Bryan McIver, MD, PhD

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Bryan McIver, MD, PhD




          •  Mayo Graduate School of Medicine - Clinical Investigator Fellow in Endocrinology
          •  Mayo Graduate School of Medicine - Endocrinology, Metabolism and Diabetes

          •  Royal Infimary of Edinburgh - Internal Medicine


  • Gallop K, Kerr C, Simmons S, McIver B, Cohen EE. A qualitative evaluation of the validity of published health utilities and generic health utility measures for capturing health-related quality of life (HRQL) impact of differentiated thyroid cancer (DTC) at different treatment phases. Qual Life Res. 2015 Feb;24(2):325-338. Pubmedid: 25106505.

  • McIver B, Castro MR, Morris JC, Bernet V, Smallridge R, Henry M, Kosok L, Reddi H. An independent study of a gene expression classifier (Afirma) in the evaluation of cytologically indeterminate thyroid nodules. J Clin Endocrinol Metab. 2014 Nov;99(11):4069-4077. Pubmedid: 24780044.

  • Donegan D, McIver B, Algeciras-Schimnich A. Clinical consequences of a change in anti-thyroglobulin antibody assays during the follow-up of patients with differentiated thyroid cancer. Endocr Pract. 2014 Oct;20(10):1032-1036. Pubmedid: 24793919.

  • Czerwonka L, Freeman J, McIver B, Randolph GW, Shah JP, Shaha AR, Sherman SI, Tuttle RM, Witterick IJ. Summary of proceedings of the second World Congress on Thyroid Cancer. Head Neck. 2014 Jul;36(7):917-920. Pubmedid: 24677329.

  • Bible KC, Suman VJ, Molina JR, Smallridge RC, Maples WJ, Menefee ME, Rubin J, Karlin N, Sideras K, Morris Iii JC, McIver B, Hay I, Fatourechi V, Burton JK, Webster KP, Bieber C, Traynor AM, Flynn PJ, Cher Goh B, Isham CR, Harris P, Erlichman C. A multicenter phase 2 trial of pazopanib in metastatic and progressive medullary thyroid carcinoma: MC057H. J Clin Endocrinol Metab. 2014 May;99(5):1687-1693. Pubmedid: 24606083. Pmcid: PMC4010705.

  • McIver B. Evaluating thyroid nodules in the information age: new technologies, new opportunities, new challenges. Endocr Pract. 2014 Apr;20(4):370-373. Pubmedid: 24641936.

  • Smallridge RC, Chindris AM, Asmann YW, Casler JD, Serie DJ, Reddi HV, Cradic KW, Rivera M, Grebe SK, Necela B, Eberhardt NL, Carr JM, McIver B, Copland JA, Aubrey Thompson E. RNA sequencing identifies multiple fusion transcripts, differentially expressed genes, and reduced expression of immune function genes in BRAF (V600E) mutant vs BRAF wild-type papillary thyroid carcinoma. J Clin Endocrinol Metab. 2014 Feb;99(2):E338-E347. Pubmedid: 24297791. Pmcid: PMC3913813.

  • McIver B. Evaluation of the thyroid nodule. Oral Oncol. 2013 Jul;49(7):645-653. Pubmedid: 23706806.

  • McIver B. Postoperative surveillance of thyroid carcinoma. Oral Oncol. 2013 Jul;49(7):684-688. Pubmedid: 23706807.

  • Brito JP, Yarur AJ, Prokop LJ, McIver B, Murad MH, Montori VM. Prevalence of thyroid cancer in multinodular goiter versus single nodule: a systematic review and meta-analysis. Thyroid. 2013 Apr;23(4):449-455. Pubmedid: 23067375.

  • Call JA, Caudill JS, McIver B, Foote RL. A role for radiotherapy in the management of advanced medullary thyroid carcinoma: the mayo clinic experience. Rare Tumors. 2013;5(3):e37. Pubmedid: 24179649. Pmcid: PMC3804812.

  • Duick DS, Klopper JP, Diggans JC, Friedman L, Kennedy GC, Lanman RB, McIver B. The impact of benign gene expression classifier test results on the endocrinologist-patient decision to operate on patients with thyroid nodules with indeterminate fine-needle aspiration cytopathology. Thyroid. 2012 Oct;22(10):996-1001. Pubmedid: 22873825. Pmcid: PMC3464064.

