David Shibata, MD

Where You Are:

David Shibata, MD

Surgery

For Consultation Requests or Referrals: (813) 745-6898

 
 

BOARD CERTIFICATION:
          •  Surgery

FELLOWSHIP:
          •  Memorial Sloan-Kettering Cancer Center, New York, NY - Surgical Oncology
          •  Harvard Medical School - Cancer Biology

RESIDENCY:
          •  Beth Israel Deaconess Medical Center, Boston, MA - General Surgery

MEDICAL SCHOOL:
          •  McGill University, Quebec, Canada - Medicine

  • Wang J, Elahi A, Ajidahun A, Clark W, Hernandez J, Achille A, Hao JH, Seto E, Shibata D. The interplay between histone deacetylases and c-Myc in the transcriptional suppression of HPP1 in colon cancer. Cancer Biol Ther. 2014 Sep;15(9):1198-1207. Pubmedid: 24919179.

  • Hernandez JM, Clark W, Weber J, Fulp WJ, Lange L, Shibata D. The impact of pathologic nodal status on survival following neoadjuvant chemoradiation for locally advanced rectal cancer. Int J Colorectal Dis. 2014 Sep;29(9):1061-1068. Pubmedid: 24970021.

  • Koskan AM, Thomas-Purcell KB, Yu D, Quinn GP, Dessureault S, Shibata D, Jacobsen PB, Gwede CK. Discussion of First-Degree Relatives' Colorectal Cancer Risk: Survivors' Perspectives. Health Commun. 2014 Sep;29(8):782-790. Pubmedid: 24229427.

  • Siegel EM, Eschrich S, Winter K, Riggs B, Berglund A, Ajidahun A, Simko J, Moughan J, Ajani J, Magliocco A, Elahi A, Hoffe S, Shibata D. Epigenomic characterization of locally advanced anal cancer: a radiation therapy oncology group 98-11 specimen study. Dis Colon Rectum. 2014 Aug;57(8):941-957. Pubmedid: 25003289. Pmcid: PMC4100249.

  • Kim R, Byer J, Fulp WJ, Mahipal A, Dinwoodie W, Shibata D. Carboplatin and Paclitaxel treatment is effective in advanced anal cancer. Oncology-Basel. 2014 Jul;87(2):125-132. Pubmedid: 25012155.

  • Laronga C, Gray JE, Siegel EM, Lee JH, Fulp WJ, Fletcher M, Schreiber F, Brown R, Levine R, Cartwright T, Abesada-Terk G, Kim G, Alemany C, Faig D, Sharp P, Markham MJ, Shibata D, Malafa M, Jacobsen PB. Florida Initiative for Quality Cancer Care: Improvements in Breast Cancer Quality Indicators During a 3-Year Interval. J Am Coll Surg. 2014 Jul. Pubmedid: 25086813.

  • Kothari N, Schell MJ, Teer JK, Yeatman T, Shibata D, Kim R. Comparison of KRAS mutation analysis of colorectal cancer samples by standard testing and next-generation sequencing. J Clin Pathol. 2014 Jul. Pubmedid: 25004944.

  • Benson AB, Venook AP, Bekaii-Saab T, Chan E, Chen YJ, Cooper HS, Engstrom PF, Enzinger PC, Fenton MJ, Fuchs CS, Grem JL, Hunt S, Kamel A, Leong LA, Lin E, Messersmith W, Mulcahy MF, Murphy JD, Nurkin S, Rohren E, Ryan DP, Saltz L, Sharma S, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Gregory KM, Freedman-Cass DA. Colon cancer, version 3.2014. J Natl Compr Canc Ne. 2014 Jul;12(7):1028-1059. Pubmedid: 24994923.

  • Siegel EM, Jacobsen PB, Lee JH, Malafa M, Fulp W, Fletcher M, Smith JC, Brown R, Levine R, Cartwright T, Abesada-Terte G, Kim G, Alemany C, Faig D, Sharp P, Markham MJ, Shibata D. Florida Initiative for Quality Cancer Care: improvements on colorectal cancer quality of care indicators during a 3-year interval. J Am Coll Surg. 2014 Jan;218(1):16-25.e1. Pubmedid: 24275073.

