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Moffitt’s research departments are typically discipline-based and focus on the career development of our faculty from appointment to tenure. Academic appointments include the ranks of assistant member, associate member and senior member. Due to medical group requirements, M.D.s, whether they perform clinical activities full time or are physician-scientists, are appointed to one of 15 academic clinical departments in the Clinical Science division. Ph.D. faculty members are appointed to one of the research departments within the Basic Science or Population Science divisions. Departments are led by a department chair.


The Molecular Oncology Department faculty members share common interests in understanding signal transduction pathways from the cell surface to the nucleus. They also aim to clarify the mechanisms by which a number of nuclear proteins control different cellular regulatory processes, such as gene expression and DNA replication. The members focus their research in understanding the basic biology of signal transduction and gene regulation and also in identifying and evaluating potential new drugs that target these pathways. READ MORE


The Department of Drug Discovery is interdisciplinary and composed of faculty members with expertise in molecular and cellular biology, structural biology, chemistry and pharmacology. READ MORE


The Department of Immunology faculty members focus on interrogation of immune regulation in cancer with the goal of developing novel immune strategies to combat cancer. READ MORE


The majority of cancer-related mortality is due to metastasis, or the spreading of tumors, a facet of cancer that is difficult to target therapeutically. The Department of Tumor Biology focuses on various aspects of tumor heterogeneity and metastasis, including but not limited to cancer stem cells, tumor microenvironment, epithelial-mesenchymal transition and angiogenesis, as well as invasion and migration of cells. READ MORE


Cancer is a dynamic complex multiscale system that can only truly be understood via the integration of theory and experiments. The mission of the Integrated Mathematical Oncology (IMO) Department is to use such an integrated approach to better understand cancer initiation, progression and treatment and to aid in the clinical utilization of integrated models in precision medicine. The multiscale nature of cancer, in which genetic mutations occurring at a subcellular level manifest themselves as functional changes at the cellular and tissue scale, requires modeling approaches of a similar nature. Within the IMO we have been developing a suite of mathematical and computational models that allow us to consider each of these scales in detail as well as bridge them. Theoretical models are ideal for studying the complex dialogue between the tumor and its environment, and has brought a new foci to Moffitt developing around the themes of tumor evolution and the microenvironment.  READ MORE


The Department of Cancer Imaging and Metabolism (CIM) is focused on the use of non-destructive techniques to monitor cancers and their environments in their native state. The data from such studies are used to inform mathematical models (in collaboration with the Department of Integrated Mathematical Oncology) to develop new paradigms for carcinogenesis and its treatment. READ MORE


The mission of the Department of Cancer Epidemiology is to investigate risk and prevention factors for cancer, biomarkers that identify persons at risk, and lifestyle and molecular factors that affect patient outcomes using human populations as the laboratory. READ MORE


The interdisciplinary faculty in the Department of Health Outcomes and Behavior (HOB) conduct research related to the prevention, detection, and control of cancer through the study of health-related behaviors, health care practices, and health-related quality of life. READ MORE


The Biostatistics and Bioinformatics Department conducts methodological and collaborative research in the areas of biostatistics, computational research in bioinformatics and biomedical data management and integration. Research activities include consultation and quantitative research typically in collaboration with scientists across the basic, population and clinical sciences engaged in the planning, conduct, analysis, and interpretation of research. READ MORE

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