  • Reddi HV, Madde P, McDonough SJ, Trujillo MA, Morris JC, Myers RM, Peng KW, Russell SJ, McIver B, Eberhardt NL. Preclinical efficacy of the oncolytic measles virus expressing the sodium iodide symporter in iodine non-avid anaplastic thyroid cancer: a novel therapeutic agent allowing noninvasive imaging and radioiodine therapy. Cancer Gene Ther. 2012 Sep;19(9):659-665. Pubmedid: 22790962.

  • Duick DS, Klopper J, Diggans JC, Friedman L, Kennedy GC, Lanman RB, McIver B. The Impact of Benign Gene Expression Classifier Test Results on the Endocrinologist-Patient Decision to Operate on Patients with Thyroid Nodules with Indeterminate FNA Cytopathology. Thyroid. 2012 Jul. Pubmedid: 22783846.

  • Bible KC, Smallridge RC, Morris JC, Molina JR, Suman VJ, Copland JA, Rubin J, Menefee ME, Sideras K, Maples WJ, McIver B, Fatourechi V, Hay I, Foote RL, Garces YI, Kasperbauer JL, Thompson GB, Grant CS, Richards ML, Sebo T, Lloyd R, Eberhardt NL, Reddi HV, Casler JD, Karlin NJ, Westphal SA, Richardson RL, Buckner JC, Erlichman C. Development of a multidisciplinary, multicampus subspecialty practice in endocrine cancers. J Oncol Pract. 2012 May;8(3 Suppl):e1s-e5s. Pubmedid: 22942830. Pmcid: PMC3348595.

  • Fatourechi MM, Hay ID, McIver B, Sebo TJ, Fatourechi V. Invasive fibrous thyroiditis (Riedel thyroiditis): the Mayo Clinic experience, 1976-2008. Thyroid. 2011 Jul;21(7):765-772. Pubmedid: 21568724.

  • Reddi HV, Madde P, Milosevic D, Hackbarth JS, Algeciras-Schimnich A, McIver B, Grebe SK, Eberhardt NL. The Putative PAX8/PPAR? Fusion Oncoprotein Exhibits Partial Tumor Suppressor Activity through Up-Regulation of Micro-RNA-122 and Dominant-Negative PPAR? Activity. Genes Cancer. 2011 Jan;2(1):46-55. Pubmedid: 21779480. Pmcid: PMC3111009.

  • Foote RL, Molina JR, Kasperbauer JL, Lloyd RV, McIver B, Morris JC, Grant CS, Thompson GB, Richards ML, Hay ID, Smallridge RC, Bible KC. Enhanced survival in locoregionally confined anaplastic thyroid carcinoma: a single-institution experience using aggressive multimodal therapy. Thyroid. 2011 Jan;21(1):25-30. Pubmedid: 21162687.

  • Marlow LA, D'Innocenzi J, Zhang Y, Rohl SD, Cooper SJ, Sebo T, Grant C, McIver B, Kasperbauer JL, Wadsworth JT, Casler JD, Kennedy PW, Highsmith WE, Clark O, Milosevic D, Netzel B, Cradic K, Arora S, Beaudry C, Grebe SK, Silverberg ML, Azorsa DO, Smallridge RC, Copland JA. Detailed molecular fingerprinting of four new anaplastic thyroid carcinoma cell lines and their use for verification of RhoB as a molecular therapeutic target. J Clin Endocrinol Metab. 2010 Dec;95(12):5338-5347. Pubmedid: 20810568. Pmcid: PMC2999968.

  • Bible KC, Suman VJ, Molina JR, Smallridge RC, Maples WJ, Menefee ME, Rubin J, Sideras K, Morris JC, McIver B, Burton JK, Webster KP, Bieber C, Traynor AM, Flynn PJ, Goh BC, Tang H, Ivy SP, Erlichman C. Efficacy of pazopanib in progressive, radioiodine-refractory, metastatic differentiated thyroid cancers: results of a phase 2 consortium study. Lancet Oncol. 2010 Oct;11(10):962-972. Pubmedid: 20851682. Pmcid: PMC3107731.

  • Eberhardt NL, Grebe SK, McIver B, Reddi HV. The role of the PAX8/PPARgamma fusion oncogene in the pathogenesis of follicular thyroid cancer. Mol Cell Endocrinol. 2010 Sep;321(1):50-56. Pubmedid: 19883731. Pmcid: PMC2849860.

