Lodovico Balducci, MD

Where You Are:

Lodovico Balducci, MD

Medical Oncology

For Consultation Requests or Referrals: (813) 745-8658

 
 

BOARD CERTIFICATION:
          •  Hematology
          •  Medical Oncology

FELLOWSHIP:
          •  University of Mississippi Medical Center - Hematology/Oncology
          •  A. Gemelli General Hospital, Roma, Italy - Medicine

RESIDENCY:
          •  University of Mississippi Medical Center - Medicine

MEDICAL SCHOOL:
          •  Catholic University, Roma, Italy - MD

  • Coppola D, Balducci L, Chen DT, Loboda A, Nebozhyn M, Staller A, Fulp WJ, Dalton W, Yeatman T, Brem S. Senescence-associated-gene signature identifies genes linked to age, prognosis, and progression of human gliomas. J Geriatr Oncol. 2014 Sep. Pubmedid: 25220188.

  • Droz JP, Aapro M, Balducci L, Boyle H, Van den Broeck T, Cathcart P, Dickinson L, Efstathiou E, Emberton M, Fitzpatrick JM, Heidenreich A, Hughes S, Joniau S, Kattan M, Mottet N, Oudard S, Payne H, Saad F, Sugihara T. Management of prostate cancer in older patients: updated recommendations of a working group of the International Society of Geriatric Oncology. Lancet Oncol. 2014 Aug;15(9):e404-e414. Pubmedid: 25079103.

  • Naeim A, Aapro M, Subbarao R, Balducci L. Supportive Care Considerations for Older Adults With Cancer. J Clin Oncol. 2014 Aug;32(24):2627-2634. Pubmedid: 25071112.

  • Balducci L. Human genome, environment and medical practice. Intern Emerg Med. 2014 Aug;9(5):609-610. Pubmedid: 24906656.

  • Popa MA, Wallace KJ, Brunello A, Extermann M, Balducci L. Potential drug interactions and chemotoxicity in older patients with cancer receiving chemotherapy. J Geriatr Oncol. 2014 Jul;5(3):307-314. Pubmedid: 24821377.

  • Balducci L. Studying cancer treatment in the elderly patient population. Cancer Control. 2014 Jul;21(3):215-220. Pubmedid: 24955705.

  • van de Water W, Bastiaannet E, Egan KM, de Craen AJ, Westendorp RG, Balducci L, van de Velde CJ, Liefers GJ, Extermann M. Management of primary metastatic breast cancer in elderly patients-An international comparison of oncogeriatric versus standard care. J Geriatr Oncol. 2014 Jul;5(3):252-259. Pubmedid: 24661770.

  • Brighi N, Balducci L, Biasco G. Cancer in the elderly: Is it time for palliative care in geriatric oncology?. J Geriatr Oncol. 2014 Apr;5(2):197-203. Pubmedid: 24560041.

  • Balducci L, Aapro M. Complicated and complex: Helping the older patient with cancer to exit the labyrinth. J Geriatr Oncol. 2014 Jan;5(1):116-118. Pubmedid: 24484725.

  • Balducci L, Dolan D. Chronic Myelogenous Leukemia (CML) in the elderly. Mediterr J Hematol Infect Dis. 2014;6(1):e2014037. Pubmedid: 24959334. Pmcid: PMC4063619.

  • Crawford J, Armitage J, Balducci L, Becker PS, Blayney DW, Cataland SR, Heaney ML, Hudock S, Kloth DD, Kuter DJ, Lyman GH, McMahon B, Rugo HS, Saad AA, Schwartzberg LS, Shayani S, Steensma DP, Talbott M, Vadhan-Raj S, Westervelt P, Westmoreland M, Dwyer M, Ho M. Myeloid growth factors. J Natl Compr Canc Ne. 2013 Oct;11(10):1266-1290. Pubmedid: 24142827.

  • Cesari M, Cerullo F, Zamboni V, Di Palma R, Scambia G, Balducci L, Antonelli Incalzi R, Vellas B, Gambassi G. Functional status and mortality in older women with gynecological cancer. J Gerontol A Biol Sci Med Sci. 2013 Sep;68(9):1129-1133. Pubmedid: 23733856.

  • Vespa A, Ottaviani M, Rosselli M, Rossini S, Balducci L. Evaluation of intrapsychic processes, anxiety, and depression in postmenopausal women affected by breast cancer: a case-control study. Support Care Cancer. 2013 May;21(5):1281-1286. Pubmedid: 23262806.

  • Balducci L, Fossa SD. Rehabilitation of older cancer patients. Acta Oncol. 2013 Feb;52(2):233-238. Pubmedid: 23320771.

  • Balducci L. Frailty: a common pathway in aging and cancer. Interdiscip Top Gerontol. 2013;38:61-72. Pubmedid: 23503516.

  • Kaur P, Santillan AA, McGuire K, Turaga KK, Shamehdi C, Meade T, Ramos D, Mathias M, Parbhoo J, Davis M, Khakpour N, King J, Balducci L, Cox CE. The Surgical Treatment of Breast Cancer in the Elderly: A Single Institution Comparative Review of 5235 Patients with 1028 Patients ?70?years. Breast J. 2012 Sep;18(5):428-435. Pubmedid: 22957995.

  • Extermann M, Boler I, Reich RR, Lyman GH, Brown RH, DeFelice J, Levine RM, Lubiner ET, Reyes P, Schreiber FJ, Balducci L. Predicting the risk of chemotherapy toxicity in older patients: the Chemotherapy Risk Assessment Scale for High-Age Patients (CRASH) score. Cancer. 2012 Jul;118(13):3377-3386. Pubmedid: 22072065.

  • Hoffe S, Balducci L. Cancer and age: general considerations. Clin Geriatr Med. 2012 Feb;28(1):1-18. Pubmedid: 22326032.

  • Balducci L. Suffering and spirituality: analysis of living experiences. J Pain Symptom Manage. 2011 Sep;42(3):479-486. Pubmedid: 21854994.

  • Vespa A, Jacobsen PB, Spazzafumo L, Balducci L. Evaluation of intrapsychic factors, coping styles, and spirituality of patients affected by tumors. Psychooncology. 2011 Jan;20(1):5-11. Pubmedid: 20336646.