  • Liu JJ, Druta M, Shibata D, Coppola D, Boler I, Elahi A, Reich RR, Siegel E, Extermann M. Metabolic syndrome and colorectal cancer: Is hyperinsulinemia/insulin receptor-mediated angiogenesis a critical process?. J Geriatr Oncol. 2014 Jan;5(1):40-48. Pubmedid: 24484717.

  • Tofthagen C, Donovan KA, Morgan MA, Shibata D, Yeh Y. Oxaliplatin-induced peripheral neuropathy's effects on health-related quality of life of colorectal cancer survivors. Support Care Cancer. 2013 Dec;21(12):3307-3313. Pubmedid: 23903798.

  • Liu JJ, Druta M, Shibata D, Coppola D, Boler I, Elahi A, Reich RR, Siegel E, Extermann M. Metabolic Syndrome and Colorectal Cancer: Is hyperinsulinemia/Insulin Receptor-Mediated Angiogenesis a Critical Process?. J Geriatr Oncol. 2013 Dec.

  • Gwede CK, Davis SN, Quinn GP, Koskan AM, Ealey J, Abdulla R, Vadaparampil ST, Elliott G, Lopez D, Shibata D, Roetzheim RG, Meade CD. Making it work: health care provider perspectives on strategies to increase colorectal cancer screening in federally qualified health centers. J Cancer Educ. 2013 Dec;28(4):777-783. Pubmedid: 23943277. Pmcid: PMC3864594.

  • Siegel E, Eschrich S, Winter K, Riggs B, Berglund A, Ajidahun A, Simko J, Ajani J, Magliocco A, Elahi A, Coppola D, Shibata D. Epigenomic profiling of anal cancer: does size matter? An RTOG 98-11 specimen study. Sex Health. 2013 Nov;10(6):590. Pubmedid: 24262262.

  • Clark W, Siegel EM, Chen YA, Zhao X, Parsons CM, Hernandez JM, Weber J, Thareja S, Choi J, Shibata D. Quantitative measures of visceral adiposity and body mass index in predicting rectal cancer outcomes after neoadjuvant chemoradiation. J Am Coll Surg. 2013 Jul;216(6):1070-1081. Pubmedid: 23523147.

  • Hernandez JM, Siegel EM, Riggs B, Eschrich S, Elahi A, Qu X, Ajidahun A, Berglund A, Coppola D, Grady WM, Giuliano AR, Shibata D. DNA methylation profiling across the spectrum of HPV-associated anal squamous neoplasia. PLoS One. 2013 May;7(11):e50533. Pubmedid: 23226306. Pmcid: PMC3511539.

  • Benson AB, Bekaii-Saab T, Chan E, Chen YJ, Choti MA, Cooper HS, Engstrom PF, Enzinger PC, Fakih MG, Fenton MJ, Fuchs CS, Grem JL, Hunt S, Kamel A, Leong LA, Lin E, May KS, Mulcahy MF, Murphy K, Rohren E, Ryan DP, Saltz L, Sharma S, Shibata D, Skibber JM, Small W, Sofocleous CT, Venook AP, Willett CG, Gregory KM, Freedman-Cass DA. Localized colon cancer, version 3.2013: featured updates to the NCCN Guidelines. J Natl Compr Canc Ne. 2013 May;11(5):519-528. Pubmedid: 23667203.

  • Benson AB, Bekaii-Saab T, Chan E, Chen YJ, Choti MA, Cooper HS, Engstrom PF, Enzinger PC, Fakih MG, Fenton MJ, Fuchs CS, Grem JL, Hunt S, Kamel A, Leong LA, Lin E, May KS, Mulcahy MF, Murphy K, Rohren E, Ryan DP, Saltz L, Sharma S, Shibata D, Skibber JM, Small W, Sofocleous CT, Venook AP, Willett CG, Gregory KM, Freedman-Cass DA. Metastatic colon cancer, version 3.2013: featured updates to the NCCN Guidelines. J Natl Compr Canc Ne. 2013 Feb;11(2):141-152. Pubmedid: 23411381.

