Alphabetical list of MAX2 score

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Alphabetical list of MAX2 score. Primary CSF prophylaxis decreases MAX 2 by 0.06, unless included mandatorily in the regimen design. Doses are in mg/m2 unless specified otherwise.

If the MAX2 of the chemotherapy is <0.20 and the patient had no 1st cycle neutropenia, then the risk of G4 neutropenia in the subsequent cycles is <5%, and the risk of febrile neutropenia <1.5%. Ref: Janssen-Heijnen et al., Crit Rev Oncol Hematol, e-pub Aug 2, 2010. Pubmed ID: 20685130

Regimen MAX2
5FU/LV qw 6/8 (Roswell Park) 0.183
5-FU/LV q4-5w (Mayo)  0.166
5FU/LV qw 6/8 (Roswell Park)+ bevacizumab 0.168
AC 0.223
Bendamustine 120 0.094
Bendamustine90 + rituximab 0.105
CAF 0.291
Capecitabine 2000 0.068
Capecitabine 2500 0.121
Carboplatin/gemcitabine AUC 4-6/1g q3w 0.135
Carboplatin/pemetrexed 0.089
Carboplatin/paclitaxel (5/175) 0.169
Carboplatin/paclitaxel (6/200) 0.172
Carboplatin/docetaxel (5-6/75) 0.249
CHOP 0.341
Cisplatin/docetaxel 75/75 0.251
Cisplatin/etoposide 75-80/100 q3w 0.337
Cisplatin/gemcitabine d1,8,15 q4w 0.285
Cisplatin/gemcitabine d1,8 q3w 0.117
Cisplatin/irinotecan q3w 0.262
Cisplatin/pemetrexed 0.079
Cisplatin/paclitaxel 75/135-24h 0.477
CMF po 0.207
Dacarbazine 0.064
Docetaxel 35 weekly 3/4 weeks  0.04
Doxorubicine 60 0.181
Doxorubicine 75 0.408
ECF 0.149
Fludarabine 0.138
FOLFIRI 0.075
FOLFOX 4 0.119
FOLFOX 6 0.172
modified FOLFOX 6 0.136
Gemcitabine 1g 3/4 weeks 0.077
Gemcitabine 1.25g 3/4 weeks 0.076
Gemcitabine 1g 7/8 then 3/4 weeks 0.11
Gemcitabine FDR 1.5g 3/4 weeks 0.193
Gemcitabine/irinotecan 0.125
Gemcitabine/pemetrexed d8 0.239
Irinotecan q3w 0.226
PEG doxorubicin (Doxil) 50 q4w 0.089
Pemetrexed 0.042
Paclitaxel 175 q3w 0.3
Paclitaxel 200 q3w 0.239
Paclitaxel 80 weekly 0.08
Docetaxel 75 q3w 0.253
Docetaxel 100 q3w 0.398
Docetaxel weekly 0.041
Topotecan IV 0.346
Topotecan oral 0.221
Topotecan weekly 0.124
XELOX 0.134

 

 
 
 
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