  • Shayne M, Balducci L. Hematopoietic growth factors in older cancer patients. Cancer Treat Res. 2011;157:383-402. Pubmedid: 21052967.

  • Kumar NB, Kazi A, Smith T, Crocker T, Yu D, Reich RR, Reddy K, Hastings S, Exterman M, Balducci L, Dalton K, Bepler G. Cancer cachexia: traditional therapies and novel molecular mechanism-based approaches to treatment. CURR TREAT OPTION ON. 2010 Dec;11(3-4):107-117. Pubmedid: 21128029. Pmcid: PMC3016925.

  • Balducci L. ESH-SIOG International Conference on Haematological Malignancies in the Elderly. Expert Rev Hematol. 2010 Dec;3(6):675-677. Pubmedid: 21091143.

  • Balducci L, Colloca G, Cesari M, Gambassi G. Assessment and treatment of elderly patients with cancer. Surg Oncol. 2010 Sep;19(3):117-123. Pubmedid: 20006489.

  • Droz JP, Balducci L, Bolla M, Emberton M, Fitzpatrick JM, Joniau S, Kattan MW, Monfardini S, Moul JW, Naeim A, van Poppel H, Saad F, Sternberg CN. Management of prostate cancer in older men: recommendations of a working group of the International Society of Geriatric Oncology. BJU Int. 2010 Aug;106(4):462-469. Pubmedid: 20346033. Pmcid: PMC3258484.

  • Balducci L. Bone complications of cancer treatment in the elderly. Oncology (Williston Park). 2010 Jul;24(8):741-747. Pubmedid: 20718254.

  • Silbermann M, Dweib Khleif A, Balducci L. Healing by cancer. J Clin Oncol. 2010 Mar;28(8):1436-1437. Pubmedid: 19917857.

  • Droz JP, Balducci L, Bolla M, Emberton M, Fitzpatrick JM, Joniau S, Kattan MW, Monfardini S, Moul JW, Naeim A, van Poppel H, Saad F, Sternberg CN. Background for the proposal of SIOG guidelines for the management of prostate cancer in senior adults. Crit Rev Oncol Hematol. 2010 Jan;73(1):68-91. Pubmedid: 19836968.

  • Balducci L. Treatment of cancer in the older aged person. Mediterr J Hematol Infect Dis. 2010;2(2):e2010029. Pubmedid: 21415975. Pmcid: PMC3033140.

  • Carreca I, Balducci L. Cancer chemotherapy in the older cancer patient. Urol Oncol. 2009 Nov;27(6):633-642. Pubmedid: 19879474.

  • Brunello A, Loaldi E, Balducci L. Dose adjustment and supportive care before and during treatment. Cancer Treat Rev. 2009 Oct;35(6):493-498. Pubmedid: 19493625.

  • Balducci L. Supportive care in elderly cancer patients. Curr Opin Oncol. 2009 Jul;21(4):310-317. Pubmedid: 19412099.

  • Balducci L. Treating elderly patients with hormone sensitive breast cancer: What do the data show. Cancer Treat Rev. 2009 Feb;35(1):47-56. Pubmedid: 18840391.

  • Balducci L. Pharmacology of antineoplastic medications in older cancer patients. Oncology (Williston Park). 2009 Jan;23(1):78-85. Pubmedid: 19283925.

  • Crawford J, Armitage J, Balducci L, Bennett C, Blayney DW, Cataland SR, Dale DC, Demetri GD, Erba HP, Foran J, Freifeld AG, Goemann M, Heaney ML, Htoy S, Hudock S, Kloth DD, Kuter DJ, Lyman GH, Michaud LB, Miyata SC, Tallman MS, Vadhan-Raj S, Westervelt P, Wong MK. Myeloid growth factors. J Natl Compr Canc Netw. 2009 Jan;7(1):64-83. Pubmedid: 19176207.

  • Ferrucci L, Balducci L. Anemia of aging: the role of chronic inflammation and cancer. Semin Hematol. 2008 Oct;45(4):242-249. Pubmedid: 18809094. Pmcid: PMC2645640.

  • Balducci L, Tam-McDevitt J, Hauser R, Simon J. Re: Cost of care for the elderly cancer patients in the United States. J Natl Cancer Inst. 2008 Oct;100(19):1413-1414. Pubmedid: 18812555.

  • Basche M, Bar?n AE, Eckhardt SG, Balducci L, Persky M, Levin A, Jackson N, Zeng C, Vranas P, Steiner JF. Barriers to enrollment of elderly adults in early-phase cancer clinical trials. J Oncol Pract. 2008 Jul;4(4):162-168. Pubmedid: 20856765.

  • Hurria A, Balducci L, Naeim A, Gross C, Mohile S, Klepin H, Tew W, Downey L, Gajra A, Owusu C, Sanati H, Suh T, Figlin R. Mentoring junior faculty in geriatric oncology: report from the Cancer and Aging Research Group. J Clin Oncol. 2008 Jul;26(19):3125-3127. Pubmedid: 18591553. Pmcid: PMC3622440.

  • Balducci L. Journal of Clinical Oncology: the next 25 years. J Clin Oncol. 2008 Apr;26(10):e4-e4. Pubmedid: 18375885.

  • Balducci L, Tam-McDevitt J, Hauser R, Simon J. Long overdue - phase II studies in older cancer patients: where does the FDAstand. J Clin Oncol. 2008 Mar;26(8):1387-1388. Pubmedid: 18323564.

  • Carlson RW, Moench S, Hurria A, Balducci L, Burstein HJ, Goldstein LJ, Gradishar WJ, Hughes KS, Jahanzeb M, Lichtman SM, Marks LB, McClure JS, McCormick B, Nabell LM, Pierce LJ, Smith ML, Topham NS, Traina TA, Ward JH, Winer EP. NCCN Task Force Report: breast cancer in the older woman. J Natl Compr Canc Netw. 2008;6 Suppl 4:S1-25. Pubmedid: 18597715.

  • Balducci L, Al-Halawani H, Charu V, Tam J, Shahin S, Dreiling L, Ershler WB. Elderly cancer patients receiving chemotherapy benefit from first-cycle pegfilgrastim. Oncologist. 2007 Dec;12(12):1416-1424. Pubmedid: 18165618.