  • Benson AB, Bekaii-Saab T, Chan E, Chen YJ, Choti MA, Cooper HS, Engstrom PF, Enzinger PC, Fakih MG, Fuchs CS, Grem JL, Hunt S, Leong LA, Lin E, Martin MG, May KS, Mulcahy MF, Murphy K, Rohren E, Ryan DP, Saltz L, Sharma S, Shibata D, Skibber JM, Small W, Sofocleous CT, Venook AP, Willett CG, Freedman-Cass DA, Gregory KM. Rectal cancer. J Natl Compr Canc Netw. 2012 Dec;10(12):1528-1564. Pubmedid: 23221790.

  • Cragun D, Malo TL, Pal T, Shibata D, Vadaparampil ST. Colorectal cancer survivors' interest in genetic testing for hereditary cancer: implications for universal tumor screening. Genet Test Mol Biomarkers. 2012 Oct;16(6):493-499. Pubmedid: 22224634. Pmcid: PMC3378022.

  • Siegel EM, Jacobsen PB, Malafa M, Fulp W, Fletcher M, Lee JH, Smith JC, Brown R, Levine R, Cartwright T, Abesada-Terk G, Kim G, Alemany C, Faig D, Sharp P, Markham MJ, Shibata D. Evaluating the quality of colorectal cancer care in the state of Florida: results from the Florida Initiative for Quality Cancer Care. J Oncol Pract. 2012 Jul;8(4):239-245. Pubmedid: 23180990. Pmcid: PMC3396822.

  • Chen DT, Hernandez JM, Shibata D, McCarthy SM, Humphries LA, Clark W, Elahi A, Gruidl M, Coppola D, Yeatman T. Complementary Strand MicroRNAs Mediate Acquisition of Metastatic Potential in Colonic Adenocarcinoma. J Gastrointest Surg. 2012 May;16(5):905-913. Pubmedid: 22362069.

  • Benson AB, Arnoletti JP, Bekaii-Saab T, Chan E, Chen YJ, Choti MA, Cooper HS, Dilawari RA, Engstrom PF, Enzinger PC, Fakih MG, Fleshman JW, Fuchs CS, Grem JL, Leong LA, Lin E, May KS, Mulcahy MF, Murphy K, Rohren E, Ryan DP, Saltz L, Sharma S, Shibata D, Skibber JM, Small W, Sofocleous CT, Venook AP, Willett C, Freedman-Cass DA. Anal Carcinoma, Version 2.2012: featured updates to the NCCN guidelines. J Natl Compr Canc Ne. 2012 Apr;10(4):449-454. Pubmedid: 22491045.

  • Faul LA, Rivers B, Shibata D, Townsend I, Cabrera P, Quinn GP, Jacobsen PB. Survivorship care planning in colorectal cancer: feedback from survivors & providers. J Psychosoc Oncol. 2012;30(2):198-216. Pubmedid: 22416956. Pmcid: PMC3767406.

  • Benson AB, Arnoletti JP, Bekaii-Saab T, Chan E, Chen YJ, Choti MA, Cooper HS, Dilawari RA, Engstrom PF, Enzinger PC, Fleshman JW, Fuchs CS, Grem JL, Knol JA, Leong LA, Lin E, May KS, Mulcahy MF, Murphy K, Rohren E, Ryan DP, Saltz L, Sharma S, Shibata D, Skibber JM, Small W, Sofocleous CT, Venook AP, Willett C. Colon cancer. J Natl Compr Canc Netw. 2011 Nov;9(11):1238-1290. Pubmedid: 22056656.

  • Tanvetyanon T, Corman M, Lee JH, Fulp WJ, Schreiber F, Brown RH, Levine RM, Cartwright TH, Abesada-Terk G, Kim GP, Alemany C, Faig D, Sharp PV, Markham MJ, Bepler G, Siegel E, Shibata D, Malafa M, Jacobsen PB. Quality of care in non-small-cell lung cancer: findings from 11 oncology practices in Florida. J Oncol Pract. 2011 Nov;7(6):e25-e31. Pubmedid: 22379428. Pmcid: PMC3219472.

