Cancer Biology and Evolution

Where You Are:
Moffitt begins 2013 with two new programs, Cancer Biology & Evolution and Chemical Biology & Molecular Medicine.

Over the last few years, the Molecular Oncology & Drug Discovery (MODD) Program developed an increasing emphasis on research in the areas of tumor evolution, the microenvironment, mathematical modeling and tumor ecology. The Center’s mathematicians have played an important role in leading this new direction. At the same time, breakthroughs in genomics and personalized medicine led to the structural biologists and chemists in the program to increasingly work closely with members of the Experimental Therapeutics program on drug development and on systems level views of pathways and drugs. Due to these evolving interests, the time came to reorganize these two programs around these new themes. Therefore, the MODD Program has evolved into the Cancer Biology & Evolution Program and the Experimental Therapeutics Program has evolved into the Chemical Biology & Molecular Medicine Program.

The initial goal of the Cancer Biology & Evolution Program (CBE) is to generate and integrate fundamental knowledge on processes that underlie the evolution of cancer. Initially, the program aims to:

  1. Understand interactions between the intra- and extra-cellular regulatory components of biological systems and how normal interactions are modified to give rise to malignant states.
  2. Identify drivers of tumor evolution and metastasis.
  3. Apply novel approaches to understanding of tumor growth and metastasis through systematic data integration and modeling.

Program Leaders:
Ed Seto, PhD
Robert Gatenby, MD

Mark G. Alexandrow, PhD
Diane S. Allen-Gipson, PhD
Alexander RA Anderson, PhD
Burt Anderson, PhD
Caroline B. Appleyard, PhD
Wenlong Bai, PhD
Srikumar P. Chellappan, PhD
Jiandong Chen, PhD
Jin Q. Cheng, MD, PhD
John L. Cleveland, PhD
W. Douglas Cress, PhD
Gary Daughdrill, PhD
Vrushank G. Dave, MS, PhD
Heiko Enderling, PhD
Jia Fang, PhD
Robert A. Gatenby, MD
Robert J. Gillies, PhD
David Basanta Gutierrez, PhD
Lori A. Hazlehurst, PhD
Younghoon Kee, PhD
Minjung Kim, PhD
Conor Lynch, PhD
Peter G. Medveczky, MD
Eduardo Moros, PhD
Kasia A. Rejniak, PhD
Gary W. Reuther, PhD
Kristina H. Schmidt, MSc, PhD
Ed Seto, PhD
Ariosto S. Silva, PhD
Keiran S. Smalley, PhD
Jianguo Tao, MD, PhD
Jamie Teer, PhD
Jia-Wang Wang, PhD
Sandy D. Westerheide, PhD
Jerry Wu, PhD
Shengyu Yang, PhD
Xiaohong (Mary) Zhang, PhD
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