  • Boccia R, Lillie T, Tomita D, Balducci L. The effectiveness of darbepoetin alfa administered every 3 weeks on hematologic outcomes and quality of life in older patients with chemotherapy-induced anemia. Oncologist. 2007 May;12(5):584-593. Pubmedid: 17522247.

  • Lichtman SM, Balducci L, Aapro M. Geriatric oncology: a field coming of age. J Clin Oncol. 2007 May;25(14):1821-1823. Pubmedid: 17488979.

  • Perkins EA, Small BJ, Balducci L, Extermann M, Robb C, Haley WE. Individual differences in well-being in older breast cancer survivors. Crit Rev Oncol Hematol. 2007 Apr;62(1):74-83. Pubmedid: 17240157. Pmcid: PMC1911161.

  • Kumar A, Soares H, Balducci L, Djulbegovic B. Treatment tolerance and efficacy in geriatric oncology: a systematic review of phase III randomized trials conducted by five National Cancer Institute-sponsored cooperative groups. J Clin Oncol. 2007 Apr;25(10):1272-1276. Pubmedid: 17401017.

  • Robb C, Haley W, Balducci L, Extermann M, Perkins E, Small B, Mortimer J. Impact of breast cancer survivorship on quality of life in older women. Crit Rev Oncol Hematol. 2007 Apr;62(1): 84-91. Pubmedid: 17188505.

  • Balducci L. An overlooked problem: anemia in the elderly patient with cancer. J Support Oncol. 2007 Mar;5(3):115-116. Pubmedid: 17410808.

  • Crawford J, Althaus B, Armitage J, Balducci L, Bennett C, Blayney D, Cataland S, Dale D, Demetri G, Erba H, Foran J, Freifeld A, Heaney M, HtoyS, Kloth D, Lyman G, Messersmith W, Michaud L, Miyata S, Robbins A, TallmanMS, Vadhan-Raj S, Westervelt P, Wong M. Myeloid growth factors guidelines. J Natl Compr Canc Netw. 2007 Feb;5(2):188-202. Pubmedid: 17335688.

  • Tam-McDevitt J, Balducci L, Hauser R, Gura D, Paraghamian A, Thomas H, Lichtman S. Has demand for clinical trial participants outpaced supply?. J Natl Cancer Inst. 2007 Jan;99(1):86-87. Pubmedid: 17202120.

  • Balducci L. Aging, frailty, and chemotherapy. Cancer Control. 2007 Jan;14(1):7-12. Pubmedid: 17242666.

  • Balducci L. Molecular insight in cancer treatment and prevention. Int J Biochem Cell Biol. 2007;39(7-8):1329-1336. Pubmedid: 17531523.

  • Balducci L. Management of chemotherapy-induced neutropenia in the older cancer patient. Oncology (Williston Park). 2006 Dec;20(14 Suppl 9):26-31. Pubmedid: 17370926.

  • Balducci L. Management of chemotherapy-induced neutropenia in the older cancer patient. Oncology (Williston Park). 2006 Dec;20(14):26-31.

  • Smith T, Khatcheressian J, Lyman G, Ozer H, Armitage J, Balducci L, Bennett C, Cantor S, Crawford J, Cross S, Demetri G, Desch C, Pizzo P, Schiffer C, Schwartzberg L, Somerfield M, Somlo G, Wade J, Wade J, Winn R, Wozniak A, Wolff A. 2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline. J Clin Oncol. 2006 Jul;24(19):3187-3205. Pubmedid: 16682719.

  • Balducci L. Transfusion independence in patients with myelodysplastic syndromes: impact on outcomes and quality of life. Cancer. 2006 May;106(10):2087-2094. Pubmedid: 16607649.

  • Balducci L, Ershler W, Krantz S. Anemia in the elderly-Clinical findings and impact on health. Crit Rev Oncol Hematol. 2006 May;58(2):156-165. Pubmedid: 16387511.

  • Balducci L. Management of cancer in the elderly. Oncology (Williston Park). 2006 Feb;20(2):135-143. Pubmedid: 16562648.

  • Balducci L. Prevention of cancer in the older person. Cancer J. 2005 Nov;11(6):442-448. Pubmedid: 16393478.

  • Balducci L. Squaring the circle: adjuvant chemotherapy for older women with breast cancer. J Gerontol A Biol Sci Med Sci. 2005 Oct;60(9):1135-1136. Pubmedid: 16183951.

  • Balducci L, Ershler W. Cancer and ageing: a nexus at several levels. Nat Rev Cancer. 2005 Aug;5(8):655-662. Pubmedid: 16056261.

  • Carreca I, Balducci L, Extermann M. Cancer in the older person. Cancer Treat Rev. 2005 Aug;31(5):380-402. Pubmedid: 15967582.

  • Balducci L. Supportive care of elderly patients with cancer. Support Cancer Ther. 2005 Jul;2(4):225-228. Pubmedid: 18628177.

  • Balducci L, Cohen H, Engstrom P, Ettinger D, Halter J, Gordon L, Kiel K, Kneier A, Lim D, Petersdorf S, Rosenthal R, Silliman R, Vose J, Walker M, Zachariah B. Senior adult oncology clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2005 Jul;3(4):572-590. Pubmedid: 16038647.

  • Mandelblatt JS, Schechter CB, Yabroff KR, Lawrence W, Dignam J, Extermann M, Fox S, Orosz G, Silliman R, Cullen J, Balducci L. Toward optimal screening strategies for older women. Costs, benefits, and harms of breast cancer screening by age, biology, and health status. J Gen Intern Med. 2005 Jun;20(6):487-496. Pubmedid: 15987322. Pmcid: PMC1490138.

  • Gridelli C, Aapro M, Ardizzoni A, Balducci L, De Marinis F, Kelly K, LeChevalier T, Manegold C, Perrone F, Rosell R, Shepherd F, De Petris L, Di MaioM, Langer C. Treatment of advanced non-small-cell lung cancer in the elderly: results of an international expert panel. J Clin Oncol. 2005 May;23(13):3125-3137. Pubmedid: 15860872.

  • Extermann M, Chen H, Booth-Jones M, Meyer J, Balducci L, Jacobsen P. Pilot testing of the computerized cognitive test Microcog in chemotherapy-treated older cancer patients. Crit Rev Oncol Hematol. 2005 May;54(2):137-143. Pubmedid: 15843096.