  • Jacobsen PB, Shibata D, Siegel EM, Lee JH, Fulp WJ, Alemany C, Abesada-Terk G, Brown R, Cartwright T, Faig D, Kim G, Levine R, Markham MJ, Schreiber F, Sharp P, Malafa M. Evaluating the quality of psychosocial care in outpatient medical oncology settings using performance indicators. Psychooncology. 2011 Nov;20(11):1221-1227. Pubmedid: 20878724.

  • Hernandez JM, Farma JM, Coppola D, Hakam A, Fulp WJ, Chen DT, Siegel EM, Yeatman TJ, Shibata D. Expression of the antiapoptotic protein survivin in colon cancer. Clin Colorectal Cancer. 2011 Sep;10(3):188-193. Pubmedid: 21855041.

  • Remily-Wood ER, Liu RZ, Xiang Y, Chen Y, Thomas CE, Rajyaguru N, Kaufman LM, Ochoa JE, Hazlehurst L, Pinilla-Ibarz J, Lancet J, Zhang G, Haura E, Shibata D, Yeatman T, Smalley KS, Dalton WS, Huang E, Scott E, Bloom GC, Eschrich SA, Koomen JM. A database of reaction monitoring mass spectrometry assays for elucidating therapeutic response in cancer. Proteomics Clin Appl. 2011 Aug;5(7-8):383-396. Pubmedid: 21656910. Pmcid: PMC3530891.

  • Gray JE, Laronga C, Siegel EM, Lee JH, Fulp WJ, Fletcher M, Schreiber F, Brown R, Levine R, Cartwright T, Abesada-Terk G, Kim G, Alemany C, Faig D, Sharp P, Markham MJ, Shibata D, Malafa M, Jacobsen PB. Degree of variability in performance on breast cancer quality indicators: findings from the Florida initiative for quality cancer care. J Oncol Pract. 2011 Jul;7(4):247-251. Pubmedid: 22043190. Pmcid: PMC3140448.

  • Hernandez J, Elahi A, Siegel E, Coppola D, Riggs B, Shibata D. HPV L1 capsid protein detection and progression of anal squamous neoplasia. Am J Clin Pathol. 2011 Mar;135(3):436-441. Pubmedid: 21350099.

  • Vadaparampil ST, Quinn G, Malo TL, Alvarez A, Miree CA, Shibata D. Knowledge about hereditary colorectal cancer among colorectal cancer survivors. Genet Test Mol Biomarkers. 2010 Oct;14(5):603-609. Pubmedid: 20722496.

  • Shibata D. Report of the 2010 Japan Traveling Fellow. Bull Am Coll Surg. 2010 Oct;95(10):60-65. Pubmedid: 21449282.

  • Chen Y, Gruidl M, Remily-Wood E, Liu RZ, Eschrich S, Lloyd M, Nasir A, Bui MM, Huang E, Shibata D, Yeatman T, Koomen JM. Quantification of beta-catenin signaling components in colon cancer cell lines, tissue sections, and microdissected tumor cells using reaction monitoring mass spectrometry. J Proteome Res. 2010 Aug;9(8):4215-4227. Pubmedid: 20590165. Pmcid: PMC2924816.

  • Melis M, Hernandez J, Siegel EM, McLoughlin JM, Ly QP, Nair RM, Lewis JM, Jensen EH, Alvarado MD, Coppola D, Eschrich S, Bloom GC, Yeatman TJ, Shibata D. Gene expression profiling of colorectal mucinous adenocarcinomas. Dis Colon Rectum. 2010 Jun;53(6):936-943. Pubmedid: 20485009.

  • Turaga K, Shibata D. K-Ras and MSI: potential markers of both patient prognosis and treatment efficacy. Ann Surg Oncol. 2010 Feb;17(2):354-355. Pubmedid: 19936842. Pmcid: PMC2816800.