  • McIver B, Fatourechi MM, Hay ID, Fatourechi V. Graves' disease after unilateral Riedel's thyroiditis. J Clin Endocrinol Metab. 2010 Jun;95(6):2525-2526. Pubmedid: 20525902.

  • Reddi HV, Madde P, Marlow LA, Copland JA, McIver B, Grebe SK, Eberhardt NL. Expression of the PAX8/PPAR? Fusion Protein Is Associated with Decreased Neovascularization In Vivo: Impact on Tumorigenesis and Disease Prognosis. Genes Cancer. 2010 May;1(5):480-492. Pubmedid: 20827445. Pmcid: PMC2934914.

  • Algeciras-Schimnich A, Milosevic D, McIver B, Flynn H, Reddi HV, Eberhardt NL, Grebe SK. Evaluation of the PAX8/PPARG translocation in follicular thyroid cancer with a 4-color reverse-transcription PCR assay and automated high-resolution fragment analysis. Clin Chem. 2010 Mar;56(3):391-398. Pubmedid: 20056739. Pmcid: PMC3918957.

  • Jovanovic L, Delahunt B, McIver B, Eberhardt NL, Bhattacharya A, Lea R, Grebe SK. Distinct genetic changes characterise multifocality and diverse histological subtypes in papillary thyroid carcinoma. Pathology. 2010;42(6):524-533. Pubmedid: 20854070.

  • Cradic KW, Milosevic D, Rosenberg AM, Erickson LA, McIver B, Grebe SK. Mutant BRAF(T1799A) can be detected in the blood of papillary thyroid carcinoma patients and correlates with disease status. J Clin Endocrinol Metab. 2009 Dec;94(12):5001-5009. Pubmedid: 19850689.

  • Cooper DS, Doherty GM, Haugen BR, Hauger BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, Schlumberger M, Sherman SI, Steward DL, Tuttle RM. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2009 Nov;19(11):1167-1214. Pubmedid: 19860577.

  • Marlow LA, Reynolds LA, Cleland AS, Cooper SJ, Gumz ML, Kurakata S, Fujiwara K, Zhang Y, Sebo T, Grant C, McIver B, Wadsworth JT, Radisky DC, Smallridge RC, Copland JA. Reactivation of suppressed RhoB is a critical step for the inhibition of anaplastic thyroid cancer growth. Cancer Res. 2009 Feb;69(4):1536-1544. Pubmedid: 19208833. Pmcid: PMC2644344.

  • Hay ID, Hutchinson ME, Gonzalez-Losada T, McIver B, Reinalda ME, Grant CS, Thompson GB, Sebo TJ, Goellner JR. Papillary thyroid microcarcinoma: a study of 900 cases observed in a 60-year period. Surgery. 2008 Dec;144(6):980-987. Pubmedid: 19041007.

  • Reddi HV, Madde P, Reichert-Eberhardt AJ, Galanis EC, Copland JA, McIver B, Grebe SK, Eberhardt NL. ONYX-411, a conditionally replicative oncolytic adenovirus, induces cell death in anaplastic thyroid carcinoma cell lines and suppresses the growth of xenograft tumors in nude mice. Cancer Gene Ther. 2008 Nov;15(11):750-757. Pubmedid: 18583996. Pmcid: PMC3180921.

  • Jovanovic L, Delahunt B, McIver B, Eberhardt NL, Grebe SK. Most multifocal papillary thyroid carcinomas acquire genetic and morphotype diversity through subclonal evolution following the intra-glandular spread of the initial neoplastic clone. J Pathol. 2008 Jun;215(2):145-154. Pubmedid: 18393366.

  • Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Sherman SI, Tuttle RM. Management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid. 2006 Feb;16(2):109-142. Pubmedid: 16420177.

  • Sahin M, Allard BL, Yates M, Powell JG, Wang XL, Hay ID, Zhao Y, Goellner JR, Sebo TJ, Grebe SK, Eberhardt NL, McIver B. PPARgamma staining as a surrogate for PAX8/PPARgamma fusion oncogene expression in follicular neoplasms: clinicopathological correlation and histopathological diagnostic value. J Clin Endocrinol Metab. 2005 Jan;90(1):463-468. Pubmedid: 15483076.