  • Balducci L. Epidemiology of cancer and aging. J Oncol Manag. 2005 Apr;14(2):47-50. Pubmedid: 16018199.

  • Balducci L. Cancer chemotherapy in elderly cancer patients. J Oncol Manag. 2005 Apr;14(2):35-38. Pubmedid: 16018197.

  • Balducci L, Aapro M. Epidemiology of cancer and aging. Cancer Treat Res. 2005;124:1-15. Pubmedid: 15839188.

  • Balducci L. Guidelines for the management of the older cancer patient. Cancer Treat Res. 2005;124:233-256. Pubmedid: 15839199.

  • Beghe C, Balducci L. Biological basis of cancer in the older person. Cancer Treat Res. 2005;124:189-221. Pubmedid: 15839197.

  • Balducci L, Hardy C, Lyman G. Hemopoiesis and aging. Cancer Treat Res. 2005;124:109-134. Pubmedid: 15839193.

  • Donovan KA, Jacobsen PB, Andrykowski MA, Winters EM, Balducci L, Malik U, Kenady D, McGrath P. Course of fatigue in women receiving chemotherapy and/or radiotherapy for early stage breast cancer. J Pain Symptom Manag. 2004 Oct;28(4):373-380. Pubmedid: 15471655. Pmcid: PMC2398710.

  • Extermann M, Meyer J, McGinnis M, Crocker T, Corcoran M, Yoder J, Haley W, Chen H, Boulware D, Balducci L. A comprehensive geriatric intervention detects multiple problems in older breast cancer patients. Crit Rev Oncol Hematol. 2004 Jan;49(1):69-75. Pubmedid: 14734156.

  • Kumar N, Allen K, Riccardi D, Bercu B, Cantor A, Minton S, Balducci L, Jacobsen P. Fatigue, weight gain, lethargy and amenorrhea in breast cancer patients on chemotherapy: is subclinical hypothyroidism the culprit?. Breast Cancer Res Treat. 2004 Jan;83(2):149-159. Pubmedid: 14997046.

  • Balducci L, Repetto L. Increased risk of myelotoxicity in elderly patients with non-Hodgkin lymphoma. Cancer. 2004;100(1):6-11. Pubmedid: 14692018.

  • Balducci L. Believing is seeing: a new parameter to study cancer prevention and cancer treatment in older individuals. Cancer. 2004;100(5):881-882. Pubmedid: 14983480.

  • Balducci L. Cost of cancer clinical trials in elderly patients. Expert Opin Pharmacother. 2004;5(3):505-511. Pubmedid: 15013919.

  • Biganzoli L, Aapro M, Balducci L, Crivellari D, Minisini A, Piccart M. Adjuvant therapy in elderly patients with breast cancer. Clin Breast Cancer. 2004;5(3):188-195. Pubmedid: 15335450.

  • Balducci L. Profile of Prof. Paul Calabresi. Oncologist. 2004;9(1):110-110. Pubmedid: 14755021.

  • Knight K, Wade S, Balducci L. Prevalence and outcomes of anemia in cancer: a systematic review of the literature. Am J Med. 2004;116:11S-26S. Pubmedid: 15050883.

  • Martoni A, Cucinotta D, Balducci L. Meeting report: Breast cancer in the older woman. Tumori. 2004;90(4):437-445. Pubmedid: 15510992.

  • Luciani A, Balducci L. Multiple primary malignancies. Semin Oncol. 2004;31(2):264-273. Pubmedid: 15112155.

  • Balducci L. Myelosuppression and its consequences in elderly patients with cancer. Oncology (Williston Park). 2003;17:27-32. Pubmedid: 14682116.

  • Chen H, Cantor A, Meyer J, Corcoran M, Grendys E, Cavanaugh D, AntonekS, Camarata A, Haley W, Balducci L, Extermann M. Can older cancer patients tolerate chemotherapy? A prospective pilot study. Cancer. 2003;97(4):1107-1114. Pubmedid: 12569613.

  • Balducci L. Management of cancer pain in geriatric patients. J Support Oncol. 2003;1(3):175-191. Pubmedid: 15334874.

  • Balducci L, Carreca I. Supportive care of the older cancer patient. Crit Rev Oncol Hematol. 2003;48:S65-S70. Pubmedid: 14563523.

  • Extermann M, Balducci L. Optimizing cancer care in the elderly: progress in geriatric oncology. Cancer Control. 2003;10(6):440-441. Pubmedid: 14652519.

  • Balducci L. Epidemiology of anemia in the elderly: information on diagnostic evaluation. J Am Geriatr Soc. 2003;51:2-9. Pubmedid: 12588565.

  • Lyman G, Kuderer N, Agboola O, Balducci L. Evidence-based use of colony-stimulating factors in elderly cancer patients. Cancer Control. 2003;10(6):487-499. Pubmedid: 14652525.

  • Balducci L. New paradigms for treating elderly patients with cancer: the comprehensive geriatric assessment and guidelines for supportive care. J Support Oncol. 2003;1(4):30-37. Pubmedid: 15346998.

  • Balducci L. Geriatric oncology. Crit Rev Oncol Hematol. 2003;46(3):211-220. Pubmedid: 12791420.

  • Respini D, Jacobsen P, Thors C, Tralongo P, Balducci L. The prevalence and correlates of fatigue in older cancer patients. Crit Rev Oncol Hematol. 2003;47(3):273-279. Pubmedid: 12962901.

  • Balducci L. Lung cancer in the elderly: so many patients, so little time. Ca Cancer J Clin. 2003;53:322-324. Pubmedid: 15224972.

  • Balducci L. The elderly patient with cancer: new approaches for improved outcomes. J Support Oncol. 2003;1(4):3-4. Pubmedid: 15346993.

  • Balducci L. Anemia, cancer, and aging. Cancer Control. 2003;10(6):478-486. Pubmedid: 14652524.

  • Repetto L, Carreca I, Maraninchi D, Aapro M, Calabresi P, Balducci L. Use of growth factors in the elderly patient with cancer: a report from the Second International Society for Geriatric Oncology (SIOG) 2001 meeting. Crit Rev Oncol Hematol. 2003;45(2):123-128. Pubmedid: 12604125.