  • Faul LA, Shibata D, Townsend I, Jacobsen PB. Improving survivorship care for patients with colorectal cancer. Cancer Control. 2010 Jan;17(1):35-43. Pubmedid: 20010517.

  • Shibata D. Colorectal cancer: perspectives on treatment, survivorship, and outcomes. Cancer Control. 2010 Jan;17(1):4-5. Pubmedid: 20010513.

  • Siegel EM, Ulrich CM, Poole EM, Holmes RS, Jacobsen PB, Shibata D. The effects of obesity and obesity-related conditions on colorectal cancer prognosis. Cancer Control. 2010 Jan;17(1):52-57. Pubmedid: 20010519.

  • Wolkenhauer O, Auffray C, Baltrusch S, Bl?thgen N, Byrne H, Cascante M, Ciliberto A, Dale T, Drasdo D, Fell D, Ferrell JE, Gallahan D, Gatenby R, G?nther U, Harms BD, Herzel H, Junghanss C, Kunz M, van Leeuwen I, Lenormand P, Levi F, Linnebacher M, Lowengrub J, Maini PK, Malik A, Rateitschak K, Sansom O, Sch?fer R, Sch?rrle K, Sers C, Schnell S, Shibata D, Tyson J, Vera J, White M, Zhivotovsky B, Jaster R. Systems biologists seek fuller integration of systems biology approaches in new cancer research programs. Cancer Res. 2010 Jan;70(1):12-13. Pubmedid: 20028868. Pmcid: PMC2802734.

  • Engstrom PF, Arnoletti JP, Benson AB, Berlin JD, Berry JM, Chen YJ, Choti MA, Cooper HS, Dilawari RA, Early DS, Enzinger PC, Fakih MG, Fleshman J, Fuchs C, Grem JL, Knol JA, Leong LA, Lin E, Mulcahy MF, Rohren E, Ryan DP, Saltz L, Shibata D, Skibber JM, Small W, Sofocleous C, Thomas J, Venook AP, Willett C. NCCN clinical practice guidelines in oncology. Anal carcinoma. J Natl Compr Canc Netw. 2010 Jan;8(1):106-120. Pubmedid: 20064293.

  • Jacobsen PB, Shibata D, Siegel EM, Lee JH, Alemany CA, Brown R, Cartwright TH, Levine RM, Smith JC, Abesada-Terk G, Malafa MP. Initial evaluation of quality indicators for psychosocial care of adults with cancer. Cancer Control. 2009 Oct;16(4):328-334. Pubmedid: 19910919.

  • Malafa MP, Corman MM, Shibata D, Siegel EM, Lee JH, Jacobsen PB. The Florida Initiative for Quality Cancer Care: a regional project to measure and improve cancer care. Cancer Control. 2009 Oct;16(4):318-327. Pubmedid: 19910918.

  • Engstrom PF, Arnoletti JP, Benson AB, Chen YJ, Choti MA, Cooper HS, Covey A, Dilawari RA, Early DS, Enzinger PC, Fakih MG, Fleshman J, Fuchs C, Grem JL, Kiel K, Knol JA, Leong LA, Lin E, Mulcahy MF, Rao S, Ryan DP, Saltz L, Shibata D, Skibber JM, Sofocleous C, Thomas J, Venook AP, Willett C. NCCN Clinical Practice Guidelines in Oncology: rectal cancer. J Natl Compr Canc Netw. 2009 Sep;7(8):838-881. Pubmedid: 19755047.

  • Engstrom PF, Arnoletti JP, Benson AB, Chen YJ, Choti MA, Cooper HS, Covey A, Dilawari RA, Early DS, Enzinger PC, Fakih MG, Fleshman J, Fuchs C, Grem JL, Kiel K, Knol JA, Leong LA, Lin E, Mulcahy MF, Rao S, Ryan DP, Saltz L, Shibata D, Skibber JM, Sofocleous C, Thomas J, Venook AP, Willett C. NCCN Clinical Practice Guidelines in Oncology: colon cancer. J Natl Compr Canc Netw. 2009 Sep;7(8):778-831. Pubmedid: 19755046.

