;363-368.

  • Karl R, Yeatman T. Molecular screening and prevention of colon cancer. In: Reintgen D, Clark R, eds. Cancer Screening. St. Louis. Mosby Yearbook, Inc.; 1996;221-238.

  • Karl R, Carey L. Adenoma and adenocarcinoma of the ampulla of vater: diagnosis and staging. In: Sarr M, ed. The pancreas. Blackwell Science Ltd.; 1998;1316-1323.

  • Goldin SB, Osborne D, Paidas C, Iannello J, Gilbert-Barness E, Karl R, Wilsey MJ. Inflammatory myofibroblastic tumor of the midesophagus. Fetal Pediatr Pathol. 2007 Sept;26(5-6):243-254. Pubmedid: 18363157.

  • Kelley S, Coppola D, Karl R. Neoadjuvant chemoradiotherapy is not associated with a higher complication rate vs. surgery alone in patients undergoing esophagectomy. J Gastrointest Surg. 8(3):227-231. Pubmedid: 15019913.

  • Balducci L, Cox C, Greenberg H, Lyman G, Miguel R, Karl R, Fabri P. Management of cancer in the older person. In: Complete geriatric oncology. London. Harwood Academic Publishers; 1999;363-368.

  • Karl RC. Transplantation of islets of Langerhans. Arch Pathol. 1975 Aug;99(8):401-402. Pubmedid: 125078.

Dr. Richard Karl was the founding medical director of Moffitt Cancer Center and currently is a surgical oncologist and senior member of Moffitt Cancer Center’s Department of Gastrointestinal Oncology. He also serves as Moffitt’s physician safety officer.

Dr. Karl is the chairman emeritus and the Richard G. Connar professor of surgery at the University of South Florida’s College of Medicine. He serves as a member of the USF President’s advisory Group, USF Physician’s Group Executive Management Committee and other leadership positions.

A graduate of Cornell University Medical College, Dr. Karl completed a residency in surgery at Washington University School of Medicine in St. Louis, MO., where he was chief resident his last year.  

Before coming to Tampa, Dr. Karl was an associate professor of surgery at the University of Chicago.  

Dr. Karl has published nearly 80 papers in peer-reviewed journals and numerous book chapters.  He is a member of many professional societies, including the American Association for Cancer Research, the American Hepato-Pancreato-Biliary Association, Society of Surgical Chairman and the Society of Surgical Oncology. In addition, he is a governor-at large for the American College of Surgeons and a member of the program directors committee for the Society of Surgical Oncology.

 His clinical and research interests include gastrointestinal malignancies with particular interest in hepatic, biliary tract and esophageal cancer.



TOOLS:   Font Size small font resizer separator font resizer separator big font resizer
 |  Site Map  |  Privacy Policy  |  Terms and Conditions