  • Repetto L, Balducci L. A case for geriatric oncology. Lancet Oncol. 2002 May;3(5):289-297. Pubmedid: 12067806.

  • Patterson S, Balducci L, Meyer R. The Book of Job: a 2,500-year-old current guide to the practice of oncology: the nexus of medicine and spirituality. J Cancer Educ. 2002;17(4):237-240. Pubmedid: 12556063.

  • Patterson S, Balducci L, Pow-Sang J. Controversies surrounding androgen deprivation for prostate cancer. Cancer Control. 2002;9(4):315-325. Pubmedid: 12228757.

  • Balducci L, Carreca I. The role of myelopoietic growth factors in managing cancer in the elderly. Drugs. 2002;62:47-63. Pubmedid: 12479594.

  • Lyman G, Kuderer N, Balducci L. Cost-benefit analysis of granulocyte colony-stimulating factor in the management of elderly cancer patients. Curr Opin Hematol. 2002;9(3):207-214. Pubmedid: 11953666.

  • Balducci L. The clinical impact of cancer in the old-aged person. Tumori. 2002;88(1):S47-S48. Pubmedid: 11989923.

  • Balducci L, Beghe C. Prevention of cancer in the older person. Clin Geriatr Med. 2002;18(3):505-528. Pubmedid: 12424870.

  • Extermann M, Chen H, Cantor A, Corcoran M, Meyer J, Grendys E, CavanaughD, Antonek S, Camarata A, Haley W, Balducci L. Predictors of tolerance to chemotherapy in older cancer patients: a prospective pilot study. Eur J Cancer. 2002;38(11):1466-1473. Pubmedid: 12110492.

  • Overcash J, Extermann M, Parr J, Perry J, Balducci L. Validity and reliability of the FACT-G scale for use in the older person with cancer. Am J Clin Oncol. 2001;24(6):591-596. Pubmedid: 11801761.

  • Balducci L, Meyer R. Spirituality and medicine: a proposal. Cancer Control. 2001;8(4):368-376. Pubmedid: 11483891.

  • Balducci L, Hardy C, Lyman G. Hematopoietic growth factors in the older cancer patient. Curr Opin Hematol. 2001;8(3):170-187. Pubmedid: 11303151.

  • Balducci L. Cancer: an experiment education. Cancer Control. 2001;8(2):192-196. Pubmedid: 11326176.

  • Balducci L, Extermann M. A practical approach to the older patient with cancer: a review. Curr Probl Cancer. 2001;25(1):6-76. Pubmedid: 11261937.

  • Balducci L, Extermann M, Carreca I. Management of breast cancer in the older woman. Cancer Control. 2001;8(5):431-441. Pubmedid: 11579340.

  • Balducci L. The geriatric cancer patient: equal benefit from equal treatment. Cancer Control. 2001;8(2):1-25. Pubmedid: 11326165.

  • Balducci L, Beghe C. Cancer and age in the USA. Crit Rev Oncol Hematol. 2001;37(2):137-145. Pubmedid: 11166587.

  • Balducci L, Lyman G. Patients aged > or = 70 are at high risk for neutropenic infection and should receive hemopoietic growth factors when treated with moderately toxic chemotherapy. J Clin Oncol. 2001;19(5):1583-1585. Pubmedid: 11230505.

  • Balducci L, Extermann M. Management of the frail person with advanced cancer. Crit Rev Oncol Hematol. 2000;33(2):143-148. Pubmedid: 10737376.

  • Kimmick G, Balducci L. Breast cancer and aging. Clinical interactions. Hematol Oncol Clin North Am. 2000;14(1):213-234. Pubmedid: 10680079.

  • Zachariah B, Balducci L. Radiation therapy of the older patient. Hematol Oncol Clin North Am. 2000;14(1):131-167. Pubmedid: 10680076.

  • Remick S, Sedransk N, Haase R, Craffey M, Subramanian N, Dowlati A, Nazeer T, Ramnes C, Blanchard C, Martrianni D, Balducci L, Horton J, Ruckdeschel J. Oral combination chemotherapy in the management of AIDS-related lymphoproliferative malignancies. Drugs. 2000;58(3):99-107. Pubmedid: 10711848.

  • Balducci L, Stanta G. Cancer in the frail patient. A coming epidemic. Hematol Oncol Clin North Am. 2000;14(1):235-50,xi. Pubmedid: 10680080.

  • Balducci L, Beghe C. The application of the principles of geriatrics to the management of the older person with cancer. Crit Rev Oncol Hematol. 2000;35(3):147-154. Pubmedid: 10960797.

  • Balducci L. Inspiration from a forum arranged by students. J Cancer Educ. 2000;15(4):245-245. Pubmedid: 11199245.

  • Balducci L, Extermann M. Management of cancer in the older person: a practical approach. Oncologist. 2000;5(3):224-237. Pubmedid: 10884501.

  • Balducci L. Geriatric oncology: challenges for the new century. Eur J Cancer. 2000;36(14):1741-1754. Pubmedid: 10974621.

  • Balducci L. Evidence-based management of cancer in the elderly. Cancer Control. 2000;7(4):368-376. Pubmedid: 10895132.

  • Balducci L. Cancer in the elderly: tailoring treatment. Hosp Pract (Off Ed). 2000;35(3):73-80. Pubmedid: 10737241.

  • Mandelblatt J, Orosz G, Yabroff K, Extermann M, Lawrence W, Yi B, Satariano W, Bloom H, Fox S, Silliman R, Fahs M, Schecther C, Muenning P, Balducci L. Screening mammography in elderly women. Research on Breast Cancer in Older Women Consortium. Jama. 2000;283(24):3202-3203. Pubmedid: 10866863.

  • Balducci L, Yates J. General guidelines for the management of older patients with cancer. Oncology (Williston Park). 2000;14(11A):221-227. Pubmedid: 11195414.

  • Extermann M, Balducci L, Lyman G. What threshold for adjuvant therapy in older breast cancer patients?. J Clin Oncol. 2000;18(8):1709-1717. Pubmedid: 10764431.

  • Balducci L, Extermann M. Cancer and aging. An evolving panorama. Hematol Oncol Clin North Am. 2000;14(1):1-16. Pubmedid: 10680068.