  • Melis M, Gruel R, Darwin P, Drachenberg C, Shibata D. Full thickness transanal re-excision following endoscopic removal of malignant rectal polyps. Int J Colorectal Dis. 2009 May;24(5):531-536. Pubmedid: 19159936.

  • Hernandez J, Shibata D. Paraneoplastic hypercalcemia caused by an invasive squamous cell carcinoma arising from a giant anal condyloma acuminatum. Int J Colorectal Dis. 2009 Mar;24(3):359-360. Pubmedid: 18688619.

  • Meredith KL, Hoffe SE, Shibata D. The multidisciplinary management of rectal cancer. Surg Clin N Am. 2009 Feb;89(1):177-215, ix. Pubmedid: 19186236.

  • Nair R, Siegel E, Chen D, Fulp W, Yeatman T, Malafa M, Marcet J, Shibata D. Long-Term Results of Transanal Excision After Neoadjuvant Chemoradiation for T2 and T3 Adenocarcinomas of the Rectum. J Gastrointest Surg. 2008 Oct;12(10):1797-1805. Pubmedid: 18709419.

  • Greenberg J, Shibata D, Herndon JE 2nd, Steele GD J, Mayer R, Bleday R. Local excision of distal rectal cancer: an update of cancer and leukemia group B 8984. Dis Colon Rectum. 2008 Aug;51(8):1185-1191. Pubmedid: 18536973.

  • Elahi A, Zhang L, Yeatman T, Gery S, Sebti S, Shibata D. HPP1-mediated tumor suppression requires activation of STAT1 pathways. Int J Cancer. 2008 Apr;122(7):1567-1572. Pubmedid: 18059030.

  • Engstrom P, Arnoletti J, Benson AB 3rd, Chen Y, Choti M, Cooper H, Dilawari R, Early D, Fakih M, Fuchs C, Grem J, Kiel K, Knol J, Leong L, Ludwig K, Martin EW J, Rao S, Saltz L, Shibata D, Skibber J, Venook A. Colon cancer. J Natl Compr Canc Netw. 2007 Oct;5(9):884-925. Pubmedid: 17977501.

  • Engstrom P, Arnoletti J, Benson AB 3rd, Chen Y, Choti M, Cooper H, Dilawari R, Early D, Fakih M, Fuchs C, Grem J, Kiel K, Knol J, Leong L, Ludwig K, Martin EW J, Rao S, Saltz L, Shibata D, Skibber J, Venook A. Rectal cancer. J Natl Compr Canc Netw. 2007 Oct;5(9):940-981. Pubmedid: 17977503.

  • Saglam O, Garrett CR, Boulware D, Sayegh Z, Shibata D, Malafa M, Yeatman T, Cheng JQ, Sebti S, Coppola D. Activation of the serine/threonine protein kinase AKT during the progression of colorectal neoplasia. Clin Colorectal Cancer. 2007 Sep;6(9):652-656. Pubmedid: 17945038.

  • Kumar N, Shibata D, Helm J, Coppola D, Malafa M. Green tea polyphenols in the prevention of colon cancer. Front Biosci. 2007 Aug;12:2309-2315. Pubmedid: 17127241.

  • Jacobsen PB, Shibata D, Siegel EM, Druta M, Lee JH, Marshburn J, Davenport L, Cruse H, Levine R, Gondi A, Brown R, Malafa M. Measuring quality of care in the treatment of colorectal cancer: the moffitt quality practice initiative. J Oncol Pract. 2007 Mar;3(2):60-65. Pubmedid: 20859375.

  • Strosberg JR, Shibata D, Kvols LK. Intermittent bowel obstruction due to a retained wireless capsule endoscope in a patient with a small bowel carcinoid tumour. Can J Gastroenterol. 2007 Feb;21(2):113-115. Pubmedid: 17299616. Pmcid: PMC2657671.

