Chemical Biology and Molecular Medicine

Where You Are:
Moffitt begins 2013 with two new programs, Cancer Biology & Evolution and Chemical Biology & Molecular Medicine.

Over the last few years, the Molecular Oncology & Drug Discovery (MODD) Program developed an increasing emphasis on research in the areas of tumor evolution, the microenvironment, mathematical modeling and tumor ecology. The Center’s mathematicians have played an important role in leading this new direction. At the same time, breakthroughs in genomics and personalized medicine led to the structural biologists and chemists in the program to increasingly work closely with members of the Experimental Therapeutics program on drug development and on systems level views of pathways and drugs. Due to these evolving interests, the time came to reorganize these two programs around these new themes. Therefore, the MODD Program has evolved into the Cancer Biology & Evolution Program and the Experimental Therapeutics Program has evolved into the Chemical Biology & Molecular Medicine Program.

The initial goal of the Chemical Biology & Molecular Medicine Program (CBMM) is to integrate chemical biology, genomics, and molecular imaging to develop new therapeutic approaches for cancer. Initially, the program aims to:

  1. Identify, validate and characterize molecular targets and actionable deregulated pathways with therapeutic relevance in subsets of human cancer.
  2. Design small molecule chemical probes to modulate such molecular targets and deregulated pathways.
  3. Identify novel biomarker strategies using proteomics, genomics and molecular imaging to guide clinical decision making.
  4. Develop and implement mechanism-based therapeutic clinical trials.

Program Leaders:
Eric B. Haura, MD
Saïd Sebti, PhD

Khaldoun Almhanna, MD, MPH
Melissa Alsina, MD
Soner Altiok, MD, PhD
Rachid Baz, MD
Celeste Bello, MD
Marilyn M. Bui, MD, PhD
Jianfeng Cai, PhD
Barbara A. Centeno, MD
Dung-Tsa Chen, PhD
Alberto A. Chiappori, MD
Prakash Chinnaiyan, MD
Domenico Coppola, MD
William S. Dalton, PhD, MD
Robert J. Deschenes, PhD
Chad A. Dickey, PhD
Steven Allen Eschrich, PhD
Arnold B. Etame, MD, PhD
Hugo F. Fernandez, MD
Mayer Fishman, MD, PhD
Peter A. Forsyth, MD
Susan C. Frost, PhD
Geoffrey T. Gibney, MD
Robert J. Gillies, PhD
Dmitry B. Goldgof, PhD
Jhanelle Gray, MD
Wayne Charles Guida, PhD
Shilpa Gupta, MD
Heather Sook Han, MD
Eric B. Haura, MD
Coy Heldermon, MD, PhD
Pamela Joy Hodul, MD
Roohi Ismail-Khan, MD
Patricia Judson, MD
Jongphil Kim, PhD
Richard Kim, MD
Rami S. Komrokji, MD
John M. Koomen, PhD
Johnathan Mark Lancaster, MD, PhD
Jeffrey E. Lancet, MD
Nicholas James Lawrence, PhD
M. Catherine Lee, MD, FACS
G. Douglas Letson, MD
Ying Li, MD, PhD
Hui-Yi Lin, PhD
Alan F. List, MD
Carl A. Luer, PhD
Richard Lush, PhD
Anthony M. Magliocco, MD
Nupam P. Mahajan, PhD
Amit Mahipal, MD
Mokenge P. Malafa, MD
Roman Manetsch, PhD
Jaime L. Matta, PhD
Grant McFadden, PhD
Mark L. McLaughlin, PhD
Susan Elizabeth Minton, DO
David L. Morse, PhD
Lynn C. Moscinski, MD
Eric K. Outwater, MD
Lia E. Perez, MD
Jose Pimiento, MD
Nikhil Rao, MD
Damon Reed, MD
Uwe Rix, PhD
Lary Allen Robinson, MD
Jeffery Russell, MD, PhD
Solmaz Sahebjam, MD
Michael J. Schell, PhD
Ernst Schonbrunn, PhD
Said M. Sebti, PhD
Kenneth H. Shain, MD, PhD
Lubomir Sokol, MD, PhD
Hatem Soliman, MD
Gregory M. Springett, MD, PhD
Jonathan R. Strosberg, MD
Daniel Sullivan, MD
Haibin Tian, PhD
Javier F. Torres-Roca, MD
Andy M. Trotti, MD
Juan R. Del Valle, PhD
Frank D. Vrionis, MD, MPH, PhD
Catherine J. Walsh, PhD
Robert M. Wenham, MD, MS, FACOG, FACS
Jonathan S. Zager, MD
Ling Zhang, MD
Jingsong Zhang, MD, PhD
Shufeng Zhou, MD, PhD
Kenneth S. Zuckerman, MD
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