  • Broeckel J, Jacobsen P, Balducci L, Horton J, Lyman G. Quality of life after adjuvant chemotherapy for breast cancer. Breast Cancer Res Treat. 2000;62(2):141-150. Pubmedid: 11016752.

  • Balducci L, Hardy C, Lyman G. Hemopoietic reserve in the older cancer patient: clinical and economic considerations. Cancer Control. 2000;7(6):539-547. Pubmedid: 11088062.

  • Balducci L, Corcoran M. Antineoplastic chemotherapy of the older cancer patient. Hematol Oncol Clin North Am. 2000;14(1):193-212. Pubmedid: 10680078.

  • Jacobsen PB, Hann DM, Azzarello LM, Horton J, Balducci L, Lyman GH. Fatigue in women receiving adjuvant chemotherapy for breast cancer: characteristics, course, and correlates. J Pain Symptom Manage. 1999 Oct;18(4):233-242. Pubmedid: 10534963.

  • Balducci L, Extermann M. Cancer in the elderly. Clin Geriatr Med. 1999;6(13):51-58. Pubmedid: noPMID.

  • Balducci L. Mangement of cancer in the older person. Clin Geriatr Med. 1999;7(5):89-97. Pubmedid: noPMID.

  • Balducci L, Beghe C. Pharmacology of chemotherapy in the older cancer patient. Cancer Control. 1999;6(5):466-470. Pubmedid: 10758578.

  • Balducci L, Hardy C. Aging, stress and anemia. Matur Med Canada. 1999;82-85. Pubmedid: noPMID.

  • Lyman G, Balducci L. Update on the economic analyses of the use of the colony-stimulating factors. Curr Opin Hematol. 1999;6(3):145-151. Pubmedid: 10226734.

  • Extermann M, Overcash J, Lyman G, Parr J, Balducci L. Comorbidity and functional status are independent in older cancer patients. J Clin Oncol. 1998;16(4):1582-1587. Pubmedid: 9552069.

  • Lyman G, Kuderer N, Balducci L. Economic impact of granulopoiesis stimulating agents on the management of febrile neutropenia. Curr Opin Oncol. 1998;10:291-298. Pubmedid: 9702395.

  • Lyman G, Kuderer N, Balducci L. Cancer care in the elderly: cost and quality of life considerations. Cancer Control. 1998;5:347-354. Pubmedid: 10761085.

  • Benson K, Agosti S, Lyman G, Pow-Sang J, Saba H, Balducci L. Estimated blood loss in group O as compared to non-group O radical prostatectomy. Hematology. 1998;3:257-261. Pubmedid: noPMID.

  • Lyman G, Kuderer N, Greene J, Balducci L. The economics of febrile neutropenia: implications for the use of colony-stimulating factors. Eur J Cancer. 1998;34(12):1857-1864. Pubmedid: 10023306.

  • Balducci L, Hardy C. Anemia of aging: a model of erythropoiesis in cancer patients. Cancer Control. 1998;5(2):17-21. Pubmedid: 10762462.

  • Broeckel J, Jacobsen P, Horton J, Balducci L, Lyman G. Characteristics and correlates of fatigue after adjuvant therapy for breast cancer. J Clin Oncol. 1998;16(5):1689-1696. Pubmedid: 9586880.

  • Balducci L, Extermann M. Difficulties in treating older patients with cancer. Oncology Pract. 1998;15-18. Pubmedid: noPMID.

  • Lyman G, Lyman S, Kuderer N, Balducci L, Reintgen D, Cox C. Menopausal status and breast cancer survival following recurrence. Matur Med Canada. 1998;1:29-31.

  • Balducci L, Phillips D. Breast cancer in older women Am Fam Physician. Am Fam Phys. 1998;58(5):1163-1172. Pubmedid: 9787281.

  • Balducci L. Issues in the management of haematologic malignancies. From the 26th Congress of the International Society of Haematology (ISH), Signapore, 25-29 August 1996. Oncology Forum. 1997;1(1):12-12. Pubmedid: noPMID.

  • Balducci L, Extermann M, Fentiman I, Monfardini S, Perrone F. Should adjuvant chemotherapy be used to treat breast cancer in elderly patients (> or = 70 years of age)?. Eur J Cancer. 1997;33:1720-1724. Pubmedid: 9470824.

  • Balducci L, Trotti, III A. Organ preservation: an effective and safe form of cancer treatment. Clin Geriatr Med. 1997;13(1):185-201. Pubmedid: 8995107.

  • Wells N, Balducci L. Geriatric Oncology Medical and Psychosocial Perspectives. Cancer Practice. 1997;5(2):87-91. Pubmedid: 9110644.

  • Balducci L, Extermann M. Cancer chemotherapy in the older person: what the medical oncologists needs to know. Cancer. 1997;80:1317-1322. Pubmedid: 9317185.

  • Zachariah B, Balducci L, Venkattaramanabalaji G, Casey L, Greenberg H, DelRegato J. Radiotherpay for cancer patients aged 80 and older: a study of effectiveness and side effects. Int J Radiat Oncol Biol Phys. 1997;39(5):1125-1129. Pubmedid: 9392554.

  • Lyman G, Kuderer N, Lyman S, Debus M, Minton S, Balducci L, Horton J, Reintgen D, Cox C. Menopausal status and the impact of early recurrence on breast cancer survival. Cancer Control. 1997;4(4):335-341. Pubmedid: 10763039.

  • Kimmick G, Fleming R, Muss H, Balducci L. Cancer chemotherapy in older adults: a tolerability perspective. Drugs Aging. 1997;10(1):34-49. Pubmedid: 9111706.

  • Balducci L, Lyman G. Cancer in the elderly: epidemiologic and clinical implications. Clin Geriatr Med. 1997;13:1-14. Pubmedid: 8995097.

  • Balducci L. Highlights of the third international conference in geriatric oncology held in Tampa, Florida, 13-15 November, 1996. Eur J Cancer. 1997;33(6):836-837. Pubmedid: noPMID.

  • Balducci L, Extermann M. Advances in cancer therapy for the older patient. Intern Med. 1997;18:79-92. Pubmedid: noPIMID.

  • Reintgen D, Joseph E, Lyman G, Yeatman T, Balducci L, Ku N, Berman C, Shons A, Wells K, Horton J, Greenberg H, Nicosia S, Clark R, Shivers S, Li W, Wang X, Cantor A, Cox C. The role of selective lymphadenectomy in breast cancer. Cancer Control. 1997;4(3):211-219. Pubmedid: 10763020.