  • Gregory Powell J, Wang X, Allard BL, Sahin M, Wang XL, Hay ID, Hiddinga HJ, Deshpande SS, Kroll TG, Grebe SK, Eberhardt NL, McIver B. The PAX8/PPARgamma fusion oncoprotein transforms immortalized human thyrocytes through a mechanism probably involving wild-type PPARgamma inhibition. Oncogene. 2004 Apr;23(20):3634-3641. Pubmedid: 15077183.

  • Fatourechi V, Klee GG, Grebe SK, Bahn RS, Brennan MD, Hay ID, McIver B, Morris JC. Effects of reducing the upper limit of normal TSH values. Jama. 2003 Dec;290(24):3195-3196. Pubmedid: 14693871.

  • Arnold AM, Anderson GW, McIver B, Eberhardt NL. A novel dynamin III isoform is up-regulated in the central nervous system in hypothyroidism. Int J Dev Neurosci. 2003 Aug;21(5):267-275. Pubmedid: 12850060.

  • Foote RL, Brown PD, Garces YI, McIver B, Kasperbauer JL. Is there a role for radiation therapy in the management of H?rthle cell carcinoma?. Int J Radiat Oncol Biol Phys. 2003 Jul;56(4):1067-1072. Pubmedid: 12829143.

  • Jovanovic L, Delahunt B, McIver B, Eberhardt NL, Grebe SK. Thyroid gland clonality revisited: the embryonal patch size of the normal human thyroid gland is very large, suggesting X-chromosome inactivation tumor clonality studies of thyroid tumors have to be interpreted with caution. J Clin Endocrinol Metab. 2003 Jul;88(7):3284-3291. Pubmedid: 12843177.

  • Jovanovic L, Delahunt B, McIver B, Eberhardt NL, Grebe SK. Optimising restriction enzyme cleavage of DNA derived from archival histopathological samples: an improved HUMARA assay. Pathology. 2003 Feb;35(1):70-74. Pubmedid: 12701689.

  • Powell JG, Goellner JR, Nowak LE, McIver B. Rosai-Dorfman disease of the thyroid masquerading as anaplastic carcinoma. Thyroid. 2003 Feb;13(2):217-221. Pubmedid: 12699598.

  • Farrand K, Delahunt B, Wang XL, McIver B, Hay ID, Goellner JR, Eberhardt NL, Grebe SK. High resolution loss of heterozygosity mapping of 17p13 in thyroid cancer: Hurthle cell carcinomas exhibit a small 411-kilobase common region of allelic imbalance, probably containing a novel tumor suppressor gene. J Clin Endocrinol Metab. 2002 Oct;87(10):4715-4721. Pubmedid: 12364463.

  • Hay ID, Thompson GB, Grant CS, Bergstralh EJ, Dvorak CE, Gorman CA, Maurer MS, McIver B, Mullan BP, Oberg AL, Powell CC, van Heerden JA, Goellner JR. Papillary thyroid carcinoma managed at the Mayo Clinic during six decades (1940-1999): temporal trends in initial therapy and long-term outcome in 2444 consecutively treated patients. World J Surg. 2002 Aug;26(8):879-885. Pubmedid: 12016468.

  • Farrand K, Jovanovic L, Delahunt B, McIver B, Hay ID, Eberhardt NL, Grebe SK. Loss of heterozygosity studies revisited: prior quantification of the amplifiable DNA content of archival samples improves efficiency and reliability. J Mol Diagn. 2002 Aug;4(3):150-158. Pubmedid: 12169676. Pmcid: PMC1906979.

  • Velickovic M, Delahunt B, McIver B, Grebe SK. Intragenic PTEN/MMAC1 loss of heterozygosity in conventional (clear-cell) renal cell carcinoma is associated with poor patient prognosis. Mod Pathol. 2002 May;15(5):479-485. Pubmedid: 12011252.

  • Lewis BD, Hay ID, Charboneau JW, McIver B, Reading CC, Goellner JR. Percutaneous ethanol injection for treatment of cervical lymph node metastases in patients with papillary thyroid carcinoma. Ajr Am J Roentgenol. 2002 Mar;178(3):699-704. Pubmedid: 11856701.

  • McIver B, Hay ID, Giuffrida DF, Dvorak CE, Grant CS, Thompson GB, van Heerden JA, Goellner JR. Anaplastic thyroid carcinoma: a 50-year experience at a single institution. Surgery. 2001 Dec;130(6):1028-1034. Pubmedid: 11742333.