  • Jensen E, Kvols L, McLoughlin J, Lewis J, Alvarado M, Yeatman T, Malafa M, Shibata D. Biomarkers Predict Outcomes Following Cytoreductive Surgery for Hepatic Metastases from Functional Carcinoid Tumors. Ann Surg Oncol. 2007 Feb;14(2):780-785. Pubmedid: 17146740.

  • Jacobsen P, Shibata D, Siegel E, Mihaela D, Lee J, Marshburn J, Davenport J, Cruse H, Richard L, Gondi A, Brown R, Malafa M. Measuring quality of care in the treatment of colorectal cancer: The Moffitt Quality Pracice Initiative. J Oncol Manag. 2007;3:60-65.

  • Shibata D, Mori Y, Cai K, Zhang L, Yin J, Elahi A, Hamelin R, Wong Y, Lo WK, Chung T, Sato F, Karpeh MS J, Meltzer S. RAB32 hypermethylation and microsatellite instability in gastric and endometrial adenocarcinomas. Int J Cancer. 2006 Aug;119(4):801-6. Pubmedid: 16557577.

  • Sato F, Shimada Y, Selaru F, Shibata D, Maeda M, Watanabe G, Mori Y, StassSA, Imamura M, Meltzer S. Prediction of survival in patients with esophageal carcinoma using artificial neural networks. Cancer. 2005 Apr;103(8):1596-1605. Pubmedid: 15751017.

  • Selaru F, Yin J, Xu Y, Epstein S, Sato F, Mori Y, Olaru A, Deacu E, Wang S, Sterian A, Fulton A, Abraham J, Shibata D, Baquet C, Stass S. An unsupervised approach to identify molecular phenotypic components influencing breast cancer features. Cancer Res. 2004;64(5):1584-1588. Pubmedid: 14996713.

  • Olaru A, Mori Y, Yin J, Wang S, Kimos MC, Perry K, Xu Y, Sato F, Selaru FM, Deacu E, Sterian A, Shibata D, Abraham JM, Meltzer SJ. Loss of heterozygosity and mutational analyses of the ACTRII gene locus in human colorectal tumors. Lab Invest. 2003 Dec;83(12):1867-1871. Pubmedid: 14691305.

  • Wang S, Mori Y, Sato F, Yin J, Xu Y, Zou TT, Olaru A, Kimos M, Perry K, Selaru F, Deacu E, Sun M, Shi Y, Shibata D, Abraham J, Greenwald B, Meltzer S. An LOH and mutational investigation of the ST7 gene locus in human esophageal carcinoma. Oncogene. 2003;22(3):467-470. Pubmedid: 12545169.

  • Mori Y, Selaru F, Sato F, Yin J, Simms L, Xu Y, Olaru A, Deacu E, Wang S, Taylor J, Young J, Leggett B, Jass J, Abraham J, Shibata D, Meltzer S. The impact of microsatellite instability on the molecular phenotype of colorectal tumors. Cancer Res. 2003;63(15):4577-4582. Pubmedid: 12907634.

  • Cunningham SC, Shibata D, Volpe C. Isolated abdominal wound metastasis from a gastrointestinal stromal tumor. Int J Gastrointest Cancer. 2003;33(2-3):129-132. Pubmedid: 14716061.

  • Selaru F, Xu Y, Yin J, Zou T, Liu T, Mori Y, Abraham J, Sato F, Wang S, Twigg C, Olaru A, Shustova V, Leytin A, Hytiroglou P, Shibata D, Harpaz N, Meltzer S. Artificial neural networks distinguish among subtypes of neoplastic colorectal lesions. Gastroenterology. 2002;122(3):606-613. Pubmedid: 11874992.

  • Xu Y, Selaru F, Yin J, Zou T, Shustova V, Mori Y, Sato F, Liu T, OlaruA, Wang S, Kimos M, Perry K, Desai K, Greenwald B, Krasna M, Shibata D, Abraham J, Meltzer S. Artificial neural networks and gene filtering distinguish between global gene expression profiles of Barrett's esophagus and esophageal cancer. Cancer Res. 2002;62(12):3493-3497. Pubmedid: 12067993.

  • Sato F, Harpaz N, Shibata D, Xu Y, Yin J, Mori Y, Zou T, Wang S, Desai K, Leytin A, Selaru F, Abraham J, Meltzer S. Hypermethylation of the p14(ARF) gene in ulcerative colitis-associated colorectal carcinogenesis. Cancer Res. 2002;62(4):1148-1151. Pubmedid: 11861396.

  • Zou T, Selaru F, Xu Y, Shustova V, Yin J, Mori Y, Shibata D, Sato F, WangS, Olaru A, Deacu E, Liu T, Abraham J, Meltzer S. Application of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colon. Oncogene. 2002;21(31):4855-4862. Pubmedid: 12101425.

  • Shibata D, Paty P, Guillem J, Wong W, Cohen A. Surgical management of isolated retroperitoneal recurrences of colorectal carcinoma. Dis Colon Rectum. 2002;45(6):795-801. Pubmedid: 12072633.

  • Mori Y, Sato F, Selaru F, Olaru A, Perry K, Kimos M, Tamura G, MatsubaraN, Wang S, Xu Y, Yin J, Zou T, Leggett B, Young J, Nukiwa T, Stine O, AbrahamJM, Shibata D, Meltzer S. Instabilotyping reveals unique mutational spectra in microsatellite-unstable gastric cancers. Cancer Res. 2002;62(13):3641-3645. Pubmedid: 12097267.

  • Sato F, Shibata D, Harpaz N, Xu Y, Yin J, Mori Y, Wang S, Olaru A, Deacu E, Selaru F, Kimos M, Hytiroglou P, Young J, Leggett B, Gazdar A, Toyooka S, Abraham J, Meltzer S. Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinoma. Cancer Res. 2002;62(23):6820-6822. Pubmedid: 12460892.

  • Shibata D, Sato F, Mori Y, Perry K, Yin J, Wang S, Xu Y, Olaru A, SelaruF, Spring K, Young J, Abraham J, Meltzer S. Hypermethylation of HPP1 is associated with hMLH1 hypermethylation in gastric adenocarcinomas. Cancer Res. 2002;62(20):5637-5640. Pubmedid: 12384516.

  • Tsao JL, Zhang J, Salovaara R, Li ZH, J?rvinen HJ, Mecklin JP, Aaltonen LA, Shibata D. Tracing cell fates in human colorectal tumors from somatic microsatellite mutations: evidence of adenomas with stem cell architecture. Am J Pathol. 1998 Oct;153(4):1189-1200. Pubmedid: 9777950. Pmcid: PMC1853055.

Dr. David Shibata is a Surgical Oncologist and Chief of the Section of Colorectal Oncology in the Gastrointestinal Oncology Department at Moffitt Cancer Center where he has been since 2004.  He is Professor of Surgery and Oncology at the University of South Florida College of Medicine. He is the Associate Program Director of the Surgical Oncology Fellowship and Site Program Director of the USF General Surgery Residency at Moffitt.

Dr. Shibata attended medical school at McGill University in Montreal, Canada and received his General Surgery training at the Beth Israel Deaconess Medical Center in Boston, MA. He completed a Research Fellowship in Cancer Biology at Harvard Medical School and a Surgical Oncology fellowship at Memorial Sloan-Kettering Cancer Center in New York.

Dr. Shibata’s clinical practice is dedicated to the treatment of patients with colorectal cancer. He is particularly interested in laparoscopic/minimally invasive approaches to the treatment of colorectal cancer as well as sphincter-preserving techniques for patients with rectal cancer. He is the medical director of the High Risk/Hereditary Colorectal Cancer and the Colorectal Cancer Survivorship Clinics at Moffitt Cancer Center. Dr. Shibata sits on the panel of the National Comprehensive Cancer Network (NCCN) that establishes national guidelines for the treatment of patients with colorectal cancer.

He is actively involved in colorectal cancer clinical research and clinical trials. Dr. Shibata's laboratory research is funded by the National Cancer Institute and centers on the study of specific molecular mechanisms such as DNA methylation that contribute to the development of colorectal cancer.

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