  • Lyman G, Kuderer N, Balducci L. The decision to use colony stimulating factors in patients receiving cancer chemotherapy: quality of life adjustment. Proc Am Soc Clin Oncol. 1996;15:535-535.

  • Albertini J, Lyman G, Cox C, Yeatman T, Balducci L, Ku N, Shivers S, Berman C, Wells K, Rapaport D, Shons A, Horton J, Greenberg H, Nicosia S, Clark R, Cantor A, Reintgen D. Lymphatic mapping and sentinel node biopsy in the patient with breast cancer. Jama. 1996;276(22):1818-1822. Pubmedid: 8946902.

  • Lyman G, Kuderer N, Balducci L, Horton J. Thresholds for the use of recombinant human colony-stimulating factors (CSFs) based on revised cost estimates incorporating indirect medical, non-medical and intangible cost considerations. Blood. 1996;88:346a-346a.

  • Lyman G, Lyman S, Balducci L, Kuderer N, Reintgen D, Harris J, Cox C, Baekey P, Greenberg H, Horton J. Age and the risk of recurrence in women with breast cancer. Cancer Control. 1996;3:421-427. Pubmedid: 10764500.

  • Balducci L, Lyman G, Fabri P. Management of cancer in the aged. Compr Ther. 1996;22(2):88-93. Pubmedid: 8689868.

  • Extermann M, Balducci L, Lyman G. Optimal duration of adjuvant tamoxifen treatment in elderly breast cancer patients: influence of age, cormorbidites, and various effectiveness hypothesis on life-expectancy. Breast Dis. 1996;9:327-339.

  • Benson K, Balducci L, Milo K, Heckel L, Lyman G. Patient's attitudes regarding out-of-hospital blood transfusion. Transfusion. 1996;36:140-143. Pubmedid: 8614964.

  • Robinson B, Balducci L. Breast lump in an 85-year-old woman with dementia: a decision analysis. Am Geriatr Soc. 1995;155:171-175. Pubmedid: 7884120.

  • Casey L, Zachariah B, Balducci L. Radiotherapy of the oldest old cancer patients: a study of effectiveness and toxicity. J Am Geriatr Soc. 1995;43:1-3. Pubmedid: noPMID.

  • Lyman G, Balducci L. A cost analysis of hematopoietic colony-stimulating factors. Oncology. 1995;9:85-91. Pubmedid: 8608061.

  • Zachariah B, Zachariah S, Varghese R, Balducci L. Review: carcinomatous meningitis: clinical manifestations and management. Int J Clin Pharmacol Ther Toxicol. 1995;33(1):7-12. Pubmedid: 7711996.

  • Zachariah B, Casey L, Balducci L. Radiotherapy of the oldest old cancer patients: a study of effectiveness and toxicity. J Am Geriatr Soc. 1995;43:793-795. Pubmedid: 7602034.

  • Lyman GH, Balducci L. The effect of changing disease risk on clinical reasoning. J Gen Intern Med. 1994 Sep;9(9):488-495. Pubmedid: 7996291.

  • Balducci L. Do we need geriatric oncology?. Cancer Control. 1994;1(2):91-93.

  • Lyman G, Balducci L. The effect of changing disease risk on clinical reasoning. J Gen Intern Med. 1994;09:488-495.

  • Saba H, Nawab U, Nadeem S, Cosgrove D, Moscinski L, Spiers A, Balducci L, Lyman G, Zuckerman K. 1994;624a.

  • Balducci L, Cox C, Greenberg H, Lyman G, Miguel R, Karl R, Fabri P. Management of cancer in the older aged person. Cancer Control. 1994;1(2):132-137.

  • Balducci L, Barry P. A practical approach to the screening of asymptomatic older persons with cancer. Cancer Control. 1994;1(2):126-131.

  • Balducci L, Lyman G. Cost-effectiveness of hematopoietic growth factors in cancer management. Adv Oncol. 1994;10(1):11-11.

  • Balducci L. Cancer and age: issues and perspectives. Facts Res Gerontol. 1994;173-178.

  • Wyckoff J, Greenberg H, Sanderson R, Wallach P, Balducci L. Breast irradiation in the older woman: a toxicity study. J Am Geriatr Soc. 1994;42:150-152.

  • Balducci L, Lyman G, Schapira D. Trends in prevention and treatment of breast cancer in the older woman. Facts Res Gerontol. 1994;179-192.

  • Beghe C, Balducci L, Cohen H. Secondary prevention of breast cancer in the older woman: issues related to screening. Cancer Control. 1994;1(4):320-326.

  • Balducci L. Perspectives on quality of life of older persons with cancer. Drugs Aging. 1994;4(4):313-324.

  • Balducci L, Greenberg H. Breast cancer in the older woman: therapeutic controversies. Cancer Control. 1994;1(4):350-355.

  • Silliman R, Balducci L, Goodwin J, Holmes F, Leventhal E. Breast cancer care in old age: what we know, don't know, and do. J Natl Cancer Inst. 1993;85(3):190-199.

  • Balducci L, Benson K, Lyman G, Sanderson R, Fields K, Ballester O, Elfenbein G. Cost-effectiveness of leukocyte depletion filters in adult acute myelogenous leukemia. Transfusion. 1993;33(8):665-670.

  • Lyman G, Lyman C, Sanderson R, Balducci L. Decision analysis of hematopoietic growth factor use in patients receiving cancer chemotherapy. J Natl Cancer Inst. 1993;85(6):488-493.

  • Lyman G, Balducci L. Overestimation of test effects in clinical judgment. J Cancer Educ. 1993;8(4):297-308.

  • Ballester O, Moscinski L, Spiers A, Balducci L. Non-Hodgkin's lymphoma in the older person: a review. J Am Geriatr Soc. 1993;41:1245-1254.

  • Virgilio J, Moscinski L, Ballester O, Corrado C, Guida C, Balducci L, Saba H. Acute lymphoblastic leukemia (ALL) in elderly patients. Hematol Oncol. 1993;11(3):121-126.

  • Iacobini M, Torre A, Palumbo G, DelPrincipe D, Digilio G, Balducci L. Study of chronic granulomatous disease by a nitroblue tetrazolium densitometric kinetic test: a new research method. Clin Chim Acta. 1993;221:197-202.

  • Ballester O, Wang T, Saba H, Morelli G, Tantranond O, Balducci L. Classic hemophilia in elderly patients. J Am Geriatr Soc. 1992;40(8):824-826.

  • Shank W, Balducci L. Recombinant hemopoietic growth factors: comparative hemopoietic response in younger vs older aged subjects. J Am Geriatr Soc. 1992;40:151-154.

  • Heal A, Tyson I, Greenberg H, Balducci L, Ketch R, Tenorio L, Berman C, Silbiger M. Evaluation of multiple infusions (IP) of 131-I-HMFG1 MoAb in ovarian and colorectal carcinoma patients and a nude mouse xenograft with and without IV use of unlabeled MoAb. Antibody Immunoconjugates Radiopharm. 1992;5:86-86.

  • Tantranond P, Karam F, Wang T, Parker M, Hescock H, Cherryholmes D, Balducci L. Management of cutaneous squamous cell carcinoma in an elderly man. Report of a case and review of the literature. J Am Geriatr Soc. 1992;40:510-512.

  • Zachariah S, Zachariah B, Wang T, Balducci L. Primary brain tumors in the older patient: an annotated review. J Am Geriatr Soc. 1992;40:1265-1271.

  • Shank W, Balducci L. Hemopoietic growth factors and aging: review. Hematol Rev. 1992;5:229-236.

  • Saba H, Ballester O, Balducci L. Hemopoietic growth factors in myelodysplasia. Hematol Rev. 1992;5:207-221.

  • Ballester O, Moscinski L, Morris D, Balducci L. Acute myelogenous leukemia in the elderly. J Am Geriatr Soc. 1992;40:277-284.

  • Balducci L, Mowrey K. Pharmacology and organ toxicity of cancer chemotherapy in older patients. Oncology. 1992;6:62-68.

  • Balducci L, Cox C, Greenberg H, Lyman G, Miguel R, Karl R, Fabri P. Management of cancer in the older person. In: Balducci L, Lyman G, Erschler W, et al, eds. Comprehensive Geriatric Oncology. 2 ed. London. Harwood Academic Publishers; 1998;363-368.

  • Balducci L, Extermann M. Cancer, carcinogenesis and aging. In: Rosenthal R, Zenilman M, Katlic M, et al, eds. Principles and practice of geriatric surgery. New York, NY: Springer Publishing Co Verlag; 2000;38-45.

  • Extermann M, Balducci L. Practical proposals for clinical protocols in elderly patients with cancer. In: Balducci L, Lyman G, Ershler W, et al, eds. Comprehensive Geriatric Oncology. Amsterdam. Harwood Academic Publishers; 1998;263-269.

  • Balducci L, Cox C, Greenberg H, Lyman G, Miguel R, Karl R, Fabri P. Management of cancer in the older person. In: Complete geriatric oncology. London. Harwood Academic Publishers; 1999;363-368.

  • Balducci L, Extermann M. The cost of cancer prevention and treatment in the older person. In: The older cancer patient. New York, NY: Springer Publishing Company Inc; 2003;284-296.

  • Cova D, Beretta G, Balducci L. Cancer chemotherapy in the older patient. In: Balducci L, Lyman G, Ershler W, et al, eds. Comprehensive geriatric oncology. Amsterdam. Harwood Academic Publishers; 1998;429-442.

  • Balducci L, Lyman G, Erschler W. Management of cancer in the older person. In: Balducci L, Lyman G, Erschler W, et al, eds. Comprehensive Geriatric Oncology. London. Harwood Academic Publishers; 1998;363-368.

  • Balducci L, Extermann M. Cancer and age. In: Haskell C, ed. Cancer treatment. Philadelphia, PA: W.B. Saunders; 2000;435-451.

  • Silliman R, Balducci L. Breast cancer: a geriatric perspective-part II. In: Balducci L, Lyman G, Ershler W, et al, eds. Comprehensive geriatric oncology. Amsterdam. Harwood Academic Publishers; 1998;661-671.

  • Balducci L, Pow-Sang J, Friedland J, Diaz J. Cancer in the elderly part II: prostate cancer. In: Balducci L, ed. Clinics in geriatric medicine. Philadelphia, PA: Saunders; 1997;283-306.

  • Balducci L, Silliman R, Baekey P. Breast cancer: a geriatric perspective-part I. In: Balducci L, Lyman G, Ershler, et al, eds. Comprehensive geriatric oncology. London. Harwood Academic Publishers; 1998;629-660.

  • Balducci L, Extermann M. Issues in the care of the older cancer patient: delayed diagnosis, inadequate treatment, and information gaps. In: The older cancer patient. New York, NY: Springer Publishing Company Inc; 2003;24-44.

The scientific scope of the Senior Adult Oncology Program, under the direction of Dr. Balducci, has been patient assessment and prediction of treatment-related toxicity. This has been the focus of this group's research for several years, and this work has resulted in numerous scientific presentations and publications. The most important scientific findings of the group's research have included the following:

Independence of comorbidity and functional status

  • Ability of comprehensive geriatric assessment to unearth unsuspected conditions that interfere with antineoplastic treatment
  • Prediction of benefits and risk of adjuvant chemotherapy for breast cancer in women aged 70 years and older based on functional status and comorbidity
  • Formulation of the MAX-2 index for prediction of chemotherapy-related toxicity.
  • Assessment of quality of life in older cancer patients.
  • Treatment-related preferences in older patients based on risk-taking profile.
  • Treatment-related preferences in older patients based on national origin.

This main research focus has been interwoven with other research areas, in particular decision analysis, health care delivery, and clinical pharmacology. Ongoing studies include cost-effectiveness of cancer prevention and cancer treatment, enrollment of older individuals in phase II trials, pharmacokinetics of docetaxel in patients aged 70 years and older, and cognitive effects of chemotherapy in older patients.

Dr. Balducci is protocol chairman of the Geriatric Oncology Consortium, which conducts nationwide clinical trials in older individuals, and is chairman of the committee on guidelines for the management of older individuals of the National Comprehensive Cancer Network. He also is involved in cooperative research related to anemia of aging through the National Anemia Action Council.

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