  • Brink JS, van Heerden JA, McIver B, Salomao DR, Farley DR, Grant CS, Thompson GB, Zimmerman D, Hay ID. Papillary thyroid cancer with pulmonary metastases in children: long-term prognosis. Surgery. 2000 Dec;128(6):881-886. Pubmedid: 11114619.

  • McIver B, Grebe SK, Wang L, Hay ID, Yokomizo A, Liu W, Goellner JR, Grant CS, Smith DI, Eberhardt NL. FHIT and TSG101 in thyroid tumours: aberrant transcripts reflect rare abnormal RNA processing events of uncertain pathogenetic or clinical significance. Clin Endocrinol (Oxf). 2000 Jun;52(6):749-757. Pubmedid: 10848880.

  • Hay ID, Bergstralh EJ, Grant CS, McIver B, Thompson GB, van Heerden JA, Goellner JR. Impact of primary surgery on outcome in 300 patients with pathologic tumor-node-metastasis stage III papillary thyroid carcinoma treated at one institution from 1940 through 1989. Surgery. 1999 Dec;126(6):1173-1181. Pubmedid: 10598204.

  • Smith JS, Tachibana I, Allen C, Chiappa SA, Lee HK, McIver B, Jenkins RB, Raffel C. Cloning of a human ortholog (RPH3AL) of (RNO)Rph3al from a candidate 17p13.3 medulloblastoma tumor suppressor locus. Genomics. 1999 Jul;59(1):97-101. Pubmedid: 10395805.

  • Spitzweg C, Zhang S, Bergert ER, Castro MR, McIver B, Heufelder AE, Tindall DJ, Young CY, Morris JC. Prostate-specific antigen (PSA) promoter-driven androgen-inducible expression of sodium iodide symporter in prostate cancer cell lines. Cancer Res. 1999 May;59(9):2136-2141. Pubmedid: 10232600.

  • Zhang JS, Nelson M, McIver B, Hay ID, Goellner JR, Grant CS, Eberhardt NL, Smith DI. Differential loss of heterozygosity at 7q31.2 in follicular and papillary thyroid tumors. Oncogene. 1998 Aug;17(6):789-793. Pubmedid: 9715281.

  • Grebe SK, McIver B, Hay ID, Wu PS, Maciel LM, Drabkin HA, Goellner JR, Grant CS, Jenkins RB, Eberhardt NL. Frequent loss of heterozygosity on chromosomes 3p and 17p without VHL or p53 mutations suggests involvement of unidentified tumor suppressor genes in follicular thyroid carcinoma. J Clin Endocrinol Metab. 1997 Nov;82(11):3684-3691. Pubmedid: 9360526.

  • Hart SP, McIver B, Frier BM, Agius RM. Abdominal pain and vomiting in a paint stripper. Postgrad Med J. 1996 Apr;72(846):253-255. Pubmedid: 8733544. Pmcid: PMC2398416.

  • McIver B, Rae P, Beckett G, Wilkinson E, Gold A, Toft A. Lack of effect of thyroxine in patients with Graves' hyperthyroidism who are treated with an antithyroid drug. N Engl J Med. 1996 Jan;334(4):220-224. Pubmedid: 8531998.

  • Hepburn DA, Clark CV, Pell AC, McIver B, Frier BM. Changes in the anterior chamber of the eye during acute hypoglycaemia in humans. Clin Sci (Lond). 1993 Jul;85(1):101-104. Pubmedid: 8149685.

  • Pell JP, McIver B, Stuart P, Malone DN, Alcock J. Comparison of anticoagulant control among patients attending general practice and a hospital anticoagulant clinic. Br J Gen Pract. 1993 Apr;43(369):152-154. Pubmedid: 8323801. Pmcid: PMC1372358.

  • Wieczorek I, Pell AC, McIver B, MacGregor IR, Ludlam CA, Frier BM. Coagulation and fibrinolytic systems in type I diabetes: effects of venous occlusion and insulin-induced hypoglycaemia. Clin Sci (Lond). 1993 Jan;84(1):79-86. Pubmedid: 8382139.

  • McIver B, Connacher A, Whittle I, Baylis P, Thompson C. Adipsic hypothalamic diabetes insipidus after clipping of anterior communicating artery aneurysm. BMJ. 1991 Dec;303(6815):1465-1467. Pubmedid: 1773159. Pmcid: PMC1671669.

  • Kimura JE, McIver B. Potassium channels in mouse spinal cord cells. Adv Exp Med Biol. 1987;221:33-43. Pubmedid: